Min-mice

Min-mice, last modif.: 27 Jan 2012 - Data ranked by potency - Click column header to sort table or click HERE to select filtering rules - Go BACK to get explanation about column headers.

Line #	Treatment, dose (% or ppm of diet, or mg/kgBW) /mutation (if not Min)	Cate- gory	Author year (click name for abstract)	Potency to reduce polyps	N	sml.int. polyps: Control	sml.int. polyps: Treated	small.int: Treated %Contrl	p	Colon polyps contr.	Colon polyps treatd	Colon: Treated %Contrl	p	Ratio: Sml.int. /Colon	Duration: weeks	Treatment (3-digits) or Additionnal results
M001	sulindac 160ppm	NSAI	Boolbol 96	56.2	1	12	0.0	1.0	*	0.4	0.1	25		0.0	11.5	Sul
M002	EKB-569 +sulindac 150 +37.5ppm	combi	Torrance 00	25.0	1	20	1.0	4.0	*						9	EKB+sul
M003	piroxicam 200ppm	NSAI	Ritland 99	23.3	3	53	2.0	4.0	*						13-26	Pir
M004	piroxicam 0.5mg/mouse/d	NSAI	Hansen-Pet. 02	20.0	1	49	2.0	5.0	*						1	Pir
M005	EKI-785 +sulindac 300 +150ppm	combi	Torrance 00	19.2	1	17	1.0	5.0	*						9	EKI+sul
M006	celecox+CeaVacc./minCea 0.1%	combi+	Zeytin 04	18.2	1	38	2.1	5.5	*						18	celx+vac
M007	piroxicam 200ppm	NSAI	Ritland 99	15.4	3	53	4.0	7.0	*						1.5	Pir
M008	sulindac 320ppm	NSAI+	Hansen-Pet. 00	14.6	1	34	2.3	6.8	*	1.3	0.1	8	*	0.9	7	sul
M009	sulindac 320ppm	NSAI	Chiu McEnt. 97	12.9	1	41	3.0	7.0	*	0.8	0.3	33		0.2	11	Sul
M010	pioglitazone 1600ppm	Ppar+	Niho Takah. 03	11.6	1	71	6.1	8.6	*	1.1	0.1	9	*	0.9	14	pio
M011	CD4+25+ lymphocytes 3x10E5cells	other+	Erdman 05	10.5	1	46	4.4	10	*						3	lym
M012	DFMO + celecoxib 0.5%+500ppm	combi+	Zell Ignat. 06	8.3	1	32	4	12	*						10 /+42	dfmo+cel
M013	EKB-569 150ppm	/EGF	Torrance 00	7.7	1	20	3.0	13	*						9	EKB
M014	celecoxib 0.15% for 3wks	NSAI+	Carothers 06	7.6	1	33	4	13	*						3 /+42	cel No long-term protec
M015	CD4+45RBlo25+ lymphoc. 6x10E5	other+	Rao Pouta. 06	7.3	1	57	7.8	14	*						once	lym
M016	lipitor HMGR +celecox 100+300ppm	combi+	Swamy 04	7.1	1			14	*						12	in high fat diet
M017	atorvastatin + celecoxib 100+300ppm	combi+	Swamy 06	7.1	1	40	6	14	*	1.4	0.1	4		3.9	13 /+42	ato+cel
M018	ursodeox.+sulindac 15-4500+75ppm	combi	Jacoby-Cole 02	6.9	2	18	3.0	15	*							Urs+sul
M019	R-flurbiprofen 10mg/kg/d gav.	other+	Wechter 97	6.8	2	29	4.2	15	*						6	less potent when given b.i.d.
M020	sulindac in diet 200ppm	NSAI+	Yang Fan 03	6.7	1	37	3.4	9	*	0.4	2.1	525	*	0.0	9	Sul
M021	sulindac 160ppm	NSAI	Ritland 99	6.5	1	84	13	16	*						11	Sul
M022	piroxicam 200 or 220ppm	NSAI	Ritland 99	5.6	2	68	12	18	*						11	Pir
M023	sulindac 75-150ppm	NSAI	Jacoby-Cole 02	4.5	2	18	4.0	22	*							Sul
M024	celecoxib 0.12% /F344 M rat apc1137-	NSAI+	Amos-Land. 07	4.5	1	8	1	17	*	3.6	1.2	33	*	0.5	23 /+40	cel rats Pirc male
M025	CD4+25+ lymphocytes 3x10E5cells	other+	Erdman 05	4.3	1	63	15	23	*						3	lym
M026	piroxicam 50ppm	NSAI	Jacoby Cole 00	4.1	1	22	5.0	23	*	1.5	0.6	40		0.6	7	Pir
M027	celecoxib 300ppm	NSAI+	Swamy 06	4.1	1	40	10	24	*	1.4	0.2	14		1.7	13 /+42	cel
M028	tea, white + sulindac 1.5%+80ppm	phyto+	Orner 03	4.0	1	30	6.0	20	*	1.0	1.7	167		0.1	12	tea+sul
M029	indomethacin 10ppm	NSAI+	Niho Mutoh 07	4.0	1	74	18	24		0.9	0.6	67		0.4	14 /+42	ind
M030	p53 rescue CP-313198 200ppm	other+	Rao-Malis. 04	4.0	1			25	*						10	p53
M031	sulindac 150ppm	NSAI	Torrance 00	3.9	1	17	4.0	26	*						9	Sul
M032	catechin(+) 0.1-1%	phyto	Weyant 01	3.8	2	26	7.0	27	*	0.6	0.1	17		1.6	11	Cat
M033	DFMO +piroxicam 1% +50ppm	/N	Jacoby Cole 00	3.7	1	42	11	27	*						9	DFM+pir
M034	piroxicam 50-100-200ppm	NSAI	Jacoby 96	3.7	3	17	4.0	23	*	0.6	0.9	150		0.2	6	Pir
M035	5ASA balzalazide 250mg/kg ?	NSAI	MacGregor 96	3.6	1	22	6.0	28	*			21		1.3	13	ASA
M036	nimesulide /Apc1638Mlh1 400ppm	NSAI+	Yang-Itano 04	3.5	1	4	0.6	16	*	0.2	0.5	250		0.1	26	nim
