Prom-ACF

Prom-ACF, last modif.: 18 Sep 2012 - Data ranked by PromotionPotency - Click column header to sort table or click HERE to select filtering rules - Go BACK to get explanation about column headers.

Line #	In CONSTRUCTION Promoting agent or diet, and dose	Cate gory	Author, year (click name for abstract)	Potency/ACF = times-fold increase	Percent increase	Protocol	ACF No, con.	ACF No, treat.	Crypt /ACF con.	Crypt /ACF treat	Potency/ crypt per ACF	Potency/ Aberrant Crypts	Ro- dent	Carcinogen N x dose	Treat. weeks	Line #
P01	high-fat cafeteria (pate, bacon, choc.)	fat	Delage 05	9.06	806	both	21	192			1.10	9.97	Rw'	dmh 1x15	-4+4	P01
P02	ethanol 5% in liquid diet	other	Hayashi 07	7.33	633	both	1	4					Rw'	dmh 16x20	0+39	P02
P03	DSS 1.5% 2x1wk	dss	Nishikawa 05	5.73	473	post	12	69	1.17	1.62	1.38	7.93	Mc'	MeIQx 300ppmx12wks	+1+2	P03
P04	deoxycholic acid 0.25% /AKR/J mice	bile	Flynn 07	5.52	452	post	6	34					Ma'	aom 6x10	+1+4?	P04
P05	deoxycholic acid 0.25% /AKR/J mice	bile	Flynn 05	5.51	451	post	6.2	34					Ma	aom	+1+	P05
P06	calcium 0.32 vs 0.04% //MNU LFdiet	miner	Weisburger 94	3.20	220	both	129	413	2.61	2.72	1.04	3.33	Rf'	mnu 4x2mg	-1+8	P06
P07	exercise (swim to exhaustion)	other	Demarzo 04	2.92	192	init	3.7	11					Rw'	dmh 1x50	+0	P07
P08	fasted-refed (4d fast - 1d refed)	other	Caderni 99	2.67	167	init	4.5	12	2.70	3.19	1.18	3.15	Rf'	aom 1x7.5	-5d-1d	P08
P09	Orlistat 200ppm+ hi.fat 10% cotton oil	other	Garcia 05	2.67	167	?	6.2	17					Rw	dmh 2x25	?	P09
P10	gastrin-KO lean vs wild mice	insul	Cowey 05	2.60	160	both	2.3	5.9					M'	aom 3x8	-24+2	P10
P11	deoxycholic acid 0.25% /AKR/J mice	bile	Flynn 05	2.51	151	init	6.2	16					Ma	aom	-1+1	P11
P12	fish oil vs corn oil 7% /IL10 KO mice	fat	Hegazi 06	2.29	129	init	1.4	3.2	91	209	2.29	5.23	Mko'	none	+0+12	P12
P13	high-fat corn oil 23.5% vs.5%	fat	Kohno 00	2.16	116	both	22	47	1.20	1.68	1.40	3.02	Rf'	aom 3x15	-1+4	P13
P14	high-fat fish oil 23.5% vs.5%	fat	Kohno 00	2.02	102	both	17	34	1.47	1.50	1.02	2.07	Rf'	aom 3x15	-1+4	P14
P15	calcium low- 0.1% vs 0.5%	miner	Thiagaraj. 98	1.90	90	post	70	133	4.31	4.35	1.01	1.92	Rf'	aom 2x15	+1+13	P15
P16	Lactobacillus casei 2.5 10E6	fibact+	Bolognani 01	1.76	76	post	75	131					Rs'	dmh 1x60	-1+12	P16
P17	methionine L- 1%	prot	Duranton 99	1.75	75	post	20	35					Rw'	aom 2x15	+0+12	P17
P18	cholic acid 0.5% * MDF	bile	Femia 04	1.74	74	post	6.1	11	6.62	11.2	1.68	2.93	Rf'	aom 2x15	+1+10	P18
P19	oxothiazolidine carboxylate 0.2%	other	Wargovich 00	1.72	72	init	79	136					Rf'	aom 2x15	-1+5	P19
P20	Orlistat 200ppm	other	Garcia 05	1.71	71	?	6.2	11					Rw	dmh 2x25	?	P20
P21	high-fat 20% vs 5% lipid mix	fat	Rao Hirose01	1.67	67	both	109	182					Rf'	aom 2x15	-2+8	P21
P22	calcium 0.32 vs 0.04% //MNU HFdiet	miner	Weisburger 94	1.65	65	both	234	387	2.82	3.03	1.08	1.78	Rf'	mnu 4x2mg	-1+8	P22
P23	sitosterol (beta) 0.6%	other	Wargovich 96	1.65	65	init	83	137					Rf'	aom 2x15	-1+4	P23
P24	arsenite 50 vs 0.5 æg/g	other	Uthus 05	1.63	63	both	54	87	2.64	2.53	0.96	1.56	Rf'	dmh 2x25	-3+8	P24
P25	sulfasalazine 0.04%	other	Wargovich 96	1.62	62	init	78	126					Rf'	aom 2x15	-1+4	P25
P26	lutein 2000ppm	phyto	Raju 05	1.59	59	both	86	137	2.60	2.55	0.98	1.56	Rf'	aom 2x15	-2+7	P26
P27	high-fat safflower oil 25% vs.5%	fat	Delage 04	1.57	57	both	21	33	2.92	3.46	1.18	1.86	Rf'	dmh 1x15	-4+17	P27
P28	gastrin-KO obese vs KO lean mice	insul	Cowey 05	1.55	55	both	5.9	9.1					M'	aom 3x8	-24+2	P28
P29	deoxycholic acid 0.3% //dmh+dss	irrit	Onose 06	1.50	50	post	21	31					Rf'	dmh 3x40	+2+19	P29
