Colon tumor prevention in Man. Go to: http://www.inra.fr/reseau-nacre/sci-memb/corpet/indexan.html Data ranked by WeighedMeanPotency Corpet D.E. & Pierre F. 2005, Eur.J.Cancer. Updated 2008 line # Agent or Diet Study Qual. Reference (click name for abstract)-> - RR - Relative Risk (95% conf.int.) size: treated number Length, months Daily dose Fem. Male Both Colon endpoint Primary endpoint . Weighed mean /agent Agent H01 DFMO+sulindac top Meyskens 08-> 0.3 0.30 (0.18-0.49) 138 36 500+150 B Adeno. rec. 0.3 D+sul H02 dry bean ! NR Lanza 06->16772456 0.35 0.35 (0.18-0.69) 1000? 36 32g/d B Adv.adeno. rec. Adeno. rec. 0.35 bean H03 Lactulose ! NP Roncucci 93->8449125 0.41 0.41 (0.21-0.81) 61 18 20 g B Adeno. rec. 0.41 Lac H04 Selenium ! EP Clark 96->8971064 0.42 0.42 (0.18-0.95) 653 54 200 ęg B CRC incid. Skin cancer 0.64 Se H05 Se,Ca,vitC,vitE,Bcar ! SS Hofstad 98->9586828 0.71 0.71 (0.5-1.0) 42 36 100ęg+1.6 g B Adeno. rec. Polyp growth 0.64 SeMix H06 Se,Zn,vitC,vitE,Bcar ! EP Hercberg 04->15557412 0.71 0.71 (0.39-1.31) 2520 90 100ęg+176mg M CRC incid. All cancers 0.64 SeMix H07 Sulindac sulfide ! EP Arber 06->16150858 0.65 0.65 (0.43-0.99) 33 12 400 mg B Therap.resp. Polyp size 0.65 ExS H08 cox Celecoxib top Bertagnolli 06->16943400 0.67 0.67 (0.59-0.77) 685 36 400 mg B Adeno. rec. 0.67 cox H09 cox Celecoxib top Bertagnolli 06->16943400 0.55 0.55 (0.48-0.64) 671 36 800 mg B Adeno. rec. 0.67 cox H10 cox Celecoxib top Arber 06->16943401 0.64 0.64 (0.56-0.75) 933 36 400 mg B Adeno. rec. 0.67 cox H11 cox Celecoxib ! SS Steinbach 00->10874062 0.72 0.72 polyp/patient 30FAP 6 800 mg B Polyp no. Polyp numbr 0.67 cox H12 cox Rofecoxib top Baron 06->17087947 0.76 0.76 (0.69-0.83) 1277 36 25 mg B Adeno. rec. 0.67 cox H13 Sulindac ! SS Giardiello 02->11932472 0.78 0.78 (0.4-1.5) 21FAP 48 300 mg B Polyp no. Polyp numbr 0.78 Sul H14 Calcium top Bonithon 00->11073017 0.66 0.66 (0.38-1.17) 176 36 2 g B Adeno. rec. 0.79 Ca H15 Calcium top Baron 99->9887161 0.85 0.85 (0.74-0.98) 464 18 1.2 g B Adeno. rec. 0.79 Ca H16 Calcium +Mix ! SS Hofstad 98->9586828 0.71 0.71 (0.5-1.0) 42 36 1.6 g B Adeno. rec. Polyp growth 0.79 Ca H17 Aspirin ! EP Gann 93->8331682 0.86 0.86 (0.68-1.10) 11035 60 162 mg M Adeno. Incid. Cardiovasc. 0.85 Asp H18 Aspirin ! SS Benamouzig 03->12891533 0.61 0.61 (0.37-0.99) 60 12 300 mg B Adeno. rec. 0.85 Asp H19 Aspirin top Sandler 03->12621132 0.65 0.65 (0.46-0.91) 317 31 325 mg B Adeno. rec. 0.85 Asp H20 Aspirin top Baron 03->12621133 0.81 0.81 (0.69-0.96) 377 33 81 mg B Adeno. rec. 0.85 Asp H21 Aspirin top Logan 08->18022173 0.79 0.79 (0.63-0.99) 434 30 300 mg B Adeno. rec. 0.85 Asp H22 Aspirin ! SS Benamouzig 03->12891533 0.85 0.85 (0.57-1.26) 66 12 160 mg B Adeno. rec. 0.85 Asp H23 Aspirin top Baron 03->12621133 0.96 0.96 (0.81-1.13) 372 33 325 mg B Adeno. rec. 0.85 Asp H24 Lactobacilus casei ! NP Ishikawa 05->15828052 0.85 0.85 (0.56-1.27) 192 48 3x10E10 M Adeno. rec. 0.85 L.cas H25 Ursodeoxycholic acid top Alberts 05->15928305 0.88 0.88 (0.73-1.05) 