M037	celecoxib 500-0.15%	NSAI	Jacoby Seib. 00	3.4	2	22	6.0	29	*	1.5	0.6	37		0.8	7	Cel
M038	ursodeox. +sulindac 500 +75ppm	combi	Jacoby-Cole 02	3.4	1	18	5.0	30	*							Urs+sul
M039	R-flurbiprofen 10mg/kg/d gav.	other+	Wechter 97	3.2	2	21	6.6	31	*						6	20mg very potent but toxic
M040	MMP inh. A-177430 200mg/kg/d ip	other+	Wagenaar 03	3.2	1	18	5.6	31	*						6	MMP+COX
M041	DHA /Apc716 3% in female	fat	Oshima 95	3.2	1	219	68	31	*						7	DHA
M042	MMPinh.+COX-2inh.ip 60+40mg/kg/d	combi+	Wagenaar 03	3.1	1	13	4	33	*						6	additive effect
M043	fish oil K85 0.4% in male	fat	Paulsen 97	3.0	1	108	36	33	*	1.0	1.6	160		0.2	17/+1	Fish
M044	celecoxib 500ppm	NSAI+	Zell Ignat. 06	2.6	1	32	11	34	*						10 /+42	cel
M045	celecoxib /minCea.Tg 0.1%	NSAI+	Zeytin 04	2.9	1	38	13	35	*						18	celx
M046	curcumin 0.1%	phyto	Mahmoud 00	2.8	1	33	12	36	*						11	Cur
M047	caffeic acid CAPE 0.15%	phyto	Mahmoud 00	2.7	1	33	12	37	*						11	CAP
M048	folate /MinMsh2-- 8ppm	vitB	Song Sohn 00	2.7	1	299	111	37	*	1.7	0.6	35		1.0	8 /+3	Fol
M049	piroxicam 50ppm	NSAI	Jacoby Cole 00	2.6	1	23	8	35	*	0.8	1.4	169		0.2	3.5/7	Pir
M050	arginine 0.2% drinking water	/N+	Zell Ignat. 06	2.5						0.6	0.2	39	*	2.5	10 /+42	arg
M051	R-flurbiprofen 10mg/kg/2d gav.	other	Wechter 00	2.5	1	25	10	40	*						6	25w survival cont27% treat100
M052	sulindac in water 180ppm	NSAI+	Yang Fan 03	2.5	1	37	11	30	*	0.4	3.8	950	*	0.0	9	Sul
M053	COX-2 inh.A-285969 40-80mg/kg/d ip	NSAI+	Wagenaar 03	2.5	2	16	6	40	*						6	MMP
M054	NO-aspirin (NA-ASA) 100mg/kg/d i.r.	/N+	Williams 04	2.4	1	25	10	41	*						3	NO-asp
M055	NO-1886 LPL inducer 800ppm	other+	Niho Mutoh 05	2.4	1	121	50	42	*	1.0	0.3	30	*	1.4	13	NO1
M056	wheat/bran, Madison 45-50%	fibact+	Drankhan 03	2.4	2	24	10	42	*	0.6	0.2	38		1.1	10	high orthophenolic wheat
M057	MF-tricyclic /Apc716 3.5-14mg/kg/d	NSAI	Oshima 96	2.3	2	424	187	44	*	1.8	0.3	19	*	2.3	8	MF-tri
M058	tea extr.+sulindac 0.1%water+300ppm	combi	Suganuma 01	2.3	1	72	32	44	*						10	Tea+sul
M059	sulforaph.300ppm+dibenzoylmeth.0.5%	combi+	Shen Khor 07	2.3	1	52	22	43	*	0.8	0.0	5	*	9.0	10 /+35	sul+dib
M060	R-flurbiprofen 5mg/kg/d gav.	other+	Wechter 97	2.3	2	26	12	44	*						6	R-flur
M061	guanidinoethyldisulfide 10-30mg/kg/d	/N+	Mabley 04	2.2	2	47	21	45	*	2.3	1.3	57	*	0.8	8	gua
M062	CD4+25+ lymphocytes 3x10E5cells	other+	Erdman 05	2.2	1	63	29	45	*						0.4	lym
M063	cellulose 5-10% vs.0 in 20%fat	fibact	Yu Whiteley 01	2.2	2	30	14	45	*	0.4	0.4	107		0.4	9	Cel
M064	copper 6vs1ppm	other	Davis 00	2.2	1	47	22	46	*	1.0	0.3	27		1.7	13	Cop
M065	DFMO 2%	/N	Erdman 99	2.2	1	45	21	46	*	3.5	3.2	92		0.5	9	DFM
M066	MF-tricycl./MinMsh2ñ 13mg/kg/d	NSAI	Lal Ash 01	2.2	2	200	92	46	*	9.0	5.7	63	*	0.7	2.5	MF-tri
M067	pioglitazone 200-400ppm	Ppar+	Niho Takah. 03	2.2	2	71	33	46	*	1.1	0.6	50		0.9	14	pio
M068	5ASA balzalazide 62-125mg/kg ?	NSAI	MacGregor 96	2.1	2	22	11	49	*						13	ASA
M069	aspirin 250-500ppm	NSAI	Barnes 98	2.1	2	36	17	48	*	1.0	0.7	65		0.7	7	Asp
M070	sulindac 0.6mg/mouse/d	NSAI	Hansen-Pet. 02	2.1	1	46	22	48	*						1	Sul
M071	NO-1886 LPL inducer 400ppm	other+	Niho Mutoh 05	2.1	1	121	58	48	*	1.0	0.4	40	*	1.2	13	NO1
M072	caloric restriction -40%	other+	Mai Colbert 03	2.0	1	9	4	43	*	0.6	0.8	133		0.3	9	CR
M073	dibenzoylmethane DBM 1% (licorice)	phyto+	Shen Khor 07	2.0	1	52	26	50	*	0.8	0.3	40		1.3	10 /+35	dib
M074	tea, green or white 1.5%	phyto+	Orner 03	2.0	2	30	15	50	*	1.0	0.5	51		1.0	12	tea
M075	bran rice 30%	fibact+	Verschoyle 07	2.0	1	37	19	50	*	2.5	1.7	68	*	0.7	14 /+28	bran
M076	meat beef low-fat 27% /female	other+	Kettunen 03	1.9	1	56	29	51	*						10	Beef
M077	cyanidin-3-glucoside 0.3%	phyto+	Cooke 06	1.9	1	53	27	52	*						12 /+28	C3G
