Colon cancer chemoprevention in rats. Go to http://corpet.net/min Data ranked by potency Corpet D.E. & Tache 2002, Nutrition and Cancer, updated 2008 Numb. TREATMENT //carcinogen (if not AOM) and /mice (if not rats) Category Author, year (click name for abstract)-> Potency on tumor incidence Tumor percent inhibition Cancer percent inhibition Potency on tumor multiplic. Protocol blinded scoring Ro- dents carcinogen N x dose weeks Tum. in Contrl No. of Contrl Rats Tum. in treatd No. of Treated Rats Potency on tumor incidence Carcin. in ctrl Contrl rats Carcin. in treatd Treated rats Cancer percent inhibition Multiplic. in contrl Multiplic. in treatd Potency on tumor multiplic. Agent (3 lett.) or comment T001 DFMO 0.3% /N+ Tao Kramer 02->12189186 52.1 100 post Rf' aom 3x15 36 21 29 0.5 36 52.14 1.45 0.00 50.0 dfm T002 celecoxib 0.1% NSAI+ Reddy Pat. 05->16140976 40.0 100 43.0 post Rf' aom 2x15 25 20 24 0.5 24 40.00 0.90 0.02 43.0 cel T003 celecoxib 250ppm+fish oil 10% combi+ Reddy Pat. 05->16140976 20.0 95 22.1 post Rf' aom 2x15 25 20 24 1 24 20.00 0.90 0.04 22.1 cel T004 celecoxib 0.15% NSAI Kawamori 98->9458081 15.4 93 96 32 both blind Rf' aom 2x15 50 29 34 2 36 15.35 76 % 3 % 96 1.91 0.06 31.8 cel T005 Bifidobact. longum 0.5% //IQ ! fibact Reddy Riv. 93->8358717 14.0 93 both Rf' iq 125ppm 58 7 30 0.5 30 14.00 0.43 0.00 bif T006 BB protease inh. purif. 0.1% ! phyto+ Kennedy 02->12588698 10.7 91 both Rs' dmh 6x13 27 5 28 1 60 10.71 bbi T007 BB protease inh. 0.5% /mice ! phyto StClair 90->2297699 10.4 90 87 11 both Md' dmh 20x 7 32 7 62 1 92 10.39 5 62 1 92 87 0.11 0.01 11.0 bbi T008 DFMO 0.2%+pirox. 200ppm combi Rao Toku. 91->1831401 9.00 89 88 16 both Rf' aom 2x15 52 27 36 3 36 9.00 72 % 8.3 % 88 1.28 0.08 16.0 dfm T009 PEG 8000 5% PEG Corpet 00->10866305 8.56 88 100 10 post blind Rf' aom 2x20 24 22 27 2 21 8.56 6 27 0 21 100 3.10 0.30 10.3 peg T010 Low Fat 5% vs 20%BT //DMBA fat+ Mori Imaid. 01->11676852 8.00 88 83 both Rf' dmba 10x50 60 8 20 1 20 8.00 6 20 1 20 83 LF T011 starch resistant RS3 10% ! fibact+ BauerMarin. 06->16597648 8.00 88 85 6.0 both Rs' dmh 20x20 22 6 12 0.5 8 8.00 5 12 0.5 8 85 0.60 0.10 6.0 RS T012 MMTS 100ppm phyto Kawamori 95->7664279 7.93 87 100 post Rf' aom 3x15 36 17 30 2 28 7.93 13 30 0 28 100 mmt T013 BB protease inh. 0.5% /mice ! phyto Weed 85->4040444 7.30 86 12 both Md' dmh 20x 7 32 7 46 0.5 24 7.30 0.24 0.00 bbi T014 folate 8ppm ! vitB Kim Salom. 96->9014775 7.00 86 11 both Rs' dmh 15x44 15 7 10 1 10 7.00 1.10 0.10 11.0 fol T015 PEG 8000 5% PEG Parnaud 99->10537289 7.00 86 100 21 post blind Rf' aom 1x20 12 14 20 1 10 7.00 9 20 0 10 100 2.10 0.10 21.0 peg T016 piroxicam 200ppm NSAI Li Kramer 99->10660105 6.67 85 63 3.3 post Rf' aom 2x15 47 100 % 15 % 6.67 42 % 15.4 % 63 0.50 0.15 3.3 pir T017 PEG 3350 + celecox. 5+0.15% combi+ Do Barnard 05->16047477 6.40 84 post Rf aom 3x20 16 8 10 1 8 6.40 peg T018 piroxicam 100ppm NSAI+ Zhang 02->12036908 6.17 84 5.5 both Mc dmh 10x20 35 11 33 2 37 6.17 0.33 0.06 5.5 pir T019 curcumin BDMC-A 80mg/kg ! phyto+ Devasena 03->12543061 6.00 83 both Rw' dmh 15x20 30 6 6 1 6 6.00 cur T020 sphingomyelin 0.05% fat+ Lemonnier 03->14592456 5.83 83 post Mf'' dmh 6x30 51 14 60 2 50 5.83 sph T021 obacunone 500ppm phyto Tanaka M. 01->11159759 5.76 83 83 6.5 post Rf' aom 2x20 29 18 25 2 16 5.76 18 25 2 16 83 0.84 0.13 6.5 oba T022 pectin 15% vs cellulose 5% fibact Watanabe 79->286824 5.70 82 both Rf' aom 57 % 10 % 5.70 pec T023 lovastatin + celecox. 200+300ppm combi+ Swamy 06 5.56 82 82 8.3 post Rf' aom 2x15 48 5.56 100 18 82 1.00 0.12 8.3 lov T024 DFMO 0.1%+aspir. 0.06% combi Li Schut 99->10190557 5.34 81 38 6.0 both Rf' aom 2x15 44 71 % 13.3 % 5.34 16.1 % 10 % 38 1.50 0.25 6.0 dfm T025 Mg(OH)2 500ppm miner Mori Morish. 93->8304923 5.31 81 77 7.5 post Rf' mam 3x25 32 17 32 3 30 5.31 14 32 3 30 77 0.75 0.10 7.5 mgo T026 copper 8ppm vs 0.2ppm ! miner diSilvestro 92->1528914 5.00 80 3.2 both Rs' dmh 12x20 25 5 11 1 11 5.00 0.64 0.20 3.2 cop T027 glucarate calcium 0.1mol/kg ! phyto Dwivedi 89->2752528 5.00 80 post Rf'' aom 3x15 32 5 18 1 18 5.00 glu T028 Lactobac. salivarius 10E9/d /mice ! fibact+ O'Mahony 01->11472326 5.00 80 ? blind Mc IL10-/- mice 16 5 10 1 10 5.00 lac T029 nobiletin 100ppm (citrus) //+dss ! phyto+ Miyamoto 08->18375960 5.00 80 88 21.0 post Mi' aom 10+dss 20 5 10 1 10 5.00 4 10 0.5 10 88 2.10 0.10 21.0 nob T030 vit. B6 35 ppm vs 7 ppm /mice ! vitB+ Komatsu 01->11481418 5.00 80 100 both Mi' aom 10x5 22 5 34 1 34 5.00 3 34 0 34 100 vB6 T031 tryptanthrin 50mg/kg phyto+ KoyaMiyata 01->11848486 4.90 80 100 both Rf'' aom 10x7.5 30 8 31 1 19 4.90 7 31 0 19 100 try T032 tetracycline 10mg/d meat diet fibact Goldin 81->6944555 4.84 79 4.8 both Rf' dmh 20x20 21 15 31 3 30 4.84 1.10 0.23 4.8 tet T033 butylhydroxyanisol .6% /mice other Reddy Mae. 83->6581364 4.79 79 9.4 init Mf'' mam 4x15 38 14 57 2 39 4.79 0.47 0.05 9.4 bha T034 hesperidin 0.1% phyto Tanaka M. 97->9163681 4.71 79 79 5.9 post Rf' aom 3x15 28 12 17 3 20 4.71 12 17 3 20 79 0.88 0.15 5.9 hes T035 CP-31398 + celecox. 