Line # | in Construction PROMOTER //carcinogen (if not AOM) | Category | Author, year (click name to get abstract) | Potency = time- fold increase in tumor incidence | Percent. Increase incidence | Potency on cancer incidence | Potency on tumor multiplic. | Protocol | Ro- dents | carcinogen N x doxe | weeks | Raw data: treat.& con. incidences | Raw carcin: treat.& con incidences | Raw multiplic. treat.&con. | Line # |
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Q01 | DSS 2% drink for 7 days | dss | Tanaka 03 | 10.00 | 900 | 10.0 | 11.6 | post | Mi' | aom 1x10 | 20 | 8/8 0/5 | 8/8 0/5 | 5.8 0 | Q01 |
Q02 | DSS 2% vs 0.2% drink for 7 days | dss | Suzuki 05 | 10.00 | 900 | 10.0 | 8.0 | post | Mi' | aom 1x10 | 20 | 4/4 0/5 | 4/4 0/5 | 4.0 0 | Q02 |
Q03 | high fat 20%BT vs 5% //DMBA | fat | Mori 01 | 8.00 | 700 | 6.0 | both | Rf' | dmba 10x50 | 60 | 8/20 1/20 | 6/20 1/20 | Q03 | ||
Q04 | low copper 0.2ppm vs 8ppm ! | miner | diSilvestro 92 | 5.00 | 400 | 3.2 | both | Rs' | dmh 12x20 | 25 | ! 5/11 1/11 | .64 .2 | Q04 | ||
Q05 | chlorophyllin 1.5mM drinking water | phyto | Nelson 92 | 4.70 | 2.7 | post | Rf' | dmh 5x20 | 25 | 47 10 | .267 .1 | Q05 | |||
Q06 | NMCOPA NO-Met-Cbx-Prop-NH2 | NOC | Hasegawa 98 | 4.59 | 359 | 1.5 | post | Rf' | nbopa 2x12 | 40 | 3/17 0/13 | 1/17 0/13 | Q06 | ||
Q07 | microflora normal vs germfree | fibact | Reddy Na. 75 | 4.48 | 348 | 11.2 | 10.5 | both | Rf' | dmh 20x20 | 34 | 14/15 5/24 | 14/15 2/24 | 2.1 .2 | Q07 |
Q08 | milk vs beef meat /mice | prot | Nutter 83 | 4.25 | 325 | 6.3 | both | Mb' | dmh 11x20 | 49 | 61/91 15/95 | 1.88 0.3 | Q08 | ||
Q09 | casein 20% vs soy protein | prot | Hakkak 01 | 4.10 | 310 | 3.2 | both | Rs | aom 2x15 | 40 | 21/42 5/41 | 13/42 4/41 | Q09 | ||
Q10 | corn oil 23.5% vs olive oil | fat | Reddy M. 84 | 3.54 | 254 | post | Rf' | aom 2x15 | 34 | % 46 13 | Q10 | ||||
Q11 | caloric excess +30% | other | Kritchevs. 97 | 3.34 | 234 | post | Rf' | dmh 5x30 | 48 | 16/23 5/24 | Q11 | ||||
Q12 | high risk diet vs low risk | combi | Rao Goett. 88 | 3.34 | 234 | 7.0 | both | Rf'' | aom 3x15 | 36 | % 42 12.5 | % 29.2 4.2 | Q12 | ||
Q13 | fasted-refed (4d fast - 1d refed) | other | Caderni 99 | 3.33 | 233 | 4.0 | 3.0 | init | Rf' | aom 1x20 | 10/20 3/20 | 8/20 2/20 | 0.75 0.25 | Q13 | |