P30	catechin +/- 0.5%	phyto	Wargovich 96	1.50	50	init	78	117					Rf'	aom 2x15	-1+4	P30
P31	benzyl isothiocyanate 0.1%	phyto	Wargovich 96	1.49	49	init	83	124					Rf'	aom 2x15	-1+4	P31
P32	B-carotene 2000ppm	phyto	Raju 05	1.44	44	both	86	124	2.60	2.60	1.00	1.44	Rf'	aom 2x15	-2+7	P32
P33	dehydroepiandosterone 0.2%	other	Wargovich 96	1.43	43	init	81	116					Rf'	aom 2x15	-1+4	P33
P34	blood sausage (boudin) 60%	hem	Pierre 04	1.43	43	post	72	103	2.67	2.94	1.10	1.57	Rf''	aom 1x20	+1+14	P34
P35	propyl gallate 0.16%	other	Wargovich 96	1.43	43	init	77	110					Rf'	aom 2x15	-1+4	P35
P36	hemoglobin 5%	hem	Bruce 93	1.40	40	post	164	229	4.24	4.88	1.15	1.61	Rf	aom 1x20	+1+14	P36
P37	meat beef- 60%	hem	Pierre 04	1.39	39	post	72	100	2.67	2.79	1.04	1.45	Rf''	aom 1x20	+1+14	P37
P38	high-fat corn oil 23% vs 5% * MDF *	fat	Femia 05	1.38	38	post	4.1	5.7	9.75	8.85	0.91	1.25	Rf'	dmh 2x150	+1+14	P38
P39	tea black- extract 1%	phyto	Wargovich 00	1.37	37	init	73	100					Rf'	aom 2x15	-1+5	P39
P40	DSS 1% 1wk	dss	Tanaka 01	1.37	37	init	84	115	2.00	2.40	1.20	1.64	Rf'	aom 2x20	-2-1	P40
P41	fecapentaene12 114ng/d	irrit	Zarkovic 93	1.34	34	post	10	13					Rf''	mnu 9x20	+5+29	P41
P42	soy 23% vs low isoflavone soy	phyto	Davies 99	1.34	34	both	125	167					Rf'	dmh 2x25	-3+8	P42
P43	meclofenamate Na 40mg/kg	other	Wargovich 00	1.33	33	init	103	137					Rf'	aom 2x15	-1+5	P43
P44	hemin 1.5 micromol/g	hem	Pierre 03	1.32	32	post	125	165	2.58	11.4	4.42	5.84	Rf''	aom 1x20	+1+14	P44
P45	hemoglobin 0.36micromol/g	hem	Pierre 03	1.30	30	post	125	162	2.58	3.18	1.23	1.60	Rf''	aom 1x20	+1+14	P45
P46	carbenoxolone 0.1%	other	Wargovich 00	1.29	29	post	182	235					Rf'	aom 2x15	+4+8	P46
P47	carbenoxolone 0.1%	other	Wargovich 00	1.27	27	init	240	304					Rf'	aom 2x15	-1+5	P47
P48	cooked casein 20%	prot	Zhang 92	1.23	23	post	116	143	2.51	3.63	1.45	1.78	Rf''	aom 1x20	+1+14	P48
P49	high-fat 22% vs 7% 15BT	fat	Morotomi 97	1.22	22	init	114	139	1.90	2.17	1.14	1.39	Rf'	aom 2x15	-1+6	P49
P50	tea green- extract 1%	phyto	Wargovich 00	1.20	20	init	120	144					Rf'	aom 2x15	-1+5	P50
P51	fasted-refed 5x(4d fast - 7d refed)	other	Caderni 02	1.12	12	post	40	45	2.40	4.30	1.79	2.02	Rf'	aom 1x20	+1+10	P51
P52	high-fat 37% vs 5% 32BT	fat	Koohesta. 97	1.09	9	post	112	122	2.49	3.57	1.43	1.56	Rf'	aom 1x20	+1+14	P52
P53	insulin injections 20 U/kg/d x72d	insul	Corpet 97	1.00		post	259	260	2.49	2.76	1.11	1.11	Rf''	aom 1x20	+1+14	P53
P54	high-fat corn oil 23% vs 5%	fat	Femia 05	0.95	-5	post	161	154	3.42	3.13	0.91	0.87	Rf'	dmh 2x150	+1+14	P54
P55	high-fat vs lowF /calor.restr-20%	fat	Lasko 95	0.94	-6	post	170	160	3.02	3.50	1.16	1.09	Rf'	aom 2x15	+11+23	P55
P56	cholic acid 0.5%	bile	Femia 04	0.87	-13	post	210	182	2.96	2.56	0.86	0.75	Rf'	aom 2x15	+1+10	P56
P57	cooked casein+fat 20+20%	prot	Corpet 90	0.79	-21	post	53	42	6.02	8.67	1.44	1.14	Rf''	aom 1x30	+1+14	P57
P58	bisacodyl 43mg/kg	irrit	Borrelli 01	0.78	-22	both	135	105	3.00	4.44	1.48	1.15	Rw'	aom 2x15	+0+13	P58
P59	Senna extract 100mg/kg	irrit	Mascolo 99	0.75	-25	both	131	98	2.50	4.20	1.68	1.26	Rw'	aom 2x15	+0+13	P59
P60	carrageenan 2.5% in water	irrit	Corpet 97	0.64	-36	post	86	55	2.98	3.44	1.15	0.74	Rf''	aom 1x20	+1+14	P60
P61	carrageenan 2.5%water	irrit	Tache 00	0.64	-36	post	86	55	2.98	3.44	1.15	0.74	Rf''	aom 1x20	+1+14	P61
P62	cooked casein 12.5%	prot	Corpet Cas95	0.63	-37	post	128	81	3.20	4.10	1.28	0.81	Rf'	aom 1x20	+1+14	P62
P63	cholic acid 0.2%	bile	Magnuson 93	0.45	-55	both	165	74	2.90	3.63	1.25	0.56	Rs'	aom 2x20	+0+8	P63

