| line # | Agent or Diet | Study Qual. | Reference (click name for abstract) | - RR - | Relative Risk (95% conf.int.) | size: treated number | Length, months | Daily dose | Fem. Male Both | Colon endpoint | Primary endpoint | . | Weighed mean /agent | Agent |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| H01 | DFMO+sulindac | top | Meyskens 08 | 0.3 | 0.30 (0.18-0.49) | 138 | 36 | 500+150 | B | Adeno. rec. | 0.3 | D+sul | ||
| H02 | dry bean | ! NR | Lanza 06 | 0.35 | 0.35 (0.18-0.69) | 1000? | 36 | 32g/d | B | Adv.adeno. rec. | Adeno. rec. | 0.35 | bean | |
| H03 | Lactulose | ! NP | Roncucci 93 | 0.41 | 0.41 (0.21-0.81) | 61 | 18 | 20 g | B | Adeno. rec. | 0.41 | Lac | ||
| H04 | Selenium | ! EP | Clark 96 | 0.42 | 0.42 (0.18-0.95) | 653 | 54 | 200 æg | B | CRC incid. | Skin cancer | 0.64 | Se | |
| H05 | Se,Ca,vitC,vitE,Bcar | ! SS | Hofstad 98 | 0.71 | 0.71 (0.5-1.0) | 42 | 36 | 100æg+1.6 g | B | Adeno. rec. | Polyp growth | 0.64 | SeMix | |
| H06 | Se,Zn,vitC,vitE,Bcar | ! EP | Hercberg 04 | 0.71 | 0.71 (0.39-1.31) | 2520 | 90 | 100æg+176mg | M | CRC incid. | All cancers | 0.64 | SeMix | |
| H07 | Sulindac sulfide | ! EP | Arber 06 | 0.65 | 0.65 (0.43-0.99) | 33 | 12 | 400 mg | B | Therap.resp. | Polyp size | 0.65 | ExS | |
| H08 | cox Celecoxib | top | Bertagnolli 06 | 0.67 | 0.67 (0.59-0.77) | 685 | 36 | 400 mg | B | Adeno. rec. | 0.67 | cox | ||
| H09 | cox Celecoxib | top | Bertagnolli 06 | 0.55 | 0.55 (0.48-0.64) | 671 | 36 | 800 mg | B | Adeno. rec. | 0.67 | cox | ||
| H10 | cox Celecoxib | top | Arber 06 | 0.64 | 0.64 (0.56-0.75) | 933 | 36 | 400 mg | B | Adeno. rec. | 0.67 | cox | ||
| H11 | cox Celecoxib | ! SS | Steinbach 00 | 0.72 | 0.72 polyp/patient | 30FAP | 6 | 800 mg | B | Polyp no. | Polyp numbr | 0.67 | cox | |
| H12 | cox Rofecoxib | top | Baron 06 | 0.76 | 0.76 (0.69-0.83) | 1277 | 36 | 25 mg | B | Adeno. rec. | 0.67 | cox | ||
| H13 | Sulindac | ! SS | Giardiello 02 | 0.78 | 0.78 (0.4-1.5) | 21FAP | 48 | 300 mg | B | Polyp no. | Polyp numbr | 0.78 | Sul | |
| H14 | Calcium | top | Bonithon 00 | 0.66 | 0.66 (0.38-1.17) | 176 | 36 | 2 g | B | Adeno. rec. | 0.79 | Ca | ||
| H15 | Calcium | top | Baron 99 | 0.85 | 0.85 (0.74-0.98) | 464 | 18 | 1.2 g | B | Adeno. rec. | 0.79 | Ca | ||
| H16 | Calcium +Mix | ! SS | Hofstad 98 | 0.71 | 0.71 (0.5-1.0) | 42 | 36 | 1.6 g | B | Adeno. rec. | Polyp growth | 0.79 | Ca | |
| H17 | Aspirin | ! EP | Gann 93 | 0.86 | 0.86 (0.68-1.10) | 11035 | 60 | 162 mg | M | Adeno. Incid. | Cardiovasc. | 0.85 | Asp | |
| H18 | Aspirin | ! SS | Benamouzig 03 | 0.61 | 0.61 (0.37-0.99) | 60 | 12 | 300 mg | B | Adeno. rec. | 0.85 | Asp | ||