Q14 | low fiber 3% cellulose vs 20 | fibact | Madar 96 | 2.76 | 176 | 7.1 | 2.6 | both | Rs' | dmh 5x20 | 24 | 23/25 6/18 | % 40 5.6 | 1.0 .38 | Q14 |
Q15 | corn oil 23.5% vs fish oil | fat | Reddy M. 86 | 2.75 | 175 | 3.8 | 5.2 | post | Rf' | aom 2x15 | 34 | 22/24 8/24 | 15/24 4/24 | 1.96 .38 | Q15 |
Q16 | low fiber 5% cell. vs psyllium 15 | fibact | Wilpart 87 | 2.75 | 175 | 1.5 | both | Rw' | dmh 15x30 | 45 | 11/32 4/32 | 1.5 1.0 | Q16 | ||
Q17 | low vit. B6 1ppm vs 7 ppm | vitB | Komatsu 01 | 2.60 | 160 | 1.3 | both | Mi' | aom 10x5 | 22 | 13/34 5/34 | ! 4/34 3/34 | Q17 | ||
Q18 | IQ 300ppm in diet for 27wk | HAA | Kitamura 06 | 2.36 | 136 | 17 | 8.1 | post | Rf' | dmh 4x40+D | 31 | 11/12 7/18 | 11/12 1/18 | 3.58 0.44 | Q18 |
Q19 | low fiber 0% cellulose vs 25 | fibact | Madar 93 | 2.25 | 125 | 4.4 | both | Rs' | dmh 5x20 | 24 | 18/20 4/10 | 2.2 .5 | Q19 | ||
Q20 | low calcium 0.04% vs 0.32 | miner | Wargovich 90 | 2.13 | 113 | 1.8 | both | Rf'' | aom 8x8 | 32 | % 68 32 | 1.1 .6 | Q20 | ||
Q21 | PhIP+IQ+MeIQ+Glu+P1&2 60ppm | HAA | Hasegawa 94 | 2.00 | 100 | 5.8 | post | Rf' | dmh 4x40+O | 24 | 18/20 9/20 | 5.75 1.00 | Q21 | ||
Q22 | psyllium 20% | fibact | Toth 84 | 2.00 | 100 | both | Ms' | dmh 10x20 | 22-68 | 8/50 4/50 | Q22 | ||||
Q23 | quercetin 3.36% | phyto | Pereira 96 | 1.89 | 89 | 12.0 | 2.6 | both | Rf' | aom 1x30 | 45 | 36/36?19/36 | 24/36 2/36 | 1.67 0.64 | Q23 |
Q24 | PhIP+IQ+MeIQ+Glu+P1&2 12ppm | HAA | Hasegawa 94 | 1.89 | 89 | 3.0 | post | Rf' | dmh 4x40+O | 24 | 17/20 9/20 | 2.95 1.00 | Q24 | ||
Q25 | casein 20% vs whey protein | prot | Hakkak 01 | 1.89 | 89 | 1.5 | both | Rs | aom 2x15 | 40 | 18/32 14/47 | 7/32 7/47 | Q25 | ||
Q26 | oat bran 12% vs wheat bran 12 | fibact | Zoran 97 | 1.89 | 89 | both | Rs' | aom 2x15 | 36 | 17/33 9/33 | Q26 | ||||
Q27 | high fat 18% lard vs 5 //MNG | fat | Sinkeldam 90 | 1.83 | 83 | 1.0 | 2.1 | both | Rw' | mnng 5x6 | 33 | % 73 40 | % 10 10 | 3.0 1.4 | Q27 |
Q28 | low calcium 0.5% vs 2 | miner | Karkare 91 | 1.82 | 82 | 0.3 | 1.8 | post | Rf' | dmh 1x200 | 35 | 21/28 7/17 | 2/28 4/17 | 2.28 1.28 | Q28 |
Q29 | meat protein 21% vs.whey prot. | other | McIntosh 95 | 1.82 | 82 | both | Rs' | dmh 3x15 | 29 | % 53.7 29.5 | Q29 | ||||
Q30 | retinoic a. all trans 10ppm | vitAD | Orita 04 | 1.76 | 76 | 1.2 | 1.1 | post | Rs'' | dmh 5x40+2D | 37 | 15/17 9/18 | 8/17 7/18 | 1.24 1.11 | Q30 |
