Rat-Aspirin

Rat-Aspirin, last modif.: 21 Sep 2011 - Data ranked by Year - Click column header to sort table or click HERE to select filtering rules - Go BACK to get explanation about column headers.

TREATMENT dose	Author, year (click name for abstract)	No. tumor bearing rats Controls	Total no. of rats Controls	No. tumor bearing rats Treated	Total no. of rats Treated	- - RR - -	p	Potency on tumor incidence	Tumor percent inhibition	Protocol	Ro- dents	Carcinogen N x dose	weeks
aspirin 10 ppm	Craven 92	6	12	2	12	0.34	NS	2.94	66	init	Rs'	dmh 1x30	36
aspirin 50 ppm	Craven 92	5	12	5	12	1.00	NS	1.00		init	Rs'	dmh 1x30	36
aspirin 400ppm	Reddy Ra. 93	28	36	17	36	0.60	*	1.66	40	post	Rf'	aom 2x15	52
aspirin 200ppm	Reddy Ra. 93	28-	36-	19	36	0.68	*	1.47	32	post	Rf'	aom 2x15	52
aspirin 5 mg/kg/d	Davis 94	8	8	7	7	1.00	NS	1.00		both	Rw'	dmh 18x30	18
aspirin 30 mg/kg/d	Davis 94	8-	8-	4	8	0.50	MS	2.00	50	both	Rw'	dmh 18x30	18
aspirin 60 mg/kg/d	Davis 94	8-	8-	2	8	0.25	*	4.00	75	both	Rw'	dmh 18x30	18
aspirin 250 ppm wk2-36	Pence 95	40	47	35	43	0.95	NS	1.05	5	post	Rf'	aom 2x12	51
aspirin 250 ppm wk36-51	Pence 95	40-	47-	31	32	1.14	NS	0.88	-14	post	Rf'	aom 2x12	51
aspirin 500 ppm	Barnes 99	15	32	10	32	0.66	NS	1.52	34	init	Rs'	dmh 8x12	30
aspirin 500 ppm	Barnes 99	15-	32-	15	32	1.00	NS	1.00		post	Rs'	dmh 8x12	30
aspirin 500 ppm	Barnes 99	15-	32-	5	32	0.34	*	2.94	66	both	Rs'	dmh 8x12	30
aspirin 400 ppm	Li Schut 99	10	27	9	27	0.90	NS	1.11	10	both	Rf'	aom 2x15	38
aspirin 200 ppm	Li Schut 99	22	31	24	34	0.99	NS	1.01	1	both	Rf'	aom 2x15	44
aspirin 600 ppm	Li Schut 99	22-	31-	21	33	0.90	NS	1.12	10	both	Rf'	aom 2x15	44
aspirin 1800 ppm	Li Schut 99	22-	31-	15	29	0.73	NS	1.37	27	both	Rf'	aom 2x15	44
aspirin 200 ppm wk11-43	Li Schut 99	22-	31-	22	28	1.11	NS	0.90	-11	post	Rf'	aom 2x15	44
aspirin 600 ppm wk11-43	Li Schut 99	22-	31-	20	27	1.04	NS	0.96	-4	post	Rf'	aom 2x15	44
aspirin 1800 ppm wk11-43	Li Schut 99	22-	31-	16	30	0.75	NS	1.33	25	post	Rf'	aom 2x15	44
aspirin 300ppm	Molck 02	9	16	6	16	0.67	NS	1.50	33	both	Rf'	aom 2x15	18
aspirin 300ppm (vit.D3 diet)	Molck 02	9	16	6	16	0.67	NS	1.50	33	both	Rf'	aom 2x15	18
aspirin 30 mg/kg/d	Miliaras 04	15	15	7	14	0.50	*	2.00	50	both	Rw"	dmh 20x20	32
aspirin 10 mg/kg/d	Miliaras 04	15-	15-	15	15	1.00	NS	1.00		both	Rw"	dmh 20x20	32
	Refs.not included					RR	p	95%CI low	95%CI high
Total no. rats / Meta-RR		167	252	313	559	0.845	0.006	0.75	0.95

Corpet D.E. & Pierre F. 2005, Eur.J.Cancer - http://www.inra.fr/reseau-nacre/sci-memb/corpet/indexan.html

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