M078	sulforaphane 600ppm	phyto+	Shen Khor 07	1.9	1	52	27	52	*	0.8	0.2	19	*	2.7	10 /+35	sul
M079	piroxicam /Apc1309 500ppm	NSAI	Quesada 98	1.9	1	31	16	52	*	2.6	1.5	56	*	0.9	10	Pir
M080	wheat bran 5-10% vs0, in 20%fat	fibact	Yu Whiteley 01	1.9	2	30	16	53	*	0.4	0.6	143	*	0.4	9	Whe
M081	EPA eicopentaenoid a. 3.1%	fat+	Hansen-Pet. 00	1.9	1	34	18	52	*	1.3	0.9	69		0.8	7	EPA
M082	sulindac 84ppm drink.water	NSAI+	VanKranen 03	1.9	2	61	31	50		2.4	3.2	131		0.4	10	sul
M083	PEG 3350 10% in water	PEG+	Roy Gulizia 02	1.9	1	39	20	51	*	3.2	2.6	81		0.6	10	PEG
M084	sulforaphane 6mcmol/d	phyto+	Myzak 06	1.8	1	46	24	53	*						10 /+42	sulf
M085	ZD6474 VEGFrec.tyr.kin. 50mg/kg/d	/EGF	Wilkinson 04	1.9	1	91	50	54	*	3.5	0.8	24	*	2.3	4	77% in polyp burden
M086	SDA stearidonic acid 3.1%	fat+	Hansen-Pet. 00	1.9	1	34	19	55	*	1.3	0.2	15	*	3.6	7	SDA
M087	tyrosine kinase prodrug DMU-135 0.2%	other+	Sale Tunst. 06	1.9	1	60	32	53	*	1.6	1.2	73		0.7	14 /+28	DMU
M088	sulindac 200ppm in water	NSAI+	Kang 03	1.9	1	58	28	48		3.7	5.3	143		0.3	10	sign.reduct. /cecal polyps
M089	VEGF inhib. AZD2171 5mg/kg/d early	other+	Goodlad 06	1.8	1	91	50	55	*	3.5	1.4	40	*	1.4	4 /+42	vegf early treated
M090	carnosol 0.1%	phyto+	Moran 05	1.8	1	33	18	55	*	0.1	0.2	200		0.3	10	car
M091	CEA vaccine /minCea.Tg boost/mo.	other+	Zeytin 04	1.8	1	38	21	55	*						18	vac
M092	epigallocatechin gallate(-) .32%water	phyto	Ju-Bose 04	1.8	1	30	17	55	*						6	EGCG
M093	sulindac 80ppm	NSAI+	Orner 03	1.8	1	30	16	53	*	1.0	1.1	111		0.5	12	sul
M094	sulindac 160ppm	NSAI+	Emami 04	1.8	1	67	38	56	*	1.8	0.4	22	*	2.5	9	sul
M095	celecoxib 0.15%	NSAI	Jacoby Seib. 00	1.8	1	23	11	48	*	0.8	2.0	253		0.2	3.5/7	Celx
M096	DFMO 1%	/N	Jacoby Cole 00	1.8	1	42	24	57	*						9	DFM
M097	EKI-785 300ppm	/EGF	Torrance 00	1.8	1	17	10	56	*						9	EKI
M098	fish oil K85 0.4-1.2-2.5% female	fat	Paulsen 97	1.8	3	73	40	55	*	0.8	0.3	38		1.5	17/+1	Fish
M099	rofecoxib /Apc716 25-75ppm	NSAI	Oshima 01	1.8	2	201	111	55	*						8	Rof
M100	selenium p-XSC 10-20ppm	other	Rao Cooma 00	1.8	2	41	24	58	*	2.8	1.2	43	*	1.3	11	Sel
M101	sphingomyelin &cer. 0.1%	other	Schmelz 01	1.8	3	56	31	56	*	1.4	0.7	50	*	1.1	8	Sph
M102	sulindac 160ppm	NSAI	Huerta 02	1.8	1	17	9	51	*	4.5	3.0	67		0.8	10	Sul
M103	uroguanylin 26 mcrg/mouse/d	other	Shailubhai 00	1.8	2	48	27	57	*	0.7	0.1	14	*	4.0	11	Uro
M104	aspirin 500mcg/d	NSAI+	Mahmoud 98	1.8	1	32	18	56	*	0.6	0.5	83		0.7	10	Asp
M105	chafuroside (from ool. tea) 10ppm	phyto+	Niho Mutoh 06	1.8	1	144	81	56	*	0.8	0.8	96		0.6	14	cha
M106	celecoxib 0.12% /F344 F rats apc1137-	NSAI+	Amos-Land. 07	1.7	1	1	1	133		1.3	0.3	23	*	5.8	23 /+40	cel rats Pirc female
M107	Vaccinium myrtillus &vitis frz-dry 10%	phyto+	Paivarinta 04	1.7	2	65	38	58	*						10	ad.size blueb.x1.1 ling.x0.7
M108	ICG-001 B-catenin inhib. 257mg/kg/d	other+	Emami 04	1.7	1	67	39	58	*	1.8	1.1	61		1.0	9	ICG
M109	epigallocatechin-3-gallate 0.16-0.32%	phyto+	Ju Hong 05	1.7	4	29	17	58	*	1.0	0.9	90		0.6	11-14	EGCG
M110	DFMO 0.5% drinking water	/N+	Yerushalmi 06	1.7	1	41	24	58	*	0.5	0.7	136		0.4	10 /+42	dfmo
M111	guar gum 5-10% vs0 in 20%fat	fibact	Yu Whiteley 01	1.7	2	30	18	59	*	0.4	0.4	93		0.6	9	Guar
M112	mofezolac cox1 /Apc1309 0.12%	NSAI+	Kitamura 02	1.7	1	47	28	59	*	1.5	1.0	67		0.9	8	large polyps more reduced
M113	estradiol /ovariectomized 21æg/d	other+	Javid 05	1.7	1	35	21	61	*	0.8	0.4	50		1.2	13	E2
M114	coumestrol /ovariectomiz. 100ppm	other+	Javid 05	1.6	1	35	21	61	*	0.8	0.2	25	*	2.5	10	cou
M115	curcumin postweaning 0.002	phyto+	Perkins 03	1.6	1	115	70	61	*						13	Cur
M116	bran oil (wheat )	phyto+	Sang Ju 06	1.6	1	28	18	62	*	0.4	0.3	63		1.0	8 /+42	wbo duplicate st.less signif.