Line #

In CONSTRUCTION
Promoting agent
or diet, and dose

Cate
gory

Author, year
(click name
for abstract)

Potency/ACF
= times-fold
increase

Percent
increase

Protocol

ACF
No,
con.

ACF
No,
treat.

Crypt
/ACF
con.

Crypt
/ACF
treat

Potency/
crypt per
ACF

Potency/
Aberrant
Crypts

Ro-
dent

Carcinogen
N x dose

Treat.
weeks

Line #

P01

high-fat cafeteria (pate, bacon, choc.)

fat

Delage 05

9.06

806

both

192

1.10

9.97

Rw'

dmh 1x15

-4+4

P01

P02

ethanol 5% in liquid diet

other

Hayashi 07

7.33

633

both

Rw'

dmh 16x20

0+39

P02

P03

DSS 1.5% 2x1wk

dss

Nishikawa 05

5.73

473

post

1.17

1.62

1.38

7.93

Mc'

MeIQx 300ppmx12wks

+1+2

P03

P04

deoxycholic acid 0.25% /AKR/J mice

bile

Flynn 07

5.52

452

post

Ma'

aom 6x10

+1+4?

P04

P05

deoxycholic acid 0.25% /AKR/J mice

bile

Flynn 05

5.51

451

post

6.2

aom

+1+

P05

P06

calcium 0.32 vs 0.04% //MNU LFdiet

miner

Weisburger 94

3.20

220

both

129

413

2.61

2.72

1.04

3.33

Rf'

mnu 4x2mg

-1+8

P06

P07

exercise (swim to exhaustion)

other

Demarzo 04

2.92

192

init

3.7

Rw'

dmh 1x50

P07

P08

fasted-refed (4d fast - 1d refed)

other

Caderni 99

2.67

167

init

4.5

2.70

3.19

1.18

3.15

Rf'