300+150ppm combi+ Rao-Swamy 06 4.55 78 9.1 both Rf' aom 2x15 48 100 22 4.55 1.00 0.11 9.1 cel T036 DFMO 0.2% /N Rao Toku. 91->1831401 4.52 78 77 5.8 both Rf' aom 2x15 52 75 % 16.6 % 4.52 72.2 % 16.6 % 77 1.28 0.22 5.8 dfm T037 germfree vs normal flora fibact Reddy Nar. 75->162868 4.48 78 91 11 both Rf' dmh 20x20 34 14 15 5 24 4.48 14 15 2 24 91 2.10 0.20 10.5 gf T038 celecoxib 0.15% NSAI Reddy Hir. 00->10667579 4.47 78 77 6.1 both Rf' aom 2x15 52 76 % 17 % 4.47 74 % 17 % 77 1.35 0.22 6.1 cel T039 bran rye 30% vs 9% SolkaFlok phyto+ Davies 99->10357769 4.36 77 8.0 both Rf' aom 2x15 31 8 11 3 18 4.36 1.36 0.17 8.0 bra T040 PEG 8000 5% peg+ Roy Kunte 06->16928827 4.25 76 post Rf' aom 2x20 30 17 25 4 25 4.25 peg T041 PEG 8000 50ppm PEG+ Wali-Stoib. 02 4.25 76 post Rf' aom 2x20 36 17 25 4 25 4.25 peg T042 quercetin 2% /mice phyto Deschner 91->2070483 4.25 76 6.4 both Mf aom 3x10 48 8 32 2 34 4.25 0.56 0.09 6.4 que T043 meat beef vs.milk prot. /mice other Nutter 83->6578376 4.25 76 6.3 both Mb' dmh 11x20 49 61 91 15 95 4.25 1.88 0.30 6.3 mea T044 bran wheat +caloric.rest.-10% combi Kritchevs. 97->9103252 4.17 76 post Rf' dmh 5x30 48 16 23 4 24 4.17 bra T045 soy protein 20% vs casein other Hakkak 01->11295283 4.10 76 68 both Rs aom 2x15 40 21 42 5 41 4.10 13 42 4 41 68 soy T046 CCK-B/gastrin antag. 15mg/kg other+ Fontana 02->11961341 4.07 75 2.4 init Md' dmh 5x20 38 19 49 6 63 4.07 0.88 0.37 2.4 cck T047 aspirin 60mg/kg/d NSAI Davis 94->7980214 4.00 75 8.3 both Rw' dmh 18x30 18 8 8 2 8 4.00 3.10 0.38 8.3 asp T048 BB protease inh. conc. 0.1% phyto+ Kennedy 02->12588698 4.00 75 both Rs' dmh 6x13 27 12 21 3 21 4.00 bbi T049 Bifidobact. longum 1% /mice fibact+ Ohno 00->11109558 4.00 75 10.3 ? M dmh 20x20 24 9 9 2 8 4.00 4.10 0.40 10.3 bif T050 columbin 100ppm phyto+ Kohno 02->12065087 4.00 75 82 4.7 init Rf' aom 3x15 30 12 20 3 20 4.00 11 20 2 20 82 0.70 0.15 4.7 col T051 ursodeoxycholic 0.4% //dss /mice other+ Loddenkemp. 06->16385573 3.75 73 95 2.8 both Mc'' dss 105x.7% 36 15 24 4 20 3.75 11 24 0.5 20 95 1.25 0.45 2.8 urs High Iron diet T052 indole3carbinol 0.1% //IQ !! phyto+ Xu Orner 01->11181453 3.64 73 post Rf' iq 5w300ppm 51 2 22 0.5 20 3.64 1.00 0.00 i3c T053 olive oil 23.5% vs corn oil fat Reddy Mae. 84->6583457 3.54 72 post Rf' aom 2x15 34 46 % 13 % 3.54 oli T054 acetoxychavicol 500ppm phyto Tanaka K. 97->9369929 3.53 72 93 2.8 post Rf' aom 3x15 34 12 17 4 20 3.53 12 17 1 20 93 0.83 0.30 2.8 ace T055 resveratrol 8mg/kg phyto+ Sengottuvel. 06->16338953 3.50 71 4.8 both Rw' dmh 15x20 30 14 16 4 16 3.50 1.19 0.25 4.8 res dubious T056 piroxicam 400ppm NSAI Rao Toku. 91->1831401 3.38 70 69 3.4 both Rf' aom 2x15 52 75 % 22.2 % 3.38 72 % 22 % 69 1.28 0.38 3.4 pir T057 gefitinib EGFR inhib. 10m/kg other+ Dougherty 08->18413814 3.38 70 85 3.3 post blind Rf' aom 2x20 44 27 38 8 37 3.38 20 38 3 37 85 1.16 0.35 3.3 gef T058 NO-indomethacin 80ppm /N+ Rao Reddy 06->16818512 3.38 70 65 4.2 both Rf' aom 2x15 46 27 36 8 34 3.38 12 36 4 34 65 1.58 0.38 4.2 NOi T059 Low Risk vs high risk diet other Rao Goett. 88->3353310 3.36 70 86 both Rf'' aom 3x15 36 42 % 12.5 % 3.36 29.2 % 4.2 % 86 LR T060 caloric restriction -30% other Kritchevs. 97->9103252 3.34 70 post Rf' dmh 5x30 48 16 23 5 24 3.34 CR T061 fish oil 10% vs mixed lipids fat+ Reddy Pat. 05->8358717 3.33 70 3.5 post Rf' aom 2x15 25 20 24 6 24 3.33 0.90 0.25 3.5 fis T062 phytate 2% in water phyto Pretlow 92->1394832 3.33 70 70 2.7 post Rf' aom 1x30 36 10 12 3 12 3.33 10 12 3 12 70 1.60 0.60 2.7 phy T063 vit. D3-6Fl RO24 2.5nmol/kg vitAD Wali Bisso. 95->7606726 3.33 70 3.3 init Rf' aom 2x15 34 10 20 3 20 3.33 0.50 0.15 3.3 vD3 T064 sulindac sulfone 0.12% NSAI Reddy Kaw. 99->10416599 3.27 69 68 5.9 both Rf' aom 2x15 51 85 % 26 % 3.27 82 % 26 % 68 2.00 0.34 5.9 sul T065 purple corn color 5% //PhIP phyto Hagirawa 01->11485824 3.17 68 91 9.0 both Rf' dmh 80+PhIP 36 19 20 6 20 3.17 11 20 1 20 91 2.70 0.30 9.0 pur T066 Low Fat 5% vs. 20% beef fat fat+ Reddy Wa. 77->908050 3.14 68 2.1 both Rf' mnu 2x2.5/r 35 22 30 7 30 3.14 2.45 1.14 2.1 LF T067 DHA 0.4ml/d vs linoleic acid fat+ Toriyama 01->11714441 3.13 68 56 5.8 post Rf' dmh 6x60 34 15 16 3 10 3.13 11 16 3 10 56 2.32 0.40 5.8 dha T068 silymarin 500ppm phyto+ Kohno 02->12216075 3.09 68 81 4.8 init Rf' aom 3x15 33 13 20 4 19 3.09 11 20 2 19 81 1.00 0.21 4.8 sil T069 aspirin 500 ppm NSAI+ Barnes 99->10206272 3.00 67 both Rs' dmh 8x12 30 15 32 5 32 3.00 asp T070 fish oil +CLA 9+1% vs beef tallow fat+ Kim Park 03->12921888 3.00 67 4.6 both Rs' dmh 12x15 30 12 30 4 30 3.00 0.60 0.13 4.6 fis T071 fish oil 10% ! fat+ Fujise 07->17194898 3.00 67 4.6 both Rs' aom 2x15 44 6 6 2 6 3.00 2.30 0.50 4.6 fis T072 nimesulide 400ppm //+dss NSAI+ Onose 06->15876482 3.00 67 88 10.3 post Rf' dmh 120+dss 20 9 10 3 10.00 3.00 8 10.00 1.00 10.00 88 4.10 0.40 10.3 nim T073 sericin (silk prot.) 3% other+ Zhaorigetu 01->11758907 3.00 67 100 4.2 both Mi' dmh 10x10 18 15 40 5 40 3.00 3 40 0 40 100 0.55 0.13 4.2 ser T074 yugao 10% /mice fibact Furukawa 95->7889483 3.00 67 67 6.0 both Mi dmh 10x10 35 9 18 3 18 3.00 9 18 3 18 67 1.20 0.20 6.0 yug T075 sulindac sulfone 0.2% NSAI Piazza 97->9230200 2.96 66 81 5.0 post Rf' aom 2x15 31 80 % 27 % 2.96 53 % 10 % 81 2.00 0.40 5.0 sul T076 aspirin 10ppm NSAI Craven 92->1315625 2.94 66 66 2.9 init Rs' dmh 1x30 36 50 % 17 % 2.94 50 % 17 % 66 0.50 0.17 2.9 asp T077 protocatechuic acid 0.1% phyto Tanaka K. 93->8358716 2.88 65 71 4.3 post Rf' aom 3x15 28 15 20 6 23 2.88 15 20 5 23 71 1.30 0.30 4.3 pro T078 ursodeoxycholic acid 0.4% other Earnest 94->7923119 2.88 65 100 2.9 both Rf' aom 2x15 28 10 20 4 23 2.88 3 20 0 23 100 0.50 0.17 2.9 urs T079 lycopene 400ppm 14%fat diet phyto+ MartinezF. 