Colorectal Preneoplastic Lesions Chemoprevention Database
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Documentation on HUGE Table
The Huge table was built by merging five tables: the 4 chemoprevention tables (MAN+TUM+ACF+MIN) and the 2 promotion tables (PROM Acf + PROM Tum), to help agent search. Precise data must be looked for in the original tables. Only the agents with significant preventive effect were gathered from rats studies and included in TUM & ACF tables. And, from most articles testing several agent, only the most potent was kept. In contrast, ALL Human trials and Min mice studies were kept. Last, PROM tables (agents which promote ACF or tumors) are in construction, and contain few agents to date. Thus, the listing of Huge table agents is "biased": e.g., if you rank the Huge table according to potency, you will find mostly Min mice studies at the bottom of table
- Column 1- TUM or ACF or MIN or PromACF or PromTum: Tells the table where the line comes from, and the animal model which was used. A click on this blue cell fetches the full data on this line (one agent, one study, one table). To compare these data with other studies with the same model, you should refer to the original table indicated in this first column: [TUM], [ACF], [Min], [PromACF], [PromTum]TUM is a long-term study in carcinogen-induced rats (or mice), ACF a short-term study in carcinogen-induced rats (or mice) and MIN a study in mutated mice (often, but not always, Min mice).
- Column 2- TREATMENTS:
- - MIN: Treatment & mutation, if it is not Min Apc 850 mutation. Doses are not reported in this [Huge]table, but in [Min] mice table.
- - TUM & ACF: Treatment = agent name & dose, and //carcinogen when it is not AOM or DMH, and /mice when it is not rats.
Doses are reported as percent of the diet (w/w), or ppm (1000 ppm = 0.1%), or mg/kg (body weight). Most studies were done in rats injected with the carcinogens azoxymethane or dimethylhydrazine. When mice were used, or other carcinogens, it is reported in column 1.
- ! - : Caution, potency cannot be accurately estimated when the number of tumor bearing rats in the control group is too small. In studies tagged with a "!", data may be imprecise.
- Column 3- Category of agents. "+" indicates a recent study, not reported in the original publications (Corpet & Tache 2002 N&C, or Corpet & Pierre 2003 CEBP) Classes: 1, polyethylene glycol (PEG); 2, non-steroidal anti-inflammatory drug (NSAID); 3, lipid or oil; 4, phytochemical; 5, fiber or bacteria; 6, calcium or salt; 7, retinoid, vitamin A or D derivative; 8, DFMO or anti-amine; 9, others. Todate, categories of promoting agents (from PROM tables) are not exactly the same as those found in chemoprevention tables
- Column 4- Potency of each agent to reduce the incidence of colon tumors (TUM) or the number of colon aberrant crypt foci (ACF) or the number of polyps in the whole gut of Min mice (both small and large bowel). Potency was estimated by the ratio of value in in control animals divided by value in treated animals. Thus, potency tells the times-fold reduction due to treatment. Promoting agents have potencies smaller than 1 (e.g., 0.5 indicates a two-fold increase in tumor incidence or ACF number). More explanations on potency.
- Column 5- Endpoint: TUM or ACF or MIN +year, or PROM Acf or PROM Tum: Tells the table where the line comes from, and the animal model which was used. See column 1 above.
- Column 6- Reference, Author and year: A click on author's name links to PubMed abstract (click works in the database tables, not here).
Corpet DE & Taché S, 2002, Nutrition & Cancer - & - DE Corpet & F Pierre, 2003, Cancer Epidemiol. Biomarkers Prevention.
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