aom 1x7.5

-5d-1d

P08

P09

Orlistat 200ppm+ hi.fat 10% cotton oil

other

Garcia 05

2.67

167

6.2

dmh 2x25

P09

P10

gastrin-KO lean vs wild mice

insul

Cowey 05

2.60

160

both

2.3

5.9

aom 3x8

-24+2

P10

P11

deoxycholic acid 0.25% /AKR/J mice

bile

Flynn 05

2.51

151

init

6.2

aom

-1+1

P11

P12

fish oil vs corn oil 7% /IL10 KO mice

fat

Hegazi 06

2.29

129

init

1.4

3.2

209

2.29

5.23

Mko'

none

+0+12

P12

P13

high-fat corn oil 23.5% vs.5%

fat

Kohno 00

2.16

116

both

1.20

1.68

1.40

3.02

Rf'

aom 3x15

-1+4

P13

P14

high-fat fish oil 23.5% vs.5%

fat

Kohno 00

2.02

102

both

1.47

1.50

1.02

2.07

Rf'

aom 3x15

-1+4

P14

P15

calcium low- 0.1% vs 0.5%

miner

Thiagaraj. 98

1.90

post

133

4.31

4.35

1.01

1.92

Rf'

aom 2x15

+1+13

P15

P16

Lactobacillus casei 2.5 10E6

fibact+

Bolognani 01

1.76

post

131

Rs'

dmh 1x60

-1+12

P16

P17

methionine L- 1%

prot

Duranton 99

1.75

post

Rw'

aom 2x15

+0+12

P17

P18

cholic acid 0.5% * MDF

bile

Femia 04

1.74

post

6.1

6.62

11.2

1.68

2.93

Rf'

aom 2x15

+1+10

P18

P19

oxothiazolidine carboxylate 0.2%

other

Wargovich 00

1.72

init

136

Rf'

aom 2x15

-1+5

P19

P20

Orlistat 200ppm

other

Garcia 05

1.71

6.2

dmh 2x25

P20

P21

high-fat 20% vs 5% lipid mix

fat

Rao Hirose01

1.67

both

109

182

Rf'

aom 2x15

-2+8

P21

P22

calcium 0.32 vs 0.04% //MNU HFdiet

miner

Weisburger 94

1.65

both

234

387

2.82

3.03

1.08

1.78

Rf'

mnu 4x2mg

-1+8

P22

P23

sitosterol (beta) 0.6%

other

Wargovich 96

1.65

init

137

Rf'

aom 2x15

-1+4

P23

P24

arsenite 50 vs 0.5 æg/g

other

Uthus 05

1.63

both

2.64

2.53

0.96

1.56

Rf'

dmh 2x25

-3+8

P24

P25

sulfasalazine 0.04%

other

Wargovich 96

1.62

init

126

Rf'

aom 2x15

-1+4

P25

P26

lutein 2000ppm

phyto

Raju 05

1.59

both

137

2.60

2.55

0.98

1.56

Rf'

aom 2x15

-2+7

P26

P27

high-fat safflower oil 25% vs.5%

fat

Delage 04

1.57

both

2.92

3.46

1.18

1.86

Rf'

dmh 1x15

-4+17

P27

P28

gastrin-KO obese vs KO lean mice

insul

Cowey 05

1.55

both

5.9

9.1

aom 3x8

-24+2

P28

P29

deoxycholic acid 0.3% //dmh+dss

irrit

Onose 06

1.50

post

Rf'

dmh 3x40

+2+19

P29

P30

catechin +/- 0.5%

phyto

Wargovich 96

1.50

init

117

Rf'

aom 2x15

-1+4

P30

P31

benzyl isothiocyanate 0.1%

phyto

Wargovich 96

1.49

init

124

Rf'

aom 2x15

-1+4

P31

P32

B-carotene 2000ppm

phyto

Raju 05

1.44

both

124

2.60

1.00

1.44

Rf'

aom 2x15

-2+7

P32

P33

dehydroepiandosterone 0.2%

other

Wargovich 96

1.43

init

116

Rf'

aom 2x15

-1+4

P33

P34

blood sausage (boudin) 60%

hem

Pierre 04

1.43

post

103

2.67

2.94

1.10

1.57

Rf''

aom 1x20

+1+14

P34

P35

propyl gallate 0.16%

other

Wargovich 96

1.43

init

110

Rf'

aom 2x15

-1+4

P35

P36

hemoglobin 5%

hem

Bruce 93

1.40

post

164

229

4.24

4.88

1.15

1.61

aom 1x20

+1+14

P36

P37

meat beef- 60%

hem

Pierre 04

1.39

post

100

2.67

2.79

1.04

1.45

Rf''

