Colon ACF promotion in rats. Table: http://corpet.net/min Data ranked by PromotionPotency Corpet D.E. 2008 Line # In CONSTRUCTION Promoting agent or diet, and dose Cate gory Author, year (click name for abstract)-> Potency/ACF = times-fold increase Percent increase Protocol ACF No, con. ACF No, treat. Crypt /ACF con. Crypt /ACF treat Potency/ crypt per ACF Potency/ Aberrant Crypts Ro- dent Carcinogen N x dose Treat. weeks Line # P01 high-fat cafeteria (pate, bacon, choc.) fat Delage 05->15856452 9.06 806 both 21 192 1.10 9.97 Rw' dmh 1x15 -4+4 P01 P02 ethanol 5% in liquid diet other Hayashi 07->17331170 7.33 633 both 1 4 Rw' dmh 16x20 0+39 P02 P03 DSS 1.5% 2x1wk dss Nishikawa 05->15635146 5.73 473 post 12 69 1.17 1.62 1.38 7.93 Mc' MeIQx 300ppmx12wks +1+2 P03 P04 deoxycholic acid 0.25% /AKR/J mice bile Flynn 07->17091474 5.52 452 post 6 34 Ma' aom 6x10 +1+4? P04 P05 deoxycholic acid 0.25% /AKR/J mice bile Flynn 05 5.51 451 post 6.2 34 Ma aom +1+ P05 P06 calcium 0.32 vs 0.04% //MNU LFdiet miner Weisburger 94->7889859 3.20 220 both 129 413 2.61 2.72 1.04 3.33 Rf' mnu 4x2mg -1+8 P06 P07 exercise (swim to exhaustion) other Demarzo 04->15500946 2.92 192 init 3.7 11 Rw' dmh 1x50 +0 P07 P08 fasted-refed (4d fast - 1d refed) other Caderni 99->10693167 2.67 167 init 4.5 12 2.70 3.19 1.18 3.15 Rf' aom 1x7.5 -5d-1d P08 P09 Orlistat 200ppm+ hi.fat 10% cotton oil other Garcia 05->16377080 2.67 167 ? 6.2 17 Rw dmh 2x25 ? P09 P10 gastrin-KO lean vs wild mice insul Cowey 05->15864814 2.60 160 both 2.3 5.9 M' aom 3x8 -24+2 P10 P11 deoxycholic acid 0.25% /AKR/J mice bile Flynn 05 2.51 151 init 6.2 16 Ma aom -1+1 P11 P12 fish oil vs corn oil 7% /IL10 KO mice fat Hegazi 06->16500554 2.29 129 init 1.4 3.2 91 209 2.29 5.23 Mko' none +0+12 P12 P13 high-fat corn oil 23.5% vs.5% fat Kohno 00->10948340 2.16 116 both 22 47 1.20 1.68 1.40 3.02 Rf' aom 3x15 -1+4 P13 P14 high-fat fish oil 23.5% vs.5% fat Kohno 00->10948340 2.02 102 both 17 34 1.47 1.50 1.02 2.07 Rf' aom 3x15 -1+4 P14 P15 calcium low- 0.1% vs 0.5% miner Thiagaraj. 98->9848506 1.90 90 post 70 133 4.31 4.35 1.01 1.92 Rf' aom 2x15 +1+13 P15 P16 Lactobacillus casei 2.5 10E6 fibact+ Bolognani 01->11876494 1.76 76 post 75 131 Rs' dmh 1x60 -1+12 P16 P17 methionine L- 1% prot Duranton 99->10190567 1.75 75 post 20 35 Rw' aom 2x15 +0+12 P17 P18 cholic acid 0.5% * MDF bile Femia 04->14604897 1.74 74 post 6.1 11 6.62 11.2 1.68 2.93 Rf' aom 2x15 +1+10 P18 P19 oxothiazolidine carboxylate 0.2% other Wargovich 00->10837003 1.72 72 init 79 136 Rf' aom 2x15 -1+5 P19 P20 Orlistat 200ppm other Garcia 05->16377080 1.71 71 ? 