| H19 | Aspirin | top | Sandler 03 | 0.65 | 0.65 (0.46-0.91) | 317 | 31 | 325 mg | B | Adeno. rec. | 0.85 | Asp | ||
| H20 | Aspirin | top | Baron 03 | 0.81 | 0.81 (0.69-0.96) | 377 | 33 | 81 mg | B | Adeno. rec. | 0.85 | Asp | ||
| H21 | Aspirin | top | Logan 08 | 0.79 | 0.79 (0.63-0.99) | 434 | 30 | 300 mg | B | Adeno. rec. | 0.85 | Asp | ||
| H22 | Aspirin | ! SS | Benamouzig 03 | 0.85 | 0.85 (0.57-1.26) | 66 | 12 | 160 mg | B | Adeno. rec. | 0.85 | Asp | ||
| H23 | Aspirin | top | Baron 03 | 0.96 | 0.96 (0.81-1.13) | 372 | 33 | 325 mg | B | Adeno. rec. | 0.85 | Asp | ||
| H24 | Lactobacilus casei | ! NP | Ishikawa 05 | 0.85 | 0.85 (0.56-1.27) | 192 | 48 | 3x10E10 | M | Adeno. rec. | 0.85 | L.cas | ||
| H25 | Ursodeoxycholic acid | top | Alberts 05 | 0.88 | 0.88 (0.73-1.05) | 661 | 32 | 8-10 mg/kg | B | Adeno. rec. | 0.88 | Urso | ||
| H26 | Wheat bran | top | Alberts 00 | 0.88 | 0.88 (0.7-1.1) | 719 | 35 | +11 g | B | Adeno. rec. | 0.98 | bran | ||
| H27 | Wheat bran | top | McKeown 94 | 1.2 | 1.2 (0.6-2.2) | 99 | 24 | +15 g | B | Adeno. rec. | 0.98 | bran | ||
| H28 | Wheat bran | top | MacLennan 95 | 1.2 | 1.2 (0.8-2.0) | 150 | 48 | +25 g | B | Adeno. rec. | 0.98 | bran | ||
| H29 | Wheat bran | ! NP | Ishikawa 05 | 1.31 | 1.31 (0.87-1.97) | 191 | 48 | 7.5 g | M | Adeno. rec. | 0.98 | bran | ||
| H30 | Beta-carotene | ! EP | Malila 99 | 0.98 | 0.98 (0.71-1.35) | 7761 | 78 | 20 mg | M | Adeno. Incid. | Lung cancer | 1.01 | Bcar | |
| H31 | Beta-carotene | top | Greenberg 94 | 1.01 | 1.01 (0.85-1.20) | 359 | 48 | 25 mg | B | Adeno. rec. | 1.01 | Bcar | ||
| H32 | Beta-carotene | top | MacLennan 95 | 1.5 | 1.5 (0.9-2.5) | 156 | 48 | 20 mg | B | Adeno. rec. | 1.01 | Bcar | ||
| H33 | Beta-carotene | ! EP | Hennekens 96 | 1 | 1 not signif. | 11035 | 144 | 25 mg | M | All cancers | Cardiovasc. | 1.01 | Bcar | |
| H34 | Aspirin | ! EP | Cook 05 | 0.97 | 0.97 (0.77-1.24) | 19934 | 121 | 50 mg | F | CRC incid. | All cancers | 1.04 | Asp | |
| H35 | Aspirin | ! NR | Sturmer 98 | 1.07 | 1.07 (0.67-1.70) | 3489 | 144 | 162 mg | M | CRC incid. | All cancers | 1.04 | Asp | |
| H36 | Aspirin | ! EP | Gann 93 | 1.15 | 1.15 (0.80-1.65) | 11037 | 60 | 162 mg | M | CRC incid. | Cardiovasc. | 1.04 | Asp | |
| H37 | Fruits & veg. | top | Schatzkin 00 | 1 | 1.00 (0.90-1.12) | 958 | 36 | +2serv | B | Adeno. rec. | 1.07 | F&V | ||
| H38 | Fruits & veg. | ! WI | Beresford 06 | 1.08 | 1.08 (0.90-1.29) | 19541 | 97 | +1.3serv | F | CRC incid. | 1.07 | F&V | ||
| H39 | Calcium +vit.D3 | top | Wactawski 06 | 1.08 | 1.08 (0.86-1.34) | 18176 | 84 | 1 g +400 UI | F | CRC incid. | Hip fracture | 1.08 | Ca | |