04 2.86 65 4.0 both Rf' aom 2x16 31 100 % 35 % 2.86 4.40 1.10 4.0 lyc T080 flaxseed 15% phyto+ Bommareddy 06->16898866 2.83 65 4.3 both Rf' aom 3x15 36 19 23 7 24 2.83 1.30 0.30 4.3 fla T081 flaxseed vs corn meal 15% phyto+ Reddy-Aras. 05 2.81 64 6.5 both Rf' aom 3x15 35 82.6 % 29.4 % 2.81 1.30 0.20 6.5 fla T082 cellulose 20% vs 3% fibact Madar-Weis. 96 2.76 64 86 2.6 both Rs' dmh 5x20 24 23 25 6 18 2.76 40 % 5.6 % 86 1.00 0.38 2.6 cel T083 pravastatin 10ppm /mice other Narisawa 96->9111762 2.76 64 1.3 both Mi dmh 10x20 35 16 29 6 30 2.76 0.80 0.60 1.3 pra T084 fish oil 23.5% vs corn oil fat Reddy Mar. 86->3708570 2.75 64 73 5.2 post Rf' aom 2x15 34 22 24 8 24 2.75 15 24 4 24 73 1.96 0.38 5.2 fis T085 psyllium 15% vs cellulose 5% fibact Wilpart 87->3039470 2.75 64 1.5 both Rw' dmh 15x30 45 11 32 4 32 2.75 1.50 1.00 1.5 psy T086 piroxicam 400 ppm NSAI Reddy Tok. 92->1600605 2.75 64 67 2.7 both Rf' aom 2x15 54 61 % 22.2 % 2.75 58.3 % 19.4 % 67 1.03 0.38 2.7 pir T087 gluconate Na 5% fibact+ Kameue 04->15051851 2.67 63 60 5.6 both Rf' aom 45+dca 33 8 8 3 8 2.67 5 8 2 8 60 2.80 0.50 5.6 glu T088 Lactobac. acidophilus 1% fibact McIntosh 99->10693169 2.67 63 3.3 both Rs' dmh 4x20 28 40 % 15 % 2.67 0.50 0.15 3.3 lac T089 rotenone 500ppm phyto+ Yoshitani 01->11604990 2.67 63 69 1.5 post Rf' aom 3x20 37 10 15 4 16 2.67 9 15 3 16 69 1.07 0.71 1.5 rot T090 rice germ 2.5% phyto Kawabata 99->10545413 2.63 62 62 1.6 init Rf' aom 3x15 32 15 20 4 14 2.63 15 20 4 14 62 0.90 0.57 1.6 ric T091 tomato juice (lycop) //MNU phyto Narisawa 98->9849577 2.60 62 62 2.0 both Rf'' mnu ir3x2 35 13 24 5 24 2.60 13 24 5 24 62 0.60 0.30 2.0 tom T092 Low Fat 5% vs. 20% beef fat fat+ Reddy Wa. 77->908050 2.57 61 1.2 both Rf' dmh 1x150 35 18 30 7 30 2.57 1.33 1.14 1.2 LF T093 bran wheat 10%+wb.oil 2% fibact Reddy Hir. 00->10987288 2.57 61 61 3.2 both Rf' aom 2x15 50 77 % 30 % 2.57 77 % 30 % 61 1.27 0.40 3.2 bra T094 KYN-54 200ppm vitAD Kawamori 95->7728957 2.57 61 68 1.4 post Rf' aom 3x15 32 11 30 4 28 2.57 10 30 3 28 68 0.40 0.29 1.4 kyn T095 estrone 0.63mg/d Soy diet /mice other+ Guo Brown. 04->14704314 2.54 61 1.8 both Mw'' aom 6x15 50 31 30 11 27 2.54 0.85 0.48 1.8 est T096 piroxicam 200ppm NSAI+ Tao 02->12189186 2.53 61 4.1 post Rf' aom 3x15 36 21 29 10 35 2.53 1.45 0.35 4.1 pir T097 inositol + IP6 phyto+ Vucenik 03->14608114 2.52 60 3.0 post M dmh ? 63 % 25 % 2.52 12.00 4.00 3.0 ino T098 diosgenin 0.1% phyto+ Malisetty 05 2.50 60 3.1 post Rf' aom 2x15 48 100 40 2.50 1.00 0.32 3.1 dio T099 quercetin 1% phyto+ Dihal 06->17056814 2.50 60 1.6 both Rf' aom 1x15 38 11 22 4 20 2.50 1.55 1.00 1.6 que Rutin no effect T100 nerolidol 0.5% other Wattenb. 91->1988176 2.48 60 2.1 post Rf' aom 6x15 22 82 % 33 % 2.48 1.50 0.70 2.1 ner T101 Lactobac. acidophil. vs.germ-free fibact+ Horie 99->10443953 2.46 59 both Mq dmh 10x15 33 14 19 6 20 2.46 lac T102 beans (Navy) 75% vs starch+cell phyto+ Hangen 02->12672642 2.43 59 60 2.2 both Rf' aom 2x15 32 17 28 7 28 2.43 10 28 4 28 60 2.20 1.00 2.2 bea T103 Kurozu rice vinegar extr. 0.1% drink phyto+ Shimoji 04->15489210 2.43 59 56 1.9 post Rf' aom 2x20 35 17 20 7 20 2.43 16 20 7 20 56 1.50 0.80 1.9 kur T104 putrescine inj. 150æmol/kg /N Tatsuta 91->2004855 2.40 58 2.5 both Rw' aom 10x7.4 40 16 20 6 18 2.40 1.00 0.40 2.5 put T105 allylcysteine 400ppm /mice phyto Sumiyoshi 90->2379172 2.38 58 83 3.6 both Mc dmh 10x20 25 19 30 8 30 2.38 6 30 1 30 83 0.97 0.27 3.6 all T106 curcumin 1.6% phyto+ Pereira 96->8681447 2.38 58 -200 2.4 both Rf' aom 1x30 45 19 36 8 36 2.38 2 36 6 36 -200 0.64 0.27 2.4 cur T107 pioglitazone PPARgam 200ppm other+ Osawa 03->12557142 2.33 57 3.0 both Mb'' aom 6x10 32 14 30 5 25 2.33 0.97 0.32 3.0 pio T108 glucarate KHd- 0.14mol/kg phyto Yoshimi 00->10601547 2.31 57 2.6 post Rf' aom 2x15 40 15 26 6 24 2.31 0.65 0.25 2.6 glu T109 E-aminocaproic 1g/l /mice other Corasanti 82->6805074 2.29 56 8.0 both Mi dmh 21x15 34 17 17 7 16 2.29 11.20 1.40 8.0 Eam T110 canthaxanthin 500ppm phyto Tanaka K. 95->8603470 2.27 56 67 3.3 post Rf' aom 3x15 34 17 30 7 28 2.27 13 30 4 28 67 0.83 0.25 3.3 can T111 apigenin 250ppm /mice phyto+ Au Li 06->16898869 2.26 56 post Mf'' aom 4x10 23 22 34 8 28 2.26 api No dose-effect T112 B-carotene 0.2% phyto+ Imaida 90->2245410 2.25 56 56 1.8 post Rf' dmh 3x40 52 9 20 3 15 2.25 9 20 3 15 56 0.70 0.40 1.8 Bca T113 cellulose 25% vs no fiber fibact Madar 93->8415134 2.25 56 4.4 both Rs' dmh 5x20 24 18 20 4 10 2.25 2.20 0.50 4.4 cel T114 menadione 9mg/kg/d /mice other Bi-Geng 93 2.25 56 7.0 both Mi dmh 20x20 24 9 13 4 13 2.25 2.10 0.30 7.0 men T115 pectin apple 20% vs cell.5% fibact Ohkami 95->7622415 2.24 55 65 3.5 both Rd' aom 10x7.4 30 83 % 37 % 2.24 83 % 29 % 65 1.60 0.46 3.5 pec T116 sulindac 320ppm NSAI Rao Rivens. 