Q31 | low fiber 5% cell vs wheat bran 15 | fibact | Watanabe 79 | 1.73 | 73 | both | Rf | aom | % 57 33 | Q31 | |||||
Q32 | caloric excess +30% | other | Holt 96 | 1.72 | 72 | 2.2 | both | Rf' | aom 2x15 | 48 | % 88.9 51.8 | 1.81 .81 | Q32 | ||
Q33 | high fat 20% corn oil vs 5% | fat | Holt 96 | 1.72 | 72 | 2.1 | both | Rf' | aom 2x15 | 48 | % 88.9 51.8 | 1.81 .85 | Q33 | ||
Q34 | sedentarity vs voluntary exercise | other | Reddy Su. 88 | 1.61 | 61 | 2.7 | 2.8 | post | Rf' | aom 2x15 | 38 | % 66 41 | % 52 19 | 1.22 .44 | Q34 |
Q35 | meat 60% beef vs 25% | prot | Reddy Na. 76 | 1.60 | 60 | 2.0 | both | Rf' | dmh 20x10 | 30 | 16/28 10/28 | 1.0 .5 | Q35 | ||
Q36 | high fat 20% lipid mix vs 5% | fat | Rao Hirose 01 | 1.59 | 59 | 3.0 | 3.9 | post | Rf' | aom 2x15 | 38 | % 100 63 | % 47.4 15.8 | 5.14 1.31 | Q36 |
Q37 | caloric excess +30% | other | Kumar 90 | 1.58 | 58 | 1.7 | 2.1 | post | Rf' | aom 2x15 | 32 | % 85 52 | % 26 15 | 1.5 0.7 | Q37 |
Q38 | resistant starch vs wheat bran | fibact | Young 96 | 1.57 | 57 | 1.8 | both | Rs | dmh 10x20 | 30 | % 88 56 | 2.0 1.1 | Q38 | ||
Q39 | corn oil 18% vs fish oil 18% | fat | Reddy Su. 88 | 1.47 | 47 | 2.2 | 1.8 | post | Rf' | aom 2x15 | 38 | 25/27 17/27 | 22/27 10/27 | 1.8 1.0 | Q39 |
Q40 | low veget. & fruits 0% vs 20 //MNNG | phyto | Rijnkels 97 | 1.46 | 46 | 3.3 | 2.0 | both | Rw' | mnng 5x6 | 35 | % 73 50 | % 43 13 | 1.37 0.67 | Q40 |
Q41 | safflower oil vs olive oil 5% | fat | Bartoli 00 | 1.43 | 43 | 1.4 | 3.1 | both | Rf' | aom 11x7.4 | 14 | 10/12 7/12 | 10/12 7/12 | 2.5 0.8 | Q41 |
Q42 | sedentarity vs exercise 5h/d | other | Thorling 94 | 1.43 | 43 | 20.0 | 1.6 | post | Rf' | aom 3x15 | 38 | 31/31 21/30 | 10/30 0/30 | 1.8 1.13 | Q42 |
Q43 | low fat 5% vs 24% Crisco ? | fat | Nauss 83 | 1.40 | 40 | 0.9 | both | Rs' | dmh 5x15 po | 60 | 30/39 22/40 | 1.5 1.6 | Q43 | ||
Q44 | low fiber 0% vs pectin 10% | fibact | Heitman 92 | 1.38 | 38 | 1.4 | 1.5 | post | Rs' | dmh 8x12 | 24 | 22/30 16/30 | 22/30 16/30 | .93 .63 | Q44 |
Q45 | low fiber vs wheat bran 24% //MNNG | fibact | Sinkeldam 90 | 1.33 | 33 | 1.0 | 1.9 | both | Rw' | mnng 5x6 | 33 | % 73 55 | % 10 10 | 3.0 1.6 | Q45 |
