Chemoprevention of colon cancer: metaanalysis & systematic review of preclinical studies in rats & mice
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Meta-Analysis of Chemoprevention Studies with Wheat Bran
in Carcinogen-Initiated Rats and in Min Mice.

Figures from Rat Table <:3 )~~ and Mouse Table

Wheat Bran Chemoprevention Colon Tumor Incidence in Rats. Funnel plot Calcium Chemoprevention Colon Tumor Incidence in Rats. Wheat Bran Chemoprevention in High Fat diets, in Rats. Wheat Bran Chemoprevention in Low Fat diets, in Rats <:3 )~~ Wheat Bran Chemoprevention Colon Tumor number in Min mice. Wheat Bran Funnel Plot Min mice.

Identical figures below as above, but "Text links" instead of "Icon links"

An Explanation of Data Presented Above

Wheat bran effect in carcinogen-injected rats. A significant protection by wheat bran is shown in only two studies out of twelve publications [Table]. Meta-analysis, including 1164 rats, showed that wheat bran reduces colon tumour incidence in rats (RR= 0.83, p=0.0002) [Table], with similar RR in Random model analysis (0.87, p=0.015) [Figure]. The hypothesis that wheat bran specifically prevents fat promotion was tested by analysing separately studies with high fat and low fat diets. Wheat bran indeed protected rats given a high-fat diet (RR= 0.79, p=0.006) [HF figure], but not rats given a low-fat diet [LF figure].
Wheat bran effect in mutated mice. The eight studies gathering 147 Min mice showed a protective effect of wheat bran [Table]. Number of small intestinal polyps in wheat bran-fed mice was 69% of control number (weighted mean, 66%, p=0.001) [Table], and effect size was -0.74 by Random model analysis (p<0.001) [Figure]. Bran also marginally decreased colonic tumours (p=0.07, see Fig.1 in [preprint]).
Extracted from the article: "Corpet D.E. & Pierre F., 2005, European Journal of Cancer, How good are Rodent Models of Carcinogenesis in Predicting Efficacy in Humans? Systematic Review and Meta-Analysis of Colon Tumour Chemoprevention in Rats, Mice and Men. in the press." Fetch the [preprint] (.pdf)

Abbreviations /Data Tables

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DE Corpet & F Pierre, 2005, European J. Cancer
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