M117	BB protease inhibitor 0.1-0.5%	phyto	Kennedy 96	1.6	2	11	7	63	*	0.6	0.4	67	*	0.9	13 /d-2	BBPI
M118	piroxicam 200ppm	NSAI	Ritland 99	1.6	2	53	34	64							2-4d	Pir
M119	sc26196 /desaturase 100mg/kg/d	other	Hansen-Pet. 02	1.6	1	54	34	63	*						7	sc2
M120	soybean oil low- 5% vs.20, no fibr diet	fat	Yu Whiteley 01	1.6	1	30	19	62	*	0.4	0.2	57		1.1	9	soyoil
M121	sulindac /Apc716 150ppm	NSAI	Oshima 01	1.6	1	201	125	62	*			100		0.6	8	Sul
M122	wheat bran:fat 20:5 vs.3:20% /Apc716	fibact	Hioki 97	1.6	1	211	135	64	*	2.0	0.7	36	*	1.8	7	Whe
M123	glucosylceramide from soy 0.1%	fat+	Symolon 02	1.6	1	43	27	63	*	1.2	0.8	67		0.9	8	half-effect at 0.025%
M124	pioglitazone 100ppm	Ppar+	Niho Takah. 03	1.6	1	71	45	63		1.1	1.0	91		0.7	14	pio
M125	Mirtoselect (from bilberry) 0.3%	phyto+	Cooke 06	1.6	1	62	40	64	*						12 /+28	Mir
M126	aspirin prew.+curc.postw 500ppm+0.2%	combi+	Perkins 03	1.5	1	132	86	65	*						13/-3	not better than each
M127	ellagic acid 0.16%	phyto+	Paivarinta 06	1.5	1	71	47	65							10 /+35	ell cloudberry no effect either
M128	meat beef 27% low-fat dried	other+	Kettunen 03	1.5	4	59	38	66							10	sign.reduct.in females 10 w
M129	atorvastatin 100ppm HMGR inhib.	other+	Swamy 06	1.5	1	40	27	67	*	1.4	0.6	43		1.6	13 /+42	ato
M130	aminoguanidine 0.15% in water	/N	Ahn Ohshima 01	1.5	1	73	50	69		0.8	0.5	63		1.1	10	Ami
M131	arginine deficient diet No arginine diet	/N	Ahn Ohshima 01	1.5	1	102	68	67	*	0.2	0.6	300		0.2	10	Arg
M132	JTE-523 100ppm	NSAI	Sasai 00	1.5	1	123	84	68	*						8	JTE
M133	PgEP4 antagonist 300ppm	NSAI	Mutoh 02	1.5	1	61	42	69	*	0.5	0.2	40		1.7	7	ONO
M134	piroxicam 25-50-100ppm	NSAI	Jacoby Cole 00	1.5	3	42	28	66	*						9	Pir
M135	sulindac 300ppm	NSAI	Suganuma 01	1.5	1	72	49	68							10	Sul
M136	pioglitazone /Apc1309 100-200ppm	Ppar+	Niho Takah. 03	1.5	2	36	24	67	*	0.6	0.5	75		0.9	6	pio
M137	iNOS inhib. ono1714 50ppm /Min+dss	/N+	Kohno 07	1.5	1	53	37	71		4.6	1.4	31	*	2.3	5 /+42	NOS /DSS
M138	troglitazone /Apc1638Mlh1 0.2%	Ppar+	Yang Fan 05	1.5	1	4	1	35		0.2	1.3	813	*	0.0	26	tro
M139	olive oil + fruits & veg. 11%+10%	other+	Mai Colbert 03	1.5	1	9	6	67	*	0.6	0.5	83		0.8	9	mediterranean
M140	inulin 10%	fibact+	Kettunen 03	1.5	2	58	40	68							10	larger adenoma inulin grp
M141	tricin (from rice bran) 0.2%	phyto+	Cai AlFay. 05	1.5	1	21	14	67	*	0.3	0.6	200		0.3	14	Tri
M142	nimesulide cox2 /Apc1309 400ppm	NSAI+	Kitamura 02	1.5	1	47	32	68	*	1.5	1.2	80		0.9	8	larger polyps more reduced
M143	flaxseed mix (59%fat) 15%	phyto+	Oikarinen 05	1.5	1	54	37	69	*	0.3	0.4	127		0.5	10	fla
M144	FP15 (rid peroxynitrite) 1-3mg/kg/d	/N+	Mabley 04	1.4	2	47	33	70	*	2.3	1.3	57	*	1.2	8	FP15
M145	DHA docohexanenoic 3.1%	fat+	Hansen-Pet. 00	1.4	1	34	23	69		1.3	1.6	123		0.6	7	DHA
M146	exercise (treadmill) 1.1km/1h/d males	other+	Mehl 05	1.4	1	93	66	71	*						9	Exer
M147	aspirin 400ppm	NSAI	Sansom 01	1.4	1	34	25	74							53 /-3	Asp
M148	celecoxib 150-500ppm	NSAI	Jacoby Seib. 00	1.4	3	23	17	73	*	1.1	0.7	65		1.1	3.5/-7	Celx
M149	fish oil K85 1.25-2.5% in male	fat	Paulsen 97	1.4	2	108	80	74		1.0	0.7	65		1.1	17/+1	Fish
M150	lignan HMR 200ppm /inulin diet	phyto	Oikarinen 00	1.4	1	40	27	67	*	1.3	1.7	131		0.5	5.5	Lign
M151	selenium in broccoli 2.1ppm Se	other	Davis 02	1.4	1	67	48	71	*	1.9	0.4	22	*	3.2	10	Sel
M152	ursodeoxycholic acid 500-0.15%	other	Jacoby-Cole 02	1.4	2	18	13	73	*							Urs
M153	mofezolac cox1 /Apc1309 600ppm	NSAI+	Kitamura 04	1.4	1	58	42	72							4	polyp area 17% reduction
M154	wheat/bran, 3 cultivars 45-50%	fibact+	Drankhan 03	1.4	5	24	17	73		0.6	0.4	65		1.1	10	medium orthophenolic wheat
M155	resveratrol 0.2%	phyto+	Sale Tunst. 05	1.4	1	106	80	75	*	9.0	4.2	47	*	1.6	12	resv 0.05% no effect
M156	exercise (volunt.wheel run.) 3.8km/d	other+	Colbert 06	1.4	1	20	15	77	*	2.1	0.8	36	*	2.1	10 /+42	exer negative energy balance
M157	DFMO 0.5%	/N+	Zell Ignat. 06	1.4	1	32	24	73							10 /+42	dfmo
M158	cherries 20% freeze-dried	phyto+	Kang Seera. 03	1.4	1	58	42	72		3.7	3.3	89		0.8	10	sign.reduct. /cecal polyps
M159	resveratrol analog. DMU-212 0.2%	phyto+	Sale Tunst. 05	1.3	1	106	82	78	*	9.0	4.6	51	*	1.5	12	DMU 0.05% no effect