95->7882354 2.23 55 55 3.8 both Rf' aom 2x15 47 - 29 36 13 36 55 1.50 0.40 3.8 sul T117 FOS raftilose 15% vs. cornstarch fibact+ Jacobsen 06->17044771 2.20 55 70 4.1 both Rf' aom 2x15 32 22 30 10 30 2.20 10 30 3 30 70 1.35 0.33 4.1 fos promot ACF T118 sulindac 160ppm /mice NSAI+ Hu LeLeu 05->15849741 2.18 54 54.2 2.7 both Mc aom 3x20 23 8 22 4 24 2.18 6 22 3 24 54 0.80 0.30 2.7 sul T119 sphingomyelin 500ppm/mice ! fat Dillehay 94->8169652 2.18 54 2.3 post Mf dmh 6x20 26? 7 15 3 14 2.18 0.90 0.40 2.3 sph T120 CLN (Punica granat. oil) 0.1% fat+ Kohno 04 2.17 54 3.7 both Rf' aom 2x20 31 13 16 6 16 2.17 cln T121 selenocyanate pXSC 40ppm other Reddy Riv. 92->1394188 2.16 54 3.3 post Rf' aom 2x15 36 80 % 37 % 2.16 1.73 0.53 3.3 sel T122 molybdenum 200ppm in water miner+ Montenegro 02->12619566 2.13 53 both Rw' dmh 16x20 13 100 % 47 % 2.13 mol T123 calcium 0.32% vs 0.04% miner Wargovich 90->2397478 2.13 53 1.8 both Rf'' aom 8x8 32 68 % 32 % 2.13 1.10 0.60 1.8 cal T124 selenocyanate benzyl 50ppm other Nayini 91->1645468 2.12 53 52 3.0 init Rf' aom 2x15 48 100 % 47.2 % 2.12 80.6 % 38.9 % 52 1.72 0.58 3.0 sel T125 selenium 4ppm (NaSe) other Nayini 91->1645468 2.11 53 48 2.2 post Rf' aom 2x15 48 100 % 47.3 % 2.11 80.6 % 41.7 % 48 1.72 0.78 2.2 sel T126 beans dry 59% phyto Hughes 97->9405582 2.10 52 47 6.5 post Rf' aom 2x15 34 10 20 5 21 2.10 9 20 5 21 47 1.30 0.20 6.5 bea T127 vaccination p53 other Zusman 98->9891232 2.10 52 62 12 both Rs dmh 7x20 26 42 45 8 18 2.10 26 45 4 18 62 9.30 0.80 11.6 vac T128 phytate 1% phyto Ullah 90->2265472 2.09 52 2.3 both Rf' aom 6x? 38 17 29 14 50 2.09 0.68 0.30 2.3 phy T129 perilla oil 12% //MNU fat Narisawa 94->7908858 2.08 52 2.5 both Rf'' mnu ir6x2mg 35 20 30 8 25 2.08 1.00 0.40 2.5 per T130 paprika juice (capsant.) //MNU phyto Narisawa 00->10806419 2.08 52 2.3 both Rf'' mnu ir9x2mg 30 83 % 40 % 2.08 1.60 0.70 2.3 pap T131 eicosapentaenoic 4.7% fat Minoura 88->2842039 2.07 52 4.0 both Rd' aom 11x7.4 31 20 29 10 30 2.07 1.66 0.41 4.0 eic T132 amiloride 7.5ppm other Tatsuta 95->7728977 2.03 51 1.9 both Rw' aom 10x7.5 35 15 19 7 18 2.03 0.95 0.51 1.9 ami T133 tea green, polyphenols 0.1% phyto Yamane 91->1778755 2.03 51 2.5 post Rf' aom 10x7.4 15 17 22 8 21 2.03 1.50 0.60 2.5 tea T134 aspirin +DFMO 55+55mg/kg ! combi+ Raul 07->17549408 2.00 50 3.0 post Rf dmh 2x25 35 3 3 3 6 2.00 2.00 0.66 3.0 asp colonography T135 nimesulide 400ppm /mice NSAI Fukutake 98->9855006 2.00 50 50 5.1 both Mi' aom 6x10 30 14 28 10 40 50 1.79 0.35 5.1 nim T136 B-carotene 22 ppm vs 2 phyto+ Temple 87->3473257 1.98 49 90 2.0 both Ms'' dmh 7x28 31 23 31 12 32 1.98 32.3 % 3.1 % 90 2.52 1.25 2.0 Bca T137 auraptene 500ppm phyto Tanaka K. 98->9635577 1.98 49 66 2.0 post Rf' aom 3x15 34 16 27 6 20 1.98 16 27 4 20 66 0.60 0.30 2.0 aur T138 hesperidin 7mg/d mandarin phyto Tanaka K. 00->10962453 1.97 49 78 2.1 post Rf' aom 2x20 38 20 29 7 20 1.97 20 29 3 20 78 0.83 0.40 2.1 hes T139 selenocyanate pXSC 20ppm other Reddy Riv. 97->9086007 1.96 49 -70 2.9 post Rf' aom 2x15 38 53 % 27 % 1.96 10 % 17 % -70 0.87 0.30 2.9 sel T140 curcumin 0.25mM/kg //+dss /mice phyto+ Kim-Lee 06 1.94 49 1.5 post Mi' aom 10+dss 14 83.3 % 42.86 % 1.94 6.00 4.00 1.5 cur T141 NO-aspirin 0.3% /N+ Rao Reddy 06->16818512 1.93 48 42 3.8 both Rf' aom 2x15 46 27 36 14 36 1.93 12 36 7 36 42 1.58 0.42 3.8 NOa T142 Lactobac. acidoph. 1E10 fibact Goldin 80->6766509 1.93 48 48 both Rf' dmh 20x20 20 77 % 40 % 1.93 77 % 40 % 48 lac T143 bran wheat 12% vs oat bran fibact Zoran 97->9349850 1.89 47 both Rs' aom 2x15 36 17 33 9 33 1.89 bra T144 ursodeoxycholic 0.08%//MNU other Narisawa 98->9849578 1.89 47 2.5 post Rf'' mnu ir9x2mg 27 17 25 9 25 1.89 1.00 0.40 2.5 urs T145 whey protein 20% vs casein other Hakkak 01->11352868 1.89 47 32 both Rs aom 2x15 40 18 32 14 47 1.89 7 32 7 47 32 whe T146 PEMC caffeate 750ppm phyto Rao Des. 95->7757981 1.88 47 66 2.0 both Rf' aom 2x15 54 81 % 43 % 1.88 38 % 13 % 66 1.50 0.76 2.0 pem T147 ursodeoxycholic acid 0.4% other+ Wali 02->12433708 1.88 47 78 1.5 post Rf' aom 2x20 30 34 47 15 39 1.88 11 47 2 39 78 1.90 1.30 1.5 urs T148 celecoxib 0.25mM/kg //+dss /mic. NSAI+ Lee-Kim 05 1.88 47 3.7 post Mi' aom 10+dss 14 75 % 40 % 1.88 3.67 1.00 3.7 cel T149 flaxseed oil 15% vs corn oil fat+ Dwivedi 05->15749630 1.88 47 4.4 both Rf' aom 3x15 35 30 30 16 30 1.88 3.10 0.70 4.4 fla T150 anethole trithione 200ppm phyto Reddy Rao 93->8339252 1.86 46 46 2.7 both Rf' aom 2x15 52 78 % 42 % 1.86 78 % 42 % 46 1.70 0.64 2.7 ane T151 EP1 mutation KO prostagl.rec./mic. other+ Kawamori 05->15564292 1.86 46 53 2.3 both Mc aom 6x10 50 16 28 8 26 1.86 16 28 7 26 53 0.79 0.35 2.3 ep1 T152 ferulic acid 250ppm phyto+ Kawabata 00->10893437 1.86 46 62 2.1 init Rf' aom 3x15 34 13 22 7 22 1.86 13 22 5 22 62 0.68 0.32 2.1 fer T153 flaxseed oil 15% vs corn oil fat+ Natarajan 04 1.85 46 4.4 both Rf' aom 3x15 35 100 % 54 % 1.85 3.10 0.70 4.4 fla T154 wheat germ extr.ferment. 