Colonic Adenoma Reccurence Prevention, Chemoprevention Database
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Documentation on MAN Data. [Full Doc]
- [Man] table shows efficacy of agents or diets to reduce adenomatous polyp recurrence (Adeno. rec.) or Colorectal Cancer incidence in humans (CRC incid.) - Other end-points have been used in some studies.
- RR = 0.50 means that the agent halved the tumor endpoint, e.g., It reduced polyp recurrence in treated group to 50% of control group value.
1.00 denotes a no effect treatment. 1.20-1.60 means treatment had a tumor enhancing effect (promotion)
- Study Qual. (study quality):
[!] denotes a human value not firmly established, because from a small size trial, or because the primary end point was not colon tumor.
[top] studies have no major flaw, according to the author of this site (see home page bottom).
[! NP], No Placebo given to controls (thus not a double-blind study);
[! EP], EndPoint: primary end-point was not Adenomatous polyp recurrence or Colorectal Cancer incidence;
[! SS], small study with not enough treated volunteers to yield solid data (N<99);
[! NR], No Randomization: volunteers choose their treatment;
[! WI], Weak Intervention: dietary advices were given but change was small;
[! AB], Abstract: not yet published.
- Fetch Full Explanations on the [Man] table.
See also comments on the discrepancies between human's and rodent's studies, and full [Meta-Analysis] study of aspirin, calcium, wheat brand and beta-carotene effect in men, rats, and mice.
Corpet DE & Taché S, 2002, Nutrition & Cancer - & - DE Corpet & F Pierre, 2003, Cancer Epidemiol. Biomarkers Prevention.
E-mail: . Sites: Chemoprevention Database & Mirror site