M160	PgEP1+4 ant. /Apc1309 400+400ppm	NSAI+	Kitamura 03	1.3	1	38	29	76							6	polyp area 56% reduction
M161	chenodeoxycholic ac. 0.5%	other	Mahmoud 99	1.3	1	33	25	77	*	0.4	0.6	150		0.5	10	Che
M162	folate 8-20ppm	vitB	Song Medline 00	1.3	2	24	19	80		4.6	3.7	80		1.0	13 /+3	Fol
M163	rye bran 10%	fibact	Mutanen 00	1.3	1	35	26	75	*	1.8	1.4	78		1.0	5.5	Rye
M164	sulindac /MinMsh2ñ 13mg/kg/d	NSAI	Lal Ash 01	1.3	1	44	33	74		4.8	5.0	104		0.7	22	Sul
M165	tea green- extract 0.1% in water	phyto	Suganuma 01	1.3	1	72	56	78							10	Tea
M166	sulindac sulfone 50mg/kg/d gav.	other	Wechter 00	1.3	1	25	20	77							6	no effect on tumor area
M167	SNAIL AS-PMO 10mcg/gBW ip 5d/7	other+	Roy Iversen 04	1.3	1	26	20	78	*						6	sna
M168	flaxseed +rapeseed oil 9%	fat+	Oikarinen 05	1.3	1	54	42	78		0.3	0.4	127		0.6	10	fla
M169	resveratrol 90mg/kg	phyto+	Ziegler 04	1.3	1	33	26	79							7	resv
M170	aspirin preweaning 500ppm	NSAI+	Perkins 03	1.3	1	132	104	79	*						3/-3	Asp
M171	green tea 0.6% drink /Min+AOM	phyto+	Issa Volate 07	1.2	1	39	32	82		1.8	0.9	50	*	1.6	8 /+56	tea no regression
M172	bezafibrate /Apc1309 100-200ppm	Ppar+	Niho Takah. 03	1.2	2	37	30	81	*	0.7	0.5	71		1.1	6	100ppm N.S. effect
M173	PgEP1 ant. /Apc1309 400ppm	NSAI+	Kitamura 03	1.2	1	38	32	82							6	polyp area 12% reduction
M174	germ-free status germ-free	other	Dove Clipson 97	1.2	1	32	28	88		1.4	0.9	66		1.3	12	Germ
M175	IQ /Apc716 300ppm	HAA	Oshima 96	1.2	1	254	213	84							11	IQ
M176	lactoferrin bovine 0.2% or 2%	other	Ushida 98	1.2	1	54	44	82		1.2	1.0	83		1.0	8	Bov
M177	MeIQx /Apc716 400ppm	HAA	Oshima 96	1.2	1	254	221	87							11	MeIQx
M178	rutin-quercetin 2%	phyto	Mahmoud 00	1.2	2	33	28	85							11	Rut
M179	sulindac /Apc716 12mg/kg/d	NSAI	Oshima 96	1.2	1	424	356	84		1.8	0.9	50		1.7	8	Sul
M180	sulindac /MinMsh2-- 13mg/kg/d	NSAI	Lal Ash 01	1.2	1	354	294	83	*	13.0	14.0	108		0.8	4	Sul
M181	VEGF-A inhib. Mab G6-31	other+	Korsisaari 07	1.2	1	120	100	83							6 /+91	vegf tumor burden 7-fold reduction
M182	PJ34 PARP inhibitor 3-10mg/kg/d	/N+	Mabley 04	1.2	2	47	40	85	*	2.3	1.4	61	*	1.4	8	low dose NS
M183	mushroom extr. Lsy16 400mg/kgBW	phyto+	Merkel 06	1.2	1	17	15	86							6.5	mush
M184	EGF epid.growth factor 223mcrg/Kg/d	other+	Bashir 03	1.2	1	75	65	87		2.9	2.6	90		1.0	4	EGF +40% burden in duoden.
M185	indomethacin /Apc1309 10ppm	NSAI+	Kitamura 04	1.1	1	58	51	88							4	polyp area 46% reduction
M186	flaxseed 0.5%	phyto+	Oikarinen 05	1.1	2	57	51	89		1.0	0.6	63		1.4	7	fla
M187	exercise (treadmill) 0.9km/45min/d	other+	Colbert 03	1.1	2	8	7	88		0.4	0.6	150		0.6	5.5	Exer
M188	acarbose /Apc1309 400ppm	phyto	Quesada 98	1.1	1	31	29	93		2.6	2.2	84		1.1	10	Aca
M189	curcumin 0.2%	phyto	Collett 01	1.1	1	14	13	94							10	Curc
M190	exercise 1.2 km/1h/d	other	Colbert 00	1.1	1	37	33	89		3.2	2.4	75		1.2	7	Exer
M191	food restriction 20% restriction	other	Kakuni 02	1.1	1	55	51	93		2.3	1.1	48		2.0	7	FR
M192	fructo-oligosaccharide 5.8%	fibact	Pierre 97	1.1	1	50	47	93		2.1	0.7	33	*	2.8	6	FOS
M193	rye bran 10% /inulin diet	fibact	Oikarinen 00	1.1	1	40	36	91							5.5	Rye
M194	vegetables-fruits mix. 20% in 9%fat	phyto	VanKranen 98	1.1	2	17	14	82		1.5	2.3	152		0.5	16/-3	Veg
M195	wheat bran 7%	fibact	Pierre 97	1.1	1	50	47	94		2.1	1.5	71		1.3	6	Whe
M196	PgEP4 ant. /Apc1309 400ppm	NSAI+	Kitamura 03	1.1	1	38	35	91							6	polyp area 43% reduction
M197	aspirin /Apc1638 300ppm	NSAI+	Williamson 99	1.1	2	2.38	2	91							20	Asp pooled +RS&-RS
M198	genistein /ovariectomized 0.001	other+	Javid 05	1.1	1	35	32	92		0.8	0.5	63		1.5	10	gen
M199	folic acid defic.0.3 vs.2ppm /min Rcf1+/+	vitB+	Lawrance 07	1.1	1	60	56	92							10 /+23	folic deficiency
M200	flaxseed 5%	phyto+	VanKranen 03	1.1	2	15	14	93		1.4	1.2	89		1.1	10	high lignans & isoflavones
M201	leptin 800æg/kg	other+	Aparicio 05	1.1	1	123	115	93		1.3	0.9	69		1.4	6	Lep
M202	mofez+nimes /Apc1309 600+400ppm	NSAI+	Kitamura 04	1.1	1	58	55	95							4	polyp area 37% reduction
M203	calcium, low (con./2) 0.25% vs 0.5%	miner+	Huerta 02	1.0	1	12	11	92		3.4	3.7	109		0.8	12	ca
M204	resveratrol 500ppm	phyto+	Sale Richard 04	1.0	1			97							14	res
M205	CLA-mix or -t10c12 1%	fat+	Mandir 08	1.0	2	72	77	106		9.1	3.3	36	*	2.9	8 /+42	CLA protect prox.sml.intest.