3g/kg phyto+ Zalatnai 01->11577004 1.85 46 1.8 both Rf' aom 3x15 30 39 47 13 29 1.85 2.30 1.30 1.8 whe T155 ibuprofen 400 ppm NSAI Reddy Tok. 92->1600605 1.83 45 43 2.0 both Rf' aom 2x15 54 61 % 33.3 % 1.83 58.3 % 33.3 % 43 1.03 0.52 2.0 ibu T156 Low Fat 5% vs 18%lard //MNG fat Sinkeldam 90->2153449 1.83 45 0 2.1 both Rw' mnng 5x6 33 73 % 40 % 1.83 10 % 10 % 0 3.00 1.40 2.1 LF T157 calcium 2% vs 0.5% miner Karkare 91->2007910 1.82 45 -229 1.8 post Rf' dmh 1x200 35 21 28 7 17 1.82 2 28 4 17 -229 2.28 1.28 1.8 cal T158 whey protein 21% vs meat other McIntosh 95->7722681 1.82 45 both Rs' dmh 3x15 29 53.7 % 29.5 % 1.82 whe T159 probiotic SCM-III LacBif 2ml/d !! fibact+ Marotta 03->14696432 1.80 44 2.2 both Rs' aom 10x15 20 18 20 10 20 1.80 2.20 1.00 2.2 pro T160 retinoic Am-55P 20ppm vitAD+ Orita 04->15200164 1.80 44 43 3.3 post Rs'' dmh 5x40+2D 37 9 18 5 18 1.80 7 18 4 18 43 1.11 0.33 3.4 ret T161 inulin 10% fibact+ Verghese 02->12221250 1.78 44 3.8 both Rf' aom 2x16 41 8 9 9 18 1.78 4.50 1.20 3.8 inu T162 mangiferin 200ppm phyto Yoshimi 01->11165750 1.77 44 1.2 post Rf' aom 3x15 40 12 22 8 26 1.77 0.59 0.50 1.2 man T163 bran wheat 15% vs.5%cell. //dmab fibact+ Reddy Mori 81->6268321 1.76 43 42 2.7 both Rf' dmab 20x50 40 43 94 13 50 1.76 13 94 4 50 42 0.75 0.28 2.7 bra T164 quinone HTHQ, antiox. 0.5% other+ Futakuchi 02->11872633 1.75 43 39 1.8 post Rf' dmh 4x40 32 15 20 9 21 1.75 14 20 9 21 39 1.29 0.71 1.8 qui T165 selenium 2.5ppm (NaSe) other Reddy Su. 88->3349457 1.75 43 90 2.6 post Rf' aom 2x15 34 21 27 12 27 1.75 10 27 1 27 90 1.62 0.63 2.6 sel T166 indomethacin i.r. 7.5mg/kg NSAI+ Kudo 80->7202921 1.74 43 1.7 post Rd' mam 6x20 30 87 % 50 % 1.74 3.30 2.00 1.7 ind T167 carbon fiber activated 1g/kg other Anisimov 99->10378770 1.73 42 2.4 both Rl'' dmh 5x21 26 20 21 11 20 1.73 2.60 1.10 2.4 car T168 bran wheat 15% vs 5%cell. fibact Watanabe 79->286824 1.73 42 both Rf aom ? 57 % 33 % 1.73 bra T169 wine extract (red) 50mg/kg phyto Caderni 00->11062155 1.73 42 -31 1.6 post blind Rf' aom 10x7.4 16 19 22 11 22 1.73 45 % 59 % -31 2.54 1.63 1.6 win T170 ursodiol-5-ASA 0.02% //MNU other+ Narisawa 02->11856477 1.72 42 42 1.9 post Rf'' mnu 9x20 30 24 29 12 25 1.72 24 29 12 25 42 1.30 0.70 1.9 urs T171 curcumin 0.2% phyto Rao Rivens. 95->7812955 1.72 42 47 2.3 both Rf' aom 2x15 52 81 % 47 % 1.72 38 % 20 % 47 1.50 0.66 2.3 cur T172 caloric restriction -30% other Holt Mokuol. 96->8710682 1.72 42 2.2 both Rf' aom 2x15 48 88.9 % 51.8 % 1.72 1.81 0.81 2.2 CR T173 Low Fat 5% vs 20% corn oil fat Holt Mokuol. 96->8710682 1.72 42 2.1 both Rf' aom 2x15 48 88.9 % 51.8 % 1.72 1.81 0.85 2.1 LF T174 CLA conjug. linoleic acid 1% fat+ Park 01->11737953 1.71 42 1.8 both Rs' dmh 6x15 30 12 30 7 30 1.71 0.60 0.33 1.8 CLA T175 estrone other+ Guo Brown. 04->14704314 1.70 41 M aom ? 73 % 43 % 1.70 est T176 inulin raftinile 15% vs. cornstarch fibact+ Jacobsen 06->17044771 1.69 41 20 2.7 both Rf' aom 2x15 32 22 30 13 30 1.69 10 30 8 30 20 1.35 0.50 2.7 inu promot ACF T177 auraptene 500ppm //+dss /mice phyto+ Kohno Suz 06->16395701 1.67 40 60 3.2 post Mi' aom 10+dss 20 10 10 6 10 1.67 10 10 4 10 60 5.40 1.70 3.2 aur T178 aspirin 400ppm NSAI Reddy Rao 93->8353834 1.66 40 84 2.4 post Rf' aom 2x15 52 78 % 47 % 1.66 34 % 5.5 % 84 1.70 0.70 2.4 asp T179 oltipraz 200ppm phyto Rao Rivens. 93->8495412 1.66 40 40 2.3 init Rf' aom 2x15 ? 78 % 47 % 1.66 78 % 47 % 40 1.60 0.69 2.3 olt T180 vit. D 0.1ppm+ calcium 1.5% vitAD Beaty 93->8421225 1.66 40 44 post Rf' dmh 1x200 32 12 30 7 29 1.66 11 30 6 29 44 vD T181 calcium 2% vs 0.8% (carbonate) miner+ AdellCarc. 97->9369116 1.65 39 2.9 both Rs' dmh 26x15 27 24 28 13 25 1.65 4.10 1.40 2.9 cal T182 B-sitosterol 0.2% //MNU fat Raicht 80->7356523 1.64 39 60 ? R mnu ? 100 % 61 % 1.64 100 % 40 % 60 2.50 Bsi T183 fish oil 16% vs soy 4% /mice fat Lindner 91->2017394 1.64 39 63 2.1 both Ms dmh 11x20 25 90 % 55 % 1.64 48 % 18 % 63 3.24 1.55 2.1 fis T184 caloric restriction -30% other Kumar 90->2393850 1.63 39 42 2.1 post Rf' aom 2x15 32 85 % 52 % 1.63 26 % 15 % 42 1.50 0.70 2.1 CR T185 fish oil //MNU fat+ Kenar 07->18041586 1.63 38 38 both Rf mnu 2x12 ir 32 13 15 8 15 1.63 13 15 8 15 38 fis T186 ursodeoxycholic 0.4% //+dss /mic. other+ Kohno Suz 07->17438113 1.63 38 56 3.7 post Mi' aom 10+dss 20 13 20 8 20 1.63 9 20 4 20 56 3.70 1.00 3.7 urs T187 selenocyanate benzyl 25ppm other Reddy Sug. 87->3664491 1.62 38 70 2.0 init Rf' aom 2x15 34 21 27 13 27 1.62 10 27 3 27 70 1.62 0.81 2.0 sel T188 vit. D 24R25 5ppm vitAD Taniyama 00->10657954 1.61 38 2.7 post Rf' dmh 4x40&+ 26 92 % 57 % 1.61 2.66 0.97 2.7 vD T189 celecoxib 0.1% /mice NSAI+ Toth-Coles 05 1.61 38 6.8 both Ms'' dmh 10x20 26 29 30 18 30 1.61 14.60 2.13 6.8 cel T190 voluntary exercise <2 miles/d other Reddy Su. 88->3191484 1.61 38 63 2.8 post Rf' aom 2x15 38 66 % 41 % 1.61 52 % 19 % 63 1.22 0.44 2.8 exe T191 meat low 25% vs 60% other Reddy Nar. 76->988189 1.60 38 2.0 both Rf' dmh 20x10 30 16 28 10 28 1.60 1.00 0.50 2.0 mea T192 selenocyanate pXSSG 56ppm other Rao Wang 01->11325834 1.60 37 1.5 post Rf' aom 2x15 38 83 % 52 % 1.60 2.00 1.30 1.5 sel T193 Low Fat 5% vs 20% lipid mix. fat Rao Hirose 01->11280748 1.59 37 67 3.9 post Rf' aom 2x15 38 100 % 63 % 1.59 47.4 % 15.8 % 67 5.14 1.31 3.9 LF T194 curcumin 4% /mice phyto Huang 94->7954412 1.58 37 63 2.6 both Mf aom 6x10 27 93 % 59 % 1.58 40 % 15 % 63 5.63 2.17 2.6 cur T195 maltitol 5% fibact Tsukamur. 