6.2 11 Rw dmh 2x25 ? P20 P21 high-fat 20% vs 5% lipid mix fat Rao Hirose01->11280748 1.67 67 both 109 182 Rf' aom 2x15 -2+8 P21 P22 calcium 0.32 vs 0.04% //MNU HFdiet miner Weisburger 94->7889859 1.65 65 both 234 387 2.82 3.03 1.08 1.78 Rf' mnu 4x2mg -1+8 P22 P23 sitosterol (beta) 0.6% other Wargovich 96->9162301 1.65 65 init 83 137 Rf' aom 2x15 -1+4 P23 P24 arsenite 50 vs 0.5 ęg/g other Uthus 05->15772437 1.63 63 both 54 87 2.64 2.53 0.96 1.56 Rf' dmh 2x25 -3+8 P24 P25 sulfasalazine 0.04% other Wargovich 96->9162301 1.62 62 init 78 126 Rf' aom 2x15 -1+4 P25 P26 lutein 2000ppm phyto Raju 05->15499611 1.59 59 both 86 137 2.60 2.55 0.98 1.56 Rf' aom 2x15 -2+7 P26 P27 high-fat safflower oil 25% vs.5% fat Delage 04->15203375 1.57 57 both 21 33 2.92 3.46 1.18 1.86 Rf' dmh 1x15 -4+17 P27 P28 gastrin-KO obese vs KO lean mice insul Cowey 05->15864814 1.55 55 both 5.9 9.1 M' aom 3x8 -24+2 P28 P29 deoxycholic acid 0.3% //dmh+dss irrit Onose 06->15876482 1.50 50 post 21 31 Rf' dmh 3x40 +2+19 P29 P30 catechin +/- 0.5% phyto Wargovich 96->9162301 1.50 50 init 78 117 Rf' aom 2x15 -1+4 P30 P31 benzyl isothiocyanate 0.1% phyto Wargovich 96->9162301 1.49 49 init 83 124 Rf' aom 2x15 -1+4 P31 P32 B-carotene 2000ppm phyto Raju 05->15499611 1.44 44 both 86 124 2.60 2.60 1.00 1.44 Rf' aom 2x15 -2+7 P32 P33 dehydroepiandosterone 0.2% other Wargovich 96->9162301 1.43 43 init 81 116 Rf' aom 2x15 -1+4 P33 P34 blood sausage (boudin) 60% hem Pierre 04->15465771 1.43 43 post 72 103 2.67 2.94 1.10 1.57 Rf'' aom 1x20 +1+14 P34 P35 propyl gallate 0.16% other Wargovich 96->9162301 1.43 43 init 77 110 Rf' aom 2x15 -1+4 P35 P36 hemoglobin 5% hem Bruce 93 1.40 40 post 164 229 4.24 4.88 1.15 1.61 Rf aom 1x20 +1+14 P36 P37 meat beef- 60% hem Pierre 04->15465771 1.39 39 post 72 100 2.67 2.79 1.04 1.45 Rf'' aom 1x20 +1+14 P37 P38 high-fat corn oil 23% vs 5% * MDF * fat Femia 05 1.38 38 post 4.1 5.7 9.75 8.85 0.91 1.25 Rf' dmh 2x150 +1+14 P38 P39 tea black- extract 1% phyto Wargovich 00->10837003 1.37 37 init 73 100 Rf' aom 2x15 -1+5 P39 P40 DSS 1% 1wk dss Tanaka 01->11289109 1.37 37 init 84 115 2.00 2.40 1.20 1.64 Rf' aom 2x20 -2-1 P40 P41 fecapentaene12 114ng/d irrit Zarkovic 93->8330337 1.34 34 post 10 13 Rf'' mnu 9x20 +5+29 P41 P42 soy 23% vs low isoflavone soy phyto Davies 