M206	arachidonic acid 1%	fat	Hansen-Pet. 02	1.0	1	54	55	101							7	Arach
M207	Citrobacter rodentium 10E8 cfu once	fibact	Newman 01	1.0	1	9	7	79		0.8	2.8	350	*	0.2	22	Citr
M208	fat high- LowFiber fat:cell. 22:0 vs.7:5%	fat	Mutanen 00	1.0	1	35	34	98		1.8	1.4	78		1.3	5.5	HF LF
M209	fiber high- chow fibr:fat 18:6 vs.0:20%	fibact	Yu Whiteley 01	1.0	1	29	28	96		0.4	1.1	271	*	0.4	9	chow
M210	methionine 0.7%	other	Paulsen 01	1.0	1	26	25	96		0.5	0.9	180		0.5	4	Met
M211	Ro26-9114 3 x 5 mcrg/wk	vitAD	Huerta 02	1.0	1	17	17	102		4.5	4.7	104		1.0	10	Ro26
M212	soy isoflavones 475ppm vs 16ppm	phyto	Sorensen 98	1.0	2	31	31	99							11	soy
M213	starch resistant- 19%	fibact	Pierre 97	1.0	1	50	50	99		2.1	3.0	143		0.7	6	starc
M214	sulindac /Apc1638Mlh1 200ppm	NSAI	Itano 04	1.0	1			100		0.1	1.0	1111	*	0.0	26	incidence data
M215	vit. D3 1a,25(OH)2-D3 3x0.01mcrg/wk	vitAD	Huerta 02	1.0	1	17	18	108		4.5	4.0	89		1.2	10	D3
M216	wheat bran 10%	fibact	Mutanen 00	1.0	1	35	35	99		1.8	2.1	117		0.9	5.5	Whe
M217	aspirin 25 mg/kg	NSAI+	Reuter 02	1.0	1	61	62	102		1.9	2.5	132		0.8	14	Asp
M218	secoisolariciresinol (lignan) 200ppm	phyto+	Pajari 06	0.9	1	51	54	106		0.5	0.4	80		1.3	10	seco
M219	celecoxib 0.15% for >3months	NSAI+	Carothers 06	0.9	1	33	35	106							18 /+42	cel No long-term protec
M220	ALA alpha linolenic ac. 3.1%	fat+	Hansen-Pet. 00	0.9	1	34	36	108		1.3	0.8	62		1.8	7	ALA
M221	caffeine 440ppm	phyto+	Ju Hong 05	0.9	1	29	31	107		0.7	0.8	114		0.9	6	caf
M222	caloric restr. -30% /Mlh1 -30%	other+	Tsao Dudley 02	0.9	1	2	2	108	*						43	CR
M223	exercise (wheel) 4.7km/d males	other+	Mehl 05	0.9	1	93	103	111							9	Exer
M224	cherry cyanidin/anthocyan. 2-800ppm	phyto+	Kang 03	0.9	2	58	65	112		3.7	3.4	92		1.2	10	sign.reduct. /cecal polyps
M225	aspirin 200ppm	NSAI	Sansom 01	0.9	1	34	39	115							19	Asp
M226	folate +choline 2ppm +3% vs 0+1.4%	combi	Sibani 02	0.9	3	29	33	114							10	Fol+cho
M227	PEG 8000 /MinMsh2 5%	PEG	Naigamwal. 00	0.9	1	12	13	104		0.0	0.7	3020	*	0.0	9	PEG
M228	PhiP /Apc716 400ppm	HAA	Oshima 96	0.9	1	147	168	114							8	PhiP
M229	PhiP 50mg/kg x 4 inj.	HAA	Steffensen 97	0.9	2	72	78	108		0.7	0.5	78		1.4	4	PhiP
M230	troglitazone Ppar-gam 150mg/kg/d	Ppar	Lefebvre 98	0.9	1	22	23	104		0.6	1.7	283	*	0.4	8	Trog
M231	fat high-corn oil 15% vs 5%	fat+	Mai Colbert 03	0.9	1	9	10	118		0.6	0.2	33		3.5	9	fat
M232	resveratrol 90mg/kg	phyto+	Ziegler 04	0.9	1	55	63	115		2.0	2.0	100		1.1	7	no effect of doses 4 & 20
M233	arginine 2%	/N+	Yerushalmi 06	0.9	1	41	47	114		0.5	0.9	172	*	0.7	10 /+42	arg
M234	VEGF inhib. AZD2171 5mg/kg/d late	other+	Goodlad 06	0.8	1	63	73	116		4.0	5.7	145		0.8	4 /+70	vegf late treated
M235	DFMO 0.5%+arginine vs. arginine 2%	/N+	Yerushalmi 06	0.8	1	47	56	120		0.9	0.5	55	*	2.2	10 /+42	dfm/+arg
M236	rye bran /male 30%	phyto+	VanKranen 03	0.8	1	63	76	120		2.8	2.8	100		1.2	10	high lignans
M237	calcium, high (con.x2) 1% vs 0.5%	miner+	Huerta 02	0.8	1	12	14	121		3.4	3.9	115		1.1	12	ca
M238	nimesulide cox2 /Apc1309 400ppm	NSAI+	Kitamura 04	0.8	1	58	70	120							4	polyp area 25% reduction
M239	aspirin 400ppm	NSAI+	Chiu 00	0.8	4	31	37	120							6	Asp
M240	rye bran insoluble fract. 8%	fibact+	Oikarinen 03	0.8	2	31	38	123		0.5	0.9	180		0.7	6	rye bran insoluble fract.