98->9482760 1.58 37 2.1 both Rf' dmh 14x20 27 15 20 10 21 1.58 1.20 0.57 2.1 mal T196 bran wheat vs resist.starch fibact Young 96->8566598 1.57 36 1.8 both Rs dmh 10x20 30 88 % 56 % 1.57 2.00 1.10 1.8 bra T197 calcium carbonate 1%vs.5% LF miner+ Pence 96->8837860 1.57 36 post Rf' aom 2x12 29 11 40 7 40 1.57 cal T198 raloxifene 1 ppm other+ Rao-Janak. 06 1.56 36 2.7 both Rf' aom 2x15 48 100 64 1.56 1.00 0.37 2.7 ral T199 lactoferrin (bovine) 2% other+ Fujita 04->15312680 1.56 36 1.5 post Rf' aom 3x15 40 14 20 9 20 1.56 1.00 0.65 1.5 lac T200 mofarotene 100ppm vitAD Tanaka M. 96->7634421 1.55 35 76 1.7 post Rf' aom 3x20 36 17 22 9 18 1.55 15 22 3 18 76 1.20 0.70 1.7 mof T201 DEHA 0.6% /mice other Nyce 84->6228341 1.53 35 36 5.1 both Mb'' dmh 22x21 30? 26 26 17 26 1.53 11 26 7 26 36 12.80 2.50 5.1 deh T202 aceglatone 2% phyto Yoshimi 01 1.52 34 init Rf' aom 2x15 36 50 % 33 % 1.52 ace T203 omeprazole 40æM/kg NSAI Penman 93->8244144 1.50 34 3.0 both Rs'' aom 12x10 27 19 20 12 19 1.50 3.00 1.00 3.0 ome T204 calcium lactacte 3g/l miner VinasSall. 98->10023319 1.50 33 1.7 both Rs dmh 18x21 ? 28 29 18 28 1.50 2.20 1.30 1.7 cal T205 aspirin 300ppm NSAI+ Molck 02->12183071 1.50 33 both Rf' aom 2x15 18 9 16 6 16 1.50 asp T206 bran wheat 20% LoFatChow fibact+ Barbolt 80->6254207 1.50 33 3.6 both Rs' dmh 10x30 22 10 10 6 9 1.50 6.40 1.80 3.6 bra T207 flavonoid morin 500ppm phyto Tanaka K. 99->10426795 1.50 33 62 2.0 post Rf' aom 3x15 28 9 12 7 14 1.50 9 12 4 14 62 1.00 0.50 2.0 fla T208 isoliquiritigenin 100ppm /mice phyto+ Baba 02->11853176 1.50 33 3.7 both My' aom 2x10 24 24 24 10 15.0 1.50 14.60 3.90 3.7 iso T209 melatonin 20mg/l water other Anisimov 97->9276629 1.50 33 2.5 both Rl dmh 5x21 26 21 21 14 21 1.50 3.80 1.50 2.5 mel T210 sour milk 28% (undried) fibact+ Tanako 85 1.50 33 3.4 ? Rf' dmh 16x20 26 9 9 6 9 1.50 3.40 1.00 3.4 sou T211 lactoferrin bovin 2% other Sekine 97->9263527 1.48 32 74 1.7 post Rf' aom 3x15 37 31 40 21 40 1.48 23 40 6 40 74 1.25 0.73 1.7 lac T212 fish oil 18% vs corn oil fat Reddy Sug. 88->3180073 1.47 32 55 1.8 post Rf' aom 2x15 38 25 27 17 27 1.47 22 27 10 27 55 1.80 1.00 1.8 fis T213 JTE-522 COX2-inhib. 150ppm NSAI+ Wei 05->15455344 1.47 32 40 1.3 both Rf' dmh 4x40 40 25 27 17 27 1.47 25 27 15 27 40 1.44 1.07 1.3 jte T214 tea black, extract 50mg/kg phyto Caderni 00->11062155 1.46 32 0 1.6 post blind Rf' aom 10x7.4 16 19 22 13 22 1.46 45 % 45 % 0 2.54 1.54 1.6 tea T215 veget. & fruits 20% //MNG phyto Rijnkels 97->9103314 1.46 32 70 2.0 both Rw' mnng 5x6 35 73 % 50 % 1.46 43 % 13 % 70 1.37 0.67 2.0 veg T216 fish oil 17% vs lipid mix. fat Rao Hirose 01->11280748 1.45 31 50 3.1 post Rf' aom 2x15 38 100 % 69 % 1.45 47.4 % 23.6 % 50 5.14 1.67 3.1 fis T217 calcium //MNU miner+ Kenar 07->18041586 1.44 31 31 both Rf mnu 2x12 ir 32 13 15 9 15 1.44 13 15 9 15 31 cal T218 Bifidobact. longum 2% fibact Singh 97->9111222 1.44 30 2.2 both Rf' aom 2x15 40 23 30 16 30 1.44 1.80 0.83 2.2 bif T219 BB protease inh. 0.1%/mice phyto Billings 90->2372868 1.43 30 45 1.4 both Md dmh 20x ? 22? 13 19 11 23 1.43 12 19 8 23 45 0.68 0.48 1.4 bbi T220 citrus pulp 15% fibact Reddy Mor. 81->6259401 1.43 30 38 1.9 both Rf' aom 90 % 63 % 1.43 63 % 39 % 38 3.40 1.78 1.9 cit T221 indomethacin 2mg/kg NSAI+ Brown 01->11302965 1.43 30 6.1 post Rs dmh 5x30 23 12 12 7 10 1.43 4.25 0.70 6.1 ind T222 olive oil 5% vs safflower oil fat+ Bartoli 00->10644312 1.43 30 30 3.1 both Rf' aom 11x7.4 14 10 12 7 12 1.43 10 12 7 12 30 2.50 0.80 3.1 oli T223 treadmill exercise 5h/d other Thorling 94->11304908 1.43 30 100 1.6 post Rf' aom 3x15 38 31 31 21 30 1.43 10 30 0 30 100 1.80 1.13 1.6 exe T224 vit. D3 -OH 0.04æg//MNU vitAD Kawaura 90->2265414 1.42 29 27 1.4 both Rf mnu 1x? 40 17 25 12 25 1.42 11 % 8 % 27 0.96 0.68 1.4 vD3 T225 cryptoxanthin 25ppm //MNU phyto Narisawa 99->10595732 1.41 29 1.2 both Rf'' mnu ir6x2mg 30 24 25 17 25 1.41 1.70 1.40 1.2 cry T226 Lactobac. rhamnos. GG 2E10 fibact Goldin 96->8710689 1.41 29 2.2 init - dmh ? 100 % 71 % 1.41 3.70 1.70 2.2 lac T227 perillyl alcol 0.2% phyto Reddy Wa. 97->9012468 1.40 29 29 1.2 both Rf' aom 2x15 52 1.40 77.7 % 55.5 % 29 1.35 1.13 1.2 per T228 selenised casein 1ppm Se other+ McIntosh 06->16898865 1.40 29 2.1 both Rs' aom 2x15 26 14 25 10 25 1.40 1.08 0.52 2.1 sel T229 High Fat 24% Crisco vs 5% fat+ Nauss 83->6871849 1.40 29 0.9 both Rs' dmh 5x15 po 60 30 39 22 40 1.40 1.50 1.60 0.9 HF T230 B-carotene 50ppm phyto Yamamot. 