| H40 | Low fat | top | MacLennan 95 | 0.9 | 0.9 (0.6-1.5) | 151 | 48 | -7% | B | Adeno. rec. | 1.08 | Lfat | ||
| H41 | Low fat | top | Schatzkin 00 | 1 | 1.00 (0.90-1.12) | 958 | 36 | -10% | B | Adeno. rec. | 1.08 | Lfat | ||
| H42 | Low fat | top | McKeown 94 | 1.2 | 1.2 (0.6-2.2) | 99 | 24 | -9% | B | Adeno. rec. | 1.08 | Lfat | ||
| H43 | Low fat | top | Beresford 06 | 1.08 | 1.08 (0.90-1.29) | 19541 | 97 | -11% | F | CRC incid. | 1.08 | Lfat | ||
| H44 | Vit.C + vit.E | ! SS | McKeown 88 | 0.86 | 0.86 (0.51-1.45) | 70 | 24 | 0.4+0.4 g | B | Adeno. rec. | 1.1 | VitCE | ||
| H45 | Vit.C + vit.E | top | Greenberg 94 | 1.08 | 1.08 (0.91-1.29) | 380 | 48 | 1+0.4 g | B | Adeno. rec. | 1.1 | VitCE | ||
| H46 | Vit.C +vit.E +vit.A | ! NP | Roncucci 93 | 0.16 | 0.16 (0.06-0.43) | 70 | 18 | 1 g +70+9mg | B | Adeno. rec. | 1.1 | VitCEA | ||
| H47 | Vit.E | ! EP | Malila 99 | 1.66 | 1.66 (1.19-2.32) | 7768 | 78 | 50 mg | M | Adeno. Incid. | Lung cancer | 1.1 | VitE | |
| H48 | Vit.E | ! EP | Lee 05 | 1 | 1.00 (0.77-1.31) | 19937 | 121 | 200 mg | F | CRC incid. | Cardiovasc. | 1.1 | VitE | |
| H49 | Folic +B6+B12 | ! EP | Lonn 06 | 1.36 | 1.36 (0.89-2.08) | 2758 | 60 | 2.5+50+1 | B | CRC incid. | Cardiovasc. | 1.22 | Fol | |
| H50 | Folic acid | top | Cole 07 | 1.04 | 1.04 (0.90-1.20) | 501 | 36 | 1 mg | B | Adeno. rec. | 1.22 | Fol | ||
| H51 | Folic acid | top | Logan 08 | 1.07 | 1.07 (0.85-1.34) | 432 | 30 | 0.5 mg | B | Adeno. rec. | 1.22 | Fol | ||
| H52 | Folic acid | ! SS | Jaszewski 08 | 0.44 | 0.44 ade/patient | 46 | 36 | 5 mg | M | Adenoma no. | 1.22 | Fol | ||
| H53 | Psyllium | top | Bonithon 00 | 1.67 | 1.67 (1.01-2.76) | 198 | 36 | 3.5 g | B | Adeno. rec. | 1.67 | psyl | ||
| H | Aspirin MetaAnalysis | M-A | Cole-Logan 09 | 0.83 | 0.83 (0.72-0.96) | 2698 | 33 | 81 to 325 | Both | Adeno. rec. | 0.83 | Asp | ||
| H | EPA eicosapentaenoic FFA | !SS | West-Clark 10 | 0.88 | 0.88 polyp/patient | 28FAP | 6 | 2 g | B | Polyp no. | EPA | |||
| H | green tea extracts | ! SS | Shimizu 08 | 0.49 | 0.49 (0.24-0.99) | 71 | 12 | 1.5 g | B | Adeno. rec. | GTE | |||
| H | Aspirin | [! SS] | Bum Bishop 11 | 0.77 | 0.77 (0.54-1.10) | 62FAP | 17 | 600 mg | B | polyps no. | polyps no. | asp | ||
| H | Resistant starch | [! SS] | Bum Bishop 11 | 1.05 | 1.05 (0.73-1.49) | 61 | 17 | 30 g | B | polyps no. | polyps no. | |||
| M | curcumin | [! SS] | Carroll 11 | 0.62 | 11 ACF vs. 18 ACF | 19 | 1 | 4 g | B | ACF no. | PGE2/ACF |
To download data in Excel: select data (Ctrl-A), copy/paste (Ctrl-C) in an empty Excel page (Ctrl-V)