M241	vitamin mix low RDA/3	vitAD+	Bashir 04	0.8	1	58	72	123	*	1.6	2.2	140		0.9	8	vit
M242	ethanol 17.5% in water	other+	Roy Gulizia 02	0.8	1	27	37	138	*	4.7	2.4	51		2.7	10	eth
M243	5ASA or 4-ASA 500ppm	NSAI	Ritland 99	0.8	2	84	102	122							11	ASA
M244	bran oat 10%	fibact	Mutanen 00	0.8	1	35	47	133		1.8	1.8	100		1.3	5.5	Oat
M245	BRL49,653 20mg/kg/d	Ppar	Lefebvre 98	0.8	1	27	31	113		0.6	3.2	525	*	0.2	8	BRL49
M246	folate 2-8-20ppm	vitB	Song Medline 00	0.8	3	18	23	126		2.6	3.1	120		1.0	26 /+3	Fol
M247	inulin 10%	fibact	Pajari 02	0.8	1	55	68	123		0.6	1.3	211		0.6	9	Inulin
M248	troglitazone Ppar-gam 0.2%	Ppar	Saez Tonton. 98	0.8	1	67	78	116		1.0	3.0	300	*	0.4	5	Trog
M249	bexarotene 800ppm	vitAD+	Merkel 06	0.8	1	16	20	126							6.5	bex
M250	NOS2-/- vs NOS2+/+	/N+	Scott 01	0.8	1	34	44	129	*	1.8	1.3	72		1.8	18	N0S2-/-
M251	matairesinol (lignan) 200ppm	phyto+	Pajari 06	0.8	1	51	67	131		0.5	0.4	80		1.6	10	tum.size x1.17
M252	lithium 0.24%	miner+	Gould 03	0.8	1	20	25	126		0.9	2.2	244	*	0.5	9	+16% tumor diameter *
M253	CLA conjug.linoleic ac. 3%	fat+	Hansen-Pet. 00	0.8	1	34	45	135		1.3	1.1	85		1.6	7	CLA
M254	prostaglandin E2 2x 150mcg/d po	other+	Wang Wang 04	0.7	1	50	64	128	*	0.3	3.3	1000	*	0.1	7	PGE2 incr. Polyp size
M255	vitamin mix high=RDAx5 vit.RDA x 5	vitAD	Bashir 04	0.7	1	58	78	134	*	1.6	1.8	114		1.2	8	vit
M256	GLA gama linolenic ac. 3.1%	fat+	Hansen-Pet. 00	0.7	1	34	47	139		1.3	1.2	92		1.5	7	GLA
M257	rye bran 10%	fibact+	Oikarinen 03	0.7	2	31	42	135		0.5	1.3	260	*	0.5	6	rye
M258	folic acid defic.0.3 vs.2ppm /min Rcf1+/-	vitB+	Lawrance 07	0.7	1	30	43	141							10 /+23	folic deficiency
M259	corn oil 10% vs 3%	fat	Wasan 97	0.7	2	23	32	137	*	1.8	3.8	212	*	0.6	21-43	Oil
M260	DHA /Apc716 3% in male	fat	Oshima 95	0.7	1	193	278	144							7	DHA
M261	inulin 2.5%	fibact	Mutanen 00	0.7	1	35	49	140		1.8	2.4	133		1.0	5.5	Inulin
M262	meat beef 24%	other	Mutanen 00	0.7	1	35	53	150		1.8	3.2	178		0.8	5.5	meat
M263	rye bran water extract 8%	fibact+	Oikarinen 03	0.7	2	31	44	142	*	0.5	1.0	200	*	0.7	6	rye
M264	retinoic ac. allTrns /+PhIP 50ppm	vitAD+	Mollersen 04	0.7	1	99	142	143	*	0.9	1.5	167		0.9	7	tum.size x1.56
M265	sulindac /Apc1638 200ppm	NSAI	Itano 04	0.7	1	1			*	0.0	0.9	9200	*	0.0	26	incidence data
M266	folic acid defic.0.3 vs.2ppm /min Mthfr+/ñ	vitB+	Lawrance 07	0.7	2	32	48	149	*						10 /+23	folic deficiency
M267	wheat Araphoe, whole 50%	fibact+	Drankhan 03	0.7	1	24	36	155		0.6	0.4	78		2.0	10	low orthophenolic wheat
M268	CD4+45RBhi lymphocytes 3x10E5	other+	Rao Pouta. 06	0.6	1	57	91	160	*						once	lym
M269	vegetables-fruits mix. 22% in 20%fat	phyto	VanKranen 98	0.6	2	17	28	162	*	1.5	2.3	152		1.1	16/-3	Veg
M270	rye bran /female 30%	phyto+	VanKranen 03	0.6	1	60	101	170	*	2.0	1.9	95		1.8	10	high lignans
M271	ranolazine 2x30mg/kg/d ip	other+	Suckow 04	0.6	1	12	20	169	*						4	ran
M272	high-fat low-Ca 21-0.1vs.11-0.6% /Mlh1	fat+	Tsao Dudley 02	0.6	1	2	3	173	*						43	fat
M273	flaxseed 5%	phyto+	VanKranen 03	0.5	2	5	9	192	*	0.4	0.7	160		1.2	4	high lignans & isoflavones
M274	GW501516 PparDelta 10mg/kg	Ppar+	Gupta RA 04	0.5	1	28	55	193	*	1.4	1.7	121		1.6	6	5x increase in polyps >2mm
M275	Western diet highFat lowCa /min-p21--	fat+	Yang Mathew 01	0.5	1	4	7	192	*						36	75% deaths in W.d. fed p21--
M276	fructo-oligosacch. 5.8% inT-cell depletd	fibact	Pierre 99	0.5	1					0.4	0.8	200	*		6	FOS
M277	PhiP 10mg/kg x 1 inj.	HAA	Steffensen 01	0.5	2	47	88	188	*	0.6	0.9	157		1.2	9	PhiP
M278	prostaglandin E2 2x 300mcg/d po	other+	Wang Wang 04	0.5	1	50	101	200	*	0.3	2.2	667	*	0.3	7	PGE2 incr. Polyp size