94->7954354 1.39 28 28 1.3 both Rs' dmh 12x20 26 1.39 23 30 11 20 28 1.10 0.85 1.3 Bca T231 calcium 1.5% vs % lactate HF miner+ Belbraouet 96->8818389 1.39 28 57 0.8 post Rw'' mnu 2x2.5 32 25 28 18 28 1.39 25 % 10.7 % 57 2.30 2.90 0.8 cal T232 pectin 10% vs no fiber fibact Heitman 92->1316814 1.38 27 27 1.5 post Rs' dmh 8x12 24 22 30 16 30 1.38 22 30 16 30 27 0.93 0.63 1.5 pec T233 aspirin 1800 ppm NSAI+ Li Schut 99->10190557 1.37 27 14 both Rf' aom 2x15 44 22 31 15 29 1.37 16.1 % 13.8 % 14 asp T234 Lactobac. bulg. milk2.5g/d fibact Balanski 99->10660098 1.36 27 1.7 both R6'' dmh 20x21 35 96.6 % 70.8 % 1.36 2.90 1.70 1.7 lac T235 beer (Munich) 100% drink phyto+ Nozawa 04->14648707 1.36 26 22 1.8 both Rf' aom 2x15 41 19 22 14 22 1.36 18 22 14 22 22 1.95 1.09 1.8 bee T236 plumbagin 200ppm phyto Sugie 98->9619875 1.35 26 3 1.9 init Rf' aom 3x15 35 13 28 10 29 1.35 8 28 8 29 3 0.71 0.38 1.9 plu T237 raspberries 10% phyto Harris 01->11962247 1.34 25 3.5 post Rf' aom 2x15 33 67 % 50 % 1.34 2.33 0.67 3.5 ras T238 synbiotics FosInuLactBif 10% fibact+ Femia 02->12419846 1.33 25 64 2.1 both blind Rf' aom 2x15 31 46 64 35 65 1.33 22 64 8 65 64 2.05 1.00 2.1 syn T239 wheat aleurone flour 33% fibact McIntosh 01->11208949 1.33 25 1.6 both Rs' aom 2x20 26 80 % 60 % 1.33 1.35 0.85 1.6 whe T240 curcumin 0.6% phyto Kawamori 99->9973206 1.33 25 29 2.3 post Rf' aom 2x15 36 85 % 64 % 1.33 76 % 54 % 29 2.03 0.89 2.3 cur T241 bran wheat 24% //MNNG fibact Sinkeldam 90->2153449 1.33 25 0 1.9 both Rw' mnng 5x6 33 73 % 55 % 1.33 10 % 10 % 0 3.00 1.60 1.9 bra T242 stearic acid 5% vs linoleic 5% fat+ Sakaguchi 84->6704963 1.32 24 1.5 both Rd' aom 11x7.4 26 100 % 76 % 1.32 2.68 1.79 1.5 ste T243 Lactobac.mix.EtOH extr. 2% /mice fibact+ Fukui 01->11496319 1.30 23 74 2.0 both Mi' dmh 10x20 25 23 23 23 30 1.30 3 23 1 30 74 11.10 5.50 2.0 lac T244 N-acetylcystein .2%//dss mice other Seril-Liao 01 1.30 23 1.4 both Mc aom + dss ? 23 26 17 25 1.30 2.09 1.53 1.4 Nac T245 promegranate seed oil 0.1% (CLA) fat+ Kohno 04->15182427 1.30 23 54 1.9 both Rf' aom 2x20 32 13 16 10 16 1.30 13 16 6 16 54 2.50 1.31 1.9 pro T246 ONO-8711 EP1-antag. 800ppm NSAI+ Niho 05->15904466 1.28 22 22 1.4 both Rf' aom 2x15 31 34 35 25 33 1.28 34 35 25 33 22 3.97 2.91 1.4 ono T247 orange juice as drink phyto Miyagi 00->10890034 1.28 22 1.2 post Rf' aom 2x15 33 73 % 57 % 1.28 1.20 0.97 1.2 ora T248 bran wheat 20% LoFatChow fibact+ Barbolt 78->652805 1.28 22 both Rs'' dmh 10x22 22 23 40 18 40 1.28 bra T249 bacteria gut flora conv. vs.germ-free fibact+ Horie 99->10443953 1.27 21 1.9 both Mq dmh 10x15 33 14 19 11 19 1.27 2.60 1.40 1.9 bac T250 fish oil 15% vs corn oil 15% fat Chang 97->9111206 1.25 20 20 both Rs' aom 2x15 36 1.25 52 74 37 66 20 fis T251 sphingomyelin 250ppm /mice fat Schmelz 96->8895747 1.25 20 40 1.0 post Mf dmh 6x20 34 24.5 % 19.6 % 1.25 15 % 9 % 40 1.30 1.30 1.0 sph T252 bran wheat 15% vs.5%cell. LowFat fibact+ Reddy Mor. 81->6259401 1.24 20 37 2.2 both Rf' aom 10x8 30 86 96 36 50 1.24 60 96 20 51 37 3.45 1.55 2.2 bra T253 calcium carbonate 2%vs.5 +cholic miner+ Pence 95->7728952 1.24 19 post Rf' aom 2x12 34 40 47 24 35 1.24 cal T254 folate deficency vs 8mg/kg vitB LeLeu 00->11133816 1.23 19 77 1.8 both Rs' aom 3x15 26 79 % 64 % 1.23 52 % 12 % 77 1.68 0.96 1.8 fol T255 oltipraz 200ppm phyto+ Sivananthan 05 1.23 19 1.3 post Rs aom 2x15 29 37 % 30 % 1.23 0.47 0.37 1.3 olt T256 bran wheat 10% fibact+ Wijnands 04->15304309 1.22 18 1.8 post Rf' aom 3x15 35 24 26 22 29 1.22 3.29 1.86 1.8 bra T257 etodolac 10 mg/kg //dss /mice NSAI+ Mukawa 08->18202786 1.21 18 2.3 post M dss 2x7d 3% ? 14 14 14 17 1.21 3.00 1.29 2.3 eto T258 galacto-oligosaccharide 20% fibact Wijnands 01->11159750 1.21 17 10 1.1 both Rf' aom 2x15 43 83.6 % 69.2 % 1.21 58.2 % 52.3 % 10 2.00 1.90 1.1 gos T259 calcium 0.5%vs.25 HF20%SOfolic- miner+ Ranhotra 99->10798340 1.20 17 1.8 both Rf' dmh 12x20 22 12 20 10 20 1.20 0.90 0.50 1.8 cal T260 pectin 6% vs cellulose 6% fibact Chang 97->9111206 1.20 17 16 both Rs' aom 2x15 36 1.20 51 74 38 66 16 pec T261 mofezolac (COX1) 1200ppm NSAI+ Niho Kita. 06->16984374 1.19 16 16 1.4 both Rf' aom 2x15 32 50 53 27 34 1.19 50 53 27 34 16 3.81 2.68 1.4 mof T262 calcium 2% cholic acid diet miner Pence 95->7728952 1.18 15 -12 1.2 post Rf' aom 2x12 34 85 % 72 % 1.18 25 % 28 % -12 1.80 1.50 1.2 cal T263 valspodar PGP-inhib 15mg/kg other+ Kankesan 06->16619498 1.18 15 63 2.0 post Rf' dmh 100+PH 35 22 24 14 18 1.18 18 24 5 18 63 2.00 1.00 2.0 val T264 buckwheat protein 28% vs casein phyto+ Liu Z 01->11385078 1.18 15 47 1.3 both Rs' dmh 8x20 18 20 20 17 20 1.18 17 20 9 20 47 4.00 3.00 1.3 buc T265 garlic aged extr. AGE 4% phyto+ Katsuki 06->16484578 1.17 14 3.7 both Rs' dmh 20x20 26 14 18 12 18 1.17 3.70 1.00 3.7 age T266 benzyl thiocyanate 400ppm phyto Sugie 94->8055633 1.15 13 -18 0.7 post Ra'' mam 3x25 46 15 18 13 18 1.15 11 18 13 18 -18 1.50 2.10 0.7 ben T267 retinamide 4-HPR 2mmol/kg vitAD Zheng 97->9395211 1.15 13 64 2.3 both Rf' aom 2x15 36 96.7 % 84 % 1.15 33.3 % 12 % 64 3.73 1.64 2.3 ret T268 n-3 PUFA accum.transg.fat-1 mice fat+ Nowak 07->17634405 1.14 13 13 