Chemoprevention of colon cancer: metaanalysis & systematic review of preclinical studies in rats & mice
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Meta-Analysis of Chemoprevention Studies with
Aspirin, Beta-Carotene, Calcium and Wheat Bran
in Carcinogen-Initiated Rats and in Min Mice.

To quote the Meta-Analysis, cite: Corpet D.E. & Pierre F., 2005, European Journal of Cancer, 41: 1911-1922.
How good are Rodent Models of Carcinogenesis in Predicting Efficacy in Humans? Systematic Review and Meta-Analysis of Colon Tumour Chemoprevention in Rats, Mice and Men. [EJC reprint].pdf

EJC article major figure, comparing chemoprevention in men & rats,
or men & mice: screen size or full sizeChemoprevention Colon Tumor in Men Rats Mice

Abstract: To know if rodent models of colon carcinogenesis are good predictors of chemopreventive efficacy in humans, we made a meta-analysis of aspirin, beta-carotene, calcium, and wheat bran studies. Controlled intervention studies of adenoma recurrence in human volunteers were compared with chemoprevention studies of carcinogen-induced tumours in rats, and of polyps in Min (Apc(+/-)) mice: 6714 volunteers, 3911 rats and 458 mice were included in the meta-analyses. Difference between models was small since most global relative risks were between 0.76 and 1.00. A closer look showed that carcinogen-induced rat studies matched human trials for aspirin, calcium, carotene, and were compatible for wheat bran. Min mice results were compatible with human results for aspirin, but discordant for calcium and wheat bran (no carotene study). These few results suggest that rodent models roughly predict effect in humans, but the prediction is not accurate for all agents. Based on three cases only, the carcinogen-induced rat model seems better than the Min mouse model. However, rodent studies are useful to screen potential chemopreventive agents, and to study mechanisms of carcinogenesis and chemoprevention.

Abbreviations in Data Tables - Meta-Analysis Methods

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DE Corpet & F Pierre, 2005, European J. Cancer (accepted MS, June 05)
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