M279	starch resistant- /Apc1638 20%	fibact+	Williamson 99	0.5	1	1.52	3	213	*						20	RS= H7+pota
M280	retinoic acid allTrans 10ppm	vitAD+	Mollersen 04	0.4	1	18	42	232	*	0.3	1.5	500	*	0.5	7	tum.size x1.2
M281	Western diet highFat lowCa /p27kip1	fat+	Yang Bancr. 03	0.4	1	1	3	246	*						36	tumors in wild mice fed W.diet
M282	PhiP /Apc1638 0.03% male&fem.	HAA	Sorensen 97	0.4	1	3	7	234	*						26	PhiP
M283	western diet Fat+ Ca- vit.D-/Apc1638	fat	Yang Edelm. 98	0.4	2					1.0	2.3	233			14-34	West
M284	Western diet vs AIN76 highFat lowCa	fat+	Yang Mathew 01	0.4	1	2	4	253	*						36	25% deaths in W.d. fed min
M285	X-irradiation 2Gy once	other+	Okamoto 05	0.4	1	78	210	270	*	3.5	16.8	480	*	0.6	once 11d	Xray
M286	N-OH-PhiP /Apc716 50mg/kg x 5 inj.	HAA	Oshima 96	0.3	1	17	57	335	*						5d/+4	PhiP
M287	PhiP 50mg/kg x 1 inj.	HAA	Steffensen 01	0.3	2	47	163	346	*	0.6	1.8	297	*	1.2	9	PhiP
M288	Western diet highFat lowCa + p21--	combi+	Yang Mathew 01	0.2	1	2	7	418	*						36	75% deaths in W.d. fed p21--
M289	folate /MinMsh2-- 8ppm	vitB	Song Sohn 00	0.2	1	70	295	422	*	2.4	2.4	100		4.2	5 /+6	Folate
M290	PhiP 25mg/kg x 8 inj.	HAA	Andreassen 01	0.2	1	30	157	524	*	0.6	0.9	145		3.6	pups 3	PhiP
M291	PhIP 50mg/kg 1sc.Inj.	HAA+	Mollersen 04	0.2	1	18	99	551	*	0.3	0.9	300	*	1.8	pups	PhIP
M292	sulindac /Mlh1 200ppm	NSAI	Itano 04	0.1	1			315		0.1	0.9	1517	*	0.2	26	incidence data
M293	PhiP 50mg/kg x 8 inj.	HAA	Andreassen 01	0.1	1	30	237	789	*	0.6	3.1	519	*	1.5	pups 3	PhiP
M294	DSS 4% in water	other	Cooper 01	0.0	2					1.7	24.2	1421	*		1	DSS
M	Ribes pallidum wh.currant frz-dry 10%	phyto+	Rajakangas 08	1.6	1	81	51	63	*	0.3	0.8	267	*	0.2	10	blind Ad.size reduc.1.26
M	EGCG 100ppm in water	phyto+	Sukhthankar 08	1.5	1	90	61	68	*						9	no bl egcg
M	cherry anthocyan. 300-3000ppm	phyto+	Bobe 06	1.3	4	38	29	77	*						19	no dose-sep.
M	zebularine 0.2mg/ml drnk.w. /females	other+	Yoo Chuang	43.3	1	59	1.4	2.3	*						16	no bl zeb
M	zebularine 0.2mg/ml drnk.w. /males	other+	Yoo Chuang	1.0	1	26	26	102							16	no bl zeb
M	methylclofenapate 1600ppm PPARa act.	Ppar+	Jackson 08	1.8	1	24	13	54	*	6.5	4.0	62	*	0.9	14	no bl mcfp
M	western diet Fat+ Ca- vit.D-/Apc1638	fat+	Yang Lampr. 08	0.5	1	1.5	3.0	204	*		0.2	615		0.3	24	West
M	Ca+vit.D vs West.Diet /Apc1638	miner+	Yang Lampr. 08	1.3	1	3.0	2.1	72	*	0.2	0.0	416		0.2	24	CaVD large protec on incid.
M	EGCG+genistein 0.01+0.2%	phyto+	Lambert 08	0.5	1	12	26	217	*						9	EGCG+Gen
M	PPAR ligand MCC-555 30mg/kg/d	Ppar+	Yamaguchi 08	1.8	1	125	69	55	*						4	no mcc5
M	styrylquinazoline CP-31398 200ppm	other+	Rao Swamy 08	4.1	1	41	10	24	*	1.2	0.2	17	*	1.5	11	blind p53
M	apple pomace 20%	fibact+	Mandir 08	0.4	1	41	100	244	*	2.4	2.0	83		2.9	8	apl
M	NO-aspirin 72ppm /Msh2floxfloxVpC++	/N+	Mcilhatton 11	0.9	1	1.6	1.7	106		0.0	0.1	175		0.6	60	NO-asp Increases life span
M	NO-aspirin 720ppm /Msh2floxfloxVpC++	/N+	Mcilhatton 11	0.3	1	1.6	4.9	313		0.0	0.1	150		2.1	60	NO-asp Decreases life span
M	aspirin 400ppm /Msh2floxfloxVpC++	NSAI+	Mcilhatton 11	1.1	1	1.6	1.4	90		0.0	0.1	200		0.4	60	asp Increases life span
M	quercetin 200ppm	phyto+	Murphy 11	3.0	1	48	14	28	*	1.4	2.8	200		0.1	16	que
M	apple polyphenol extract 20ppm/water	phyto+	Fini Piazzi 11	1.7	1	36.5	21.2	57.9	*	1.5	0.9	63		0.9	12	ape diet: WD
M	apple polyphenol extract 20ppm/water	phyto+	Fini Piazzi 11	1.5	1	25.7	16.9	65.9	*	0.9	0.3	34		2.0	12	APE diet: AIN93G

Corpet DE & Pierre F 2003, Cancer Epidemiol. Biomarkers Prevention, Updated 2008 - http://www.inra.fr/reseau-nacre/sci-memb/corpet/indexan.html

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