1.8 both Mb'tr aom 10+dss 11 11 11 14 16 1.14 11 11 14 16 13 4.20 2.40 1.8 n-3 T269 MMTS 80ppm phyto Reddy Kaw. 99->10426822 1.13 12 12 1.3 post Rf' aom 2x15 52 85 % 75 % 1.13 76 % 67 % 12 2.00 1.50 1.3 mmt T270 diabenol 0.1mg/ml water 5d/7 other+ Popovich 05->15743682 1.05 5 1.4 both Rl' dmh 5x21 26 18 19 18 20 1.05 5.47 3.80 1.4 dia T271 DHA 1ml/d //PhIP fat Takahashi 97->9364003 1.05 5 5 1.6 both Rf' aom 2x15 36 52 54 45 49 1.05 52 54 45 49 5 3.80 2.40 1.6 dha T272 veget. & fruits 20% phyto Alink 93->8453729 1.04 4 5 1.9 both Rw' dmh 10x50 36 84 % 81 % 1.04 79 % 75 % 5 3.42 1.78 1.9 veg T273 5ASA aminosalicylic 20mg/kg NSAI+ Brown 00->11007109 1.00 0 2.4 both Rs' dmh 5x30 23 100 % 100 % 1.00 4.25 1.78 2.4 asa T274 acetoxychavicol acet. 100ppm phyto+ Orita 04->15200164 1.00 0 0 1.5 post Rs'' dmh 5x40+2D 37 9 18 9 18 1.00 7 18 7 18 0 1.11 0.72 1.5 ace T275 bran wheat microfib.20%mice fibact Takahashi 99->10454254 1.00 0 2.6 both Mf aom 6x10 33 18 19 18 19 1.00 7.50 2.90 2.6 bra T276 butyrate enemas //tnbs+aom fibact+ D'Argenio 96->8964397 1.00 0 1.7 ? Rw' aom 90+tnbs 27 10 10 10 10 1.00 2.67 1.54 1.7 but T277 calcium low 0.1% vs 1% miner Bull-Bird 87 1.00 0 1.7 both Rs' aom 8x8 26 100 % 100 % 1.00 5.70 3.30 1.7 cal T278 etanercept 3mg/kg TNFinhib.//+dss other+ Popivanova 08->18219394 1.00 0 1.8 post Mb'' aom 12+dss 10 10 10 11 11 1.00 18.30 9.90 1.8 eta tum.size/1.5 T279 isoliquiritigenin 300ppm /mice phyto+ Chin Jung 07->17516657 1.00 0 1.3 post Ms'' dmh 16x10 36 44 44 25 25 1.00 5.35 4.03 1.3 iso T280 Na2SO4 0.25% low fecal pH fibact Samelson 85->3973888 1.00 0 1.5 both Rs' dmh 16x15 28 100 % 100 % 1.00 3.50 2.30 1.5 sul T281 Onopordum cyn.extr. 0.3ml/mouse ! phyto+ El-Najjar 07->17487413 1.00 0 7.0 init Mb'' dmh 30x20 30 8 8 8 8 1.00 35.70 5.10 7.0 ono dubious T282 reovirus T3 10E9/wk x5 other+ Alain 07->17627293 1.00 0 0 1.6 post Rs'' aom 4x15 27 8 8 8 8 1.00 8 8 8 8 0 2.40 1.50 1.6 reo T283 tannin red ald. 10mg/kg mice phyto Gali-Muht. 01->11588891 1.00 0 2.8 init Mb dmh 24x20 25 100 % 100 % 1.00 22.20 8.00 2.8 tan T284 TGF-B1 2ng/d other Mikhailow 98->9808532 1.00 0 2.8 both Rc dmh 5x18 15 100 % 100 % 1.00 9.40 3.40 2.8 tgf T285 thymoquinone 5mg/kg (Nigella) /mi. phyto+ Gali-Muht. 08->18366456 1.00 0 4.1 both Mb'' dmh 10x20 20 30 30 30 30 1.00 17.80 4.30 4.1 thy T286 vit. D3 1.25diOH 5x0.4æg ! vitAD Belleli 92->1335376 1.00 0 0 2.1 init Rr' dmh 5x18 14 5 5 7 7 1.00 5 5 7 7 0 6.00 2.85 2.1 vD3 T287 vit. D3 2UI/g stress diet vitAD Mokady 00->11341047 1.00 0 48 6.0 both Rr' dmh 5x18 15 100 % 100 % 1.00 60 % 31 % 48 14.90 2.50 6.0 vD3 T288 wine extract (red) 0.11% phyto+ Femia 05->15309424 1.00 0 1.6 post blind Rf' dmh 10x30 26 24 24 22 22 1.00 2.15 1.35 1.6 win T289 bitter melon seed oil 0.01% (CLA) fat+ Kohno 04->15170673 0.95 -5 48 1.6 both Rf' aom 2x20 32 15 18 14 16 0.95 15 18 7 16 48 2.50 1.56 1.6 bit T290 hydroquinone HTHQ 0.5% //PhIP other+ Hirose 99->10503899 0.95 -5 2.5 post Rf' dmh 4x40 36 20 21 19 19 0.95 9.10 3.60 2.5 hyd T291 butyrate pellets 1.5% fibact Caderni 01->11238196 0.88 -14 0.8 post blind Rf' aom 2x15 33 79 % 90 % 0.88 1.60 2.00 0.8 but T thiazolidinedione PPARgam 10mg/kg Ppar+ Su Nesela 08->18546290 6.75 85 both no Mc" aom 4x10 12+28 6 16 1 18 6.75 thia T Calcium+vit.D /NWD Western diet miner+ Newmark 09->19017685 8.00 88 33 both no Mc NO carcin. 104 4 15 0.5 15 8.00 0.33 0.01 33 cal No carcinog T Calcium+vit.D /NWD Western diet miner+ Yang Kuri. 08->18829535 8.83 89 11 both no Mc NO carcin. 102 53 % 6 % 8.83 0.67 0.06 11.2 cal No carcinog Idem Newmark09 selenium in milk prot. 1ppm other+ Hu McInto. 08->18559541 2.88 65 83 4.5 both blind Mc' aom 4x15 36 10 26 4 30 2.88 5 26 1 30 83 0.58 0.13 4.5 sel T bean fractions /mice phyto+ Bobe 08->18444172 10.7 91 87 post no Mo' aom 2x7 27 22 40 2 39 10.7 4 40 0.5 39 87 bea T Fat1 n-3 transgenic /mice //+dss fat+ Jia Chapki. 08->18483285 1.27 21 12 2.0 both blind Mc aom 12+dss 22 17 17 15 19 1.27 17 17 15 19 12 2.12 1.05 2.0 n-3 T g-tocopherol oil 0.3% /mice //+dss fat+ Ju Hao 09->19155443 3.29 70 8.0 both no Mf' aom 4x5+dss 21 7 17 2 16 3.29 2.40 0.30 8.0 gtoco T Geranyloxy-FeruIic Acid 0.1% phyto+ Miyamoto 08->18791932 1.50 33 37 2.4 post no Mi' aom 1x10+dss 19 20 20 10 15 1.50 19 20 9 15 37 5.60 2.33 2.4 gap T canola oil 15% vs. con oil fat+ Bhatia 11->21264790 1.26 21 2.4 post no Rf' aom 2x15 30 24 24 19 24 1.26 3.1 1.3 2.4 can T lutein 20ppm phyto+ Reynoso 11-> 21128180 2.20 55 1.3 both no Rs' dmh 8x21 20 6 15 4 22 2.20 1.33 1.00 1.3 lut T diosgenin 100ppm //+dss phyto+ Miyoshi 11->21367960 1.60 38 50 4.0 post no Mi' aom 1x10+dss 20 8 15 5 15 1.60 8 15 4 15 50 4.33 1.07 4.0 dio T yam sanyaku 100ppm //+dss phyto+ Miyoshi 11->21367960 2.00 50 88 8.2 post no Mi' aom 1x10+dss 20 8 20 4 15 2.00 8 15 1 15 88 4.33 0.53 8.2 yam T atrovastatin 100 +naproxen 150 ppm combi+ Suh Reddy 11->21764859 2.72 63 63 6.6 post no Rf' aom 2x15 45 23 31 9 33 63 1.77 0.27 6.6 ato T naproxen 150 ppm NSAI+ Suh Reddy 11->21764859 1.31 24 24 1.4 post no Rf' aom 2x15 45 23 31 17 30 24 1.77 1.23 1.4 nap