Q46 | linoleic acid 5% vs stearic 5% | fat | Sakaguchi 84 | 1.32 | 32 | 1.5 | both | Rd' | aom 11x7.4 | 26 | % 100 76 | 2.68 1.79 | Q46 | ||
Q47 | PhIP 0.03% in diet | HAA | Hirose 99 | 1.27 | 27 | 7.0 | post | Rf' | dmh 4x40 | 36 | 20/21 15/20 | 9.1 1.3 | Q47 | ||
Q48 | corn oil 15% vs fish oil 15% | fat | Chang 97 | 1.25 | 25 | 1.3 | both | Rs' | aom 2x15 | 36 | - | 52/74 37/66 | Q48 | ||
Q49 | folate 8mg/kg vs depleted diet | vitB | LeLeu 00 | 1.23 | 23 | 4.3 | 1.8 | both | Rs' | aom 3x15 | 26 | % 79 64 | % 52 12 | 1.68 .96 | Q49 |
Q50 | rutin 0.3% | phyto | Tao 02 | 1.22 | 22 | 1.6 | post | Rf' | aom 3x15 | 36 | 31/35 21/29 | 2.25 1.45 | Q50 | ||
Q51 | antraquinone -1-OH 1.5% //+dss | irrit | Onose 06 | 1.11 | 11 | 1.3 | 5.9 | post | Rf' | dmh 3x40+D | 20 | 10/10 9/10 | 10/10 8/10 | 24.2 4.1 | Q51 |
Q52 | deoxycholic acid 0.3% //+dss | irrit | Onose 06 | 1.11 | 11 | 1.3 | 2.7 | post | Rf' | dmh 3x40+D | 20 | 10/10 9/10 | 10/10 8/10 | 11.0 4.1 | Q52 |
Q53 | Indole-3-carbinol 500ppm | phyto | Suzui 05 | 1.09 | 9 | 1.3 | 2.0 | post | Rf' | aom 2x20 | 35 | 17/18 19/22 | 16/18 15/22 | 2.72 1.36 | Q53 |
Q54 | chlorophyllin 10ppm | phyto | Xu M 01 | 1.04 | 3 | 1.8 | post | Rf' | dmh 5x20 | 51 | 18/20 20/23 | 4.98 2.7 | Q54 | ||
Q55 | nitrite sodium NaNO2 0.2% drink w. | NOC | Kitamura 06 | 1.02 | 2 | 1.02 | 1.8 | both | Rf' | iq 300ppm+D | 31 | 14/15 11/12 | 14/15 11/12 | 6.33 3.58 | Q55 |
Q56 | high calcium 1% vs 0.1% ? | miner | Bull 87 | 1.00 | 1.7 | both | Rs' | aom 8x8 | 26 | % 100 100 | 5.7 3.3 | Q56 | |||
Q57 | neomycin 100ppm | fibact | Reddy 84 | 0.90 | -10 | 2.4 | both | Rf'' | aom 8x8 | 38 | 19/30 21/30 | 17/30 7/30 | Q57 | ||
Q | beef fat 20% vs. 5% | fat | Reddy W. 77 | 3.14 | 214 | 3.8 | 2.1 | post | Rf' | mnu 2x2.5 ir | 34 | 22/30 7/30 | 2.45 1.14 | Q | |
Q | beef fat 20% vs. 5% | fat | Reddy W. 77 | 1.67 | 67 | 2.2 | post | Rf' | mam 1x35 | 34 | 20/30 12/30 | 2.2 1.0 | Q | ||
Q | beef fat 20% vs. 5% | fat | Reddy W. 77 | 2.57 | 157 | 1.2 | post | Rf' | dmh 1x150 | 34 | 18/30 7/30 | 1.33 1.14 | Q | ||
Q | NWD western HF LowCa diet | fat | Newmark 01 | 10.00 | 900 | both | Mc | 0 no init | 78 | 5/12 0/10 | NoBl | ||||
Q | NWD western HF LowCa diet | fat | Yang 08 | 1.96 | 96 | 2.5 | both | Mc | 0 no init | 102 | % 53 27 | 0.67 0.27 | NoBl |
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