99->10357769 1.34 34 both 125 167 Rf' dmh 2x25 -3+8 P42 P43 meclofenamate Na 40mg/kg other Wargovich 00->10837003 1.33 33 init 103 137 Rf' aom 2x15 -1+5 P43 P44 hemin 1.5 micromol/g hem Pierre 03->12896910 1.32 32 post 125 165 2.58 11.4 4.42 5.84 Rf'' aom 1x20 +1+14 P44 P45 hemoglobin 0.36micromol/g hem Pierre 03->12896910 1.30 30 post 125 162 2.58 3.18 1.23 1.60 Rf'' aom 1x20 +1+14 P45 P46 carbenoxolone 0.1% other Wargovich 00->10837003 1.29 29 post 182 235 Rf' aom 2x15 +4+8 P46 P47 carbenoxolone 0.1% other Wargovich 00->10837003 1.27 27 init 240 304 Rf' aom 2x15 -1+5 P47 P48 cooked casein 20% prot Zhang 92->1608054 1.23 23 post 116 143 2.51 3.63 1.45 1.78 Rf'' aom 1x20 +1+14 P48 P49 high-fat 22% vs 7% 15BT fat Morotomi 97->8970188 1.22 22 init 114 139 1.90 2.17 1.14 1.39 Rf' aom 2x15 -1+6 P49 P50 tea green- extract 1% phyto Wargovich 00->10837003 1.20 20 init 120 144 Rf' aom 2x15 -1+5 P50 P51 fasted-refed 5x(4d fast - 7d refed) other Caderni 02->11872640 1.12 12 post 40 45 2.40 4.30 1.79 2.02 Rf' aom 1x20 +1+10 P51 P52 high-fat 37% vs 5% 32BT fat Koohesta. 97->9383787 1.09 9 post 112 122 2.49 3.57 1.43 1.56 Rf' aom 1x20 +1+14 P52 P53 insulin injections 20 U/kg/d x72d insul Corpet 97->9101563 1.00 0 post 259 260 2.49 2.76 1.11 1.11 Rf'' aom 1x20 +1+14 P53 P54 high-fat corn oil 23% vs 5% fat Femia 05 0.95 -5 post 161 154 3.42 3.13 0.91 0.87 Rf' dmh 2x150 +1+14 P54 P55 high-fat vs lowF /calor.restr-20% fat Lasko 95->7894324 0.94 -6 post 170 160 3.02 3.50 1.16 1.09 Rf' aom 2x15 +11+23 P55 P56 cholic acid 0.5% bile Femia 04->14604897 0.87 -13 post 210 182 2.96 2.56 0.86 0.75 Rf' aom 2x15 +1+10 P56 P57 cooked casein+fat 20+20% prot Corpet 90->2208161 0.79 -21 post 53 42 6.02 8.67 1.44 1.14 Rf'' aom 1x30 +1+14 P57 P58 bisacodyl 43mg/kg irrit Borrelli 01->11693267 0.78 -22 both 135 105 3.00 4.44 1.48 1.15 Rw' aom 2x15 +0+13 P58 P59 Senna extract 100mg/kg irrit Mascolo 99->10573366 0.75 -25 both 131 98 2.50 4.20 1.68 1.26 Rw' aom 2x15 +0+13 P59 P60 carrageenan 2.5% in water irrit Corpet 97->9103253 0.64 -36 post 86 55 2.98 3.44 1.15 0.74 Rf'' aom 1x20 +1+14 P60 P61 carrageenan 2.5%water irrit Tache 00->11142093 0.64 -36 post 86 55 2.98 3.44 1.15 0.74 Rf'' aom 1x20 +1+14 P61 P62 cooked casein 12.5% prot Corpet Cas95->8610044 0.63 -37 post 128 81 3.20 4.10 1.28 0.81 Rf' aom 1x20 +1+14 P62 P63 cholic acid 0.2% bile Magnuson 93->8422645 0.45 -55 both 165 74 2.90 3.63 1.25 0.56 Rs' aom 2x20 +0+8 P63