aom 1x20

+1+14

P37

P38

high-fat corn oil 23% vs 5% * MDF *

fat

Femia 05

1.38

post

4.1

5.7

9.75

8.85

0.91

1.25

Rf'

dmh 2x150

+1+14

P38

P39

tea black- extract 1%

phyto

Wargovich 00

1.37

init

100

Rf'

aom 2x15

-1+5

P39

P40

DSS 1% 1wk

dss

Tanaka 01

1.37

init

115

2.00

2.40

1.20

1.64

Rf'

aom 2x20

-2-1

P40

P41

fecapentaene12 114ng/d

irrit

Zarkovic 93

1.34

post

Rf''

mnu 9x20

+5+29

P41

P42

soy 23% vs low isoflavone soy

phyto

Davies 99

1.34

both

125

167

Rf'

dmh 2x25

-3+8

P42

P43

meclofenamate Na 40mg/kg

other

Wargovich 00

1.33

init

103

137

Rf'

aom 2x15

-1+5

P43

P44

hemin 1.5 micromol/g

hem

Pierre 03

1.32

post

125

165

2.58

11.4

4.42

5.84

Rf''

aom 1x20

+1+14

P44

P45

hemoglobin 0.36micromol/g

hem

Pierre 03

1.30

post

125

162

2.58

3.18

1.23

1.60

Rf''

aom 1x20

+1+14

P45

P46

carbenoxolone 0.1%

other

Wargovich 00

1.29

post

182

235

Rf'

aom 2x15

+4+8

P46

P47

carbenoxolone 0.1%

other

Wargovich 00

1.27

init

240

304

Rf'

aom 2x15

-1+5

P47

P48

cooked casein 20%

prot

Zhang 92

1.23

post

116

143

2.51

3.63

1.45

1.78

Rf''

aom 1x20

+1+14

P48

P49

high-fat 22% vs 7% 15BT

fat

Morotomi 97

1.22

init

114

139

1.90

2.17

1.14

1.39

Rf'

aom 2x15

-1+6

P49

P50

tea green- extract 1%

phyto

Wargovich 00

1.20

init

120

144

Rf'

aom 2x15

-1+5

P50

P51

fasted-refed 5x(4d fast - 7d refed)

other

Caderni 02

1.12

post

2.40

4.30

1.79

2.02

Rf'

aom 1x20

+1+10

P51

P52

high-fat 37% vs 5% 32BT

fat

Koohesta. 97

1.09

post

112

122

2.49

3.57

1.43

1.56

Rf'

aom 1x20

+1+14

P52

P53

insulin injections 20 U/kg/d x72d

insul

Corpet 97

1.00

post

259

260

2.49

2.76

1.11

Rf''

aom 1x20

+1+14

P53

P54

high-fat corn oil 23% vs 5%

fat

Femia 05

0.95

-5

post

161

154

3.42

3.13

0.91

0.87

Rf'

dmh 2x150

+1+14

P54

P55

high-fat vs lowF /calor.restr-20%

fat

Lasko 95

0.94

-6

post

170

160

3.02

3.50

1.16

1.09

Rf'

aom 2x15

+11+23

P55

P56

cholic acid 0.5%

bile

Femia 04

0.87

-13

post

210

182

2.96

2.56

0.86

0.75

Rf'

aom 2x15

+1+10

P56

P57

cooked casein+fat 20+20%

prot

Corpet 90

0.79

-21

post

6.02

8.67

1.44

1.14

Rf''

aom 1x30

+1+14

P57

P58

bisacodyl 43mg/kg

irrit

Borrelli 01

0.78

-22

both

135

105

3.00

4.44

1.48

1.15

Rw'

aom 2x15

+0+13

P58

P59

Senna extract 100mg/kg

irrit

Mascolo 99

0.75

-25

both

131

2.50

4.20

1.68

1.26

Rw'

aom 2x15

+0+13

P59

P60

carrageenan 2.5% in water

irrit

Corpet 97

0.64

-36

post

2.98

3.44

1.15

0.74

Rf''

aom 1x20

+1+14

P60

P61

carrageenan 2.5%water

irrit

Tache 00

0.64

-36

post

2.98

3.44

1.15

0.74

Rf''

aom 1x20

+1+14

P61

P62

cooked casein 12.5%

prot

Corpet Cas95

0.63

-37

post

128

3.20

4.10

1.28

0.81

Rf'

aom 1x20

+1+14

P62

P63

cholic acid 0.2%

bile

Magnuson 93

0.45

-55

both

165

2.90

3.63

1.25

0.56

Rs'

aom 2x20

+0+8

P63