Documentation on MAN Data. [Full Doc]

• [Man] table shows efficacy of agents or diets to reduce adenomatous polyp recurrence (Adeno. rec.) or Colorectal Cancer incidence in humans (CRC incid.) - Other end-points have been used in some studies.
• RR = 0.50 means that the agent halved the tumor endpoint, e.g., It reduced polyp recurrence in treated group to 50% of control group value.
  1.00 denotes a no effect treatment. 1.20-1.60 means treatment had a tumor enhancing effect (promotion)
• Study Qual. (study quality):
  [!] denotes a human value not firmly established, because from a small size trial, or because the primary end point was not colon tumor.
  [top] studies have no major flaw, according to the author of this site (see home page bottom).
  [! NP], No Placebo given to controls (thus not a double-blind study);
  [! EP], EndPoint: primary end-point was not Adenomatous polyp recurrence or Colorectal Cancer incidence;
  [! SS], small study with not enough treated volunteers to yield solid data (N<99);
  [! NR], No Randomization: volunteers choose their treatment;
  [! WI], Weak Intervention: dietary advices were given but change was small;
  [! AB], Abstract: not yet published.
  
  
• Fetch Full Explanations on the [Man] table.
  See also comments on the discrepancies between human's and rodent's studies, and full [Meta-Analysis] study of aspirin, calcium, wheat brand and beta-carotene effect in men, rats, and mice.