661 32 8-10 mg/kg B Adeno. rec. 0.88 Urso H26 Wheat bran top Alberts 00->10770980 0.88 0.88 (0.7-1.1) 719 35 +11 g B Adeno. rec. 0.98 bran H27 Wheat bran top McKeown 94->7730878 1.2 1.2 (0.6-2.2) 99 24 +15 g B Adeno. rec. 0.98 bran H28 Wheat bran top MacLennan 95->7473832 1.2 1.2 (0.8-2.0) 150 48 +25 g B Adeno. rec. 0.98 bran H29 Wheat bran ! NP Ishikawa 05->15828052 1.31 1.31 (0.87-1.97) 191 48 7.5 g M Adeno. rec. 0.98 bran H30 Beta-carotene ! EP Malila 99->10385137 0.98 0.98 (0.71-1.35) 7761 78 20 mg M Adeno. Incid. Lung cancer 1.01 Bcar H31 Beta-carotene top Greenberg 94->8008027 1.01 1.01 (0.85-1.20) 359 48 25 mg B Adeno. rec. 1.01 Bcar H32 Beta-carotene top MacLennan 95->7473832 1.5 1.5 (0.9-2.5) 156 48 20 mg B Adeno. rec. 1.01 Bcar H33 Beta-carotene ! EP Hennekens 96->8602179 1 1 not signif. 11035 144 25 mg M All cancers Cardiovasc. 1.01 Bcar H34 Aspirin ! EP Cook 05->15998890 0.97 0.97 (0.77-1.24) 19934 121 50 mg F CRC incid. All cancers 1.04 Asp H35 Aspirin ! NR Sturmer 98->9556464 1.07 1.07 (0.67-1.70) 3489 144 162 mg M CRC incid. All cancers 1.04 Asp H36 Aspirin ! EP Gann 93->8331682 1.15 1.15 (0.80-1.65) 11037 60 162 mg M CRC incid. Cardiovasc. 1.04 Asp H37 Fruits & veg. top Schatzkin 00->10770979 1 1.00 (0.90-1.12) 958 36 +2serv B Adeno. rec. 1.07 F&V H38 Fruits & veg. ! WI Beresford 06->16467233 1.08 1.08 (0.90-1.29) 19541 97 +1.3serv F CRC incid. 1.07 F&V H39 Calcium +vit.D3 top Wactawski 06->16481636 1.08 1.08 (0.86-1.34) 18176 84 1 g +400 UI F CRC incid. Hip fracture 1.08 Ca H40 Low fat top MacLennan 95->7473832 0.9 0.9 (0.6-1.5) 151 48 -7% B Adeno. rec. 1.08 Lfat H41 Low fat top Schatzkin 00->10770979 1 1.00 (0.90-1.12) 958 36 -10% B Adeno. rec. 1.08 Lfat H42 Low fat top McKeown 94->7730878 1.2 1.2 (0.6-2.2) 99 24 -9% B Adeno. rec. 1.08 Lfat H43 Low fat top Beresford 06->16467233 1.08 1.08 (0.90-1.29) 19541 97 -11% F CRC incid. 1.08 Lfat H44 Vit.C + vit.E ! SS McKeown 88->3293777 0.86 0.86 (0.51-1.45) 70 24 0.4+0.4 g B Adeno. rec. 1.1 VitCE H45 Vit.C + vit.E top Greenberg 94->8008027 1.08 1.08 (0.91-1.29) 380 48 1+0.4 g B Adeno. rec. 1.1 VitCE H46 Vit.C +vit.E +vit.A ! NP Roncucci 93->8449125 0.16 0.16 (0.06-0.43) 70 18 1 g +70+9mg B Adeno. rec. 1.1 VitCEA H47 Vit.E ! EP Malila 99->10385137 1.66 1.66 (1.19-2.32) 7768 78 50 mg M Adeno. Incid. Lung cancer 1.1 VitE H48 Vit.E ! EP Lee 05->15998891 1 1.00 (0.77-1.31) 19937 121 200 mg F CRC incid. Cardiovasc. 1.1 VitE H49 Folic +B6+B12 ! EP Lonn 06->16531613 1.36 1.36 (0.89-2.08) 2758 60 2.5+50+1 B CRC incid. Cardiovasc. 1.22 Fol H50 Folic acid top Cole 07->17551129 1.04 1.04 (0.90-1.20) 501 36 1 mg B Adeno. rec. 1.22 Fol H51 Folic acid top Logan 08->18022173 1.07 1.07 (0.85-1.34) 432 30 0.5 mg B Adeno. rec. 1.22 Fol H52 Folic acid ! SS Jaszewski 08->18680228 0.44 0.44 ade/patient 46 36 5 mg M Adenoma no. 1.22 Fol H53 Psyllium top Bonithon 00->11073017 1.67 1.67 (1.01-2.76) 198 36 3.5 g B Adeno. rec. 1.67 psyl H Aspirin MetaAnalysis M-A Cole-Logan 09->19211452 0.83 0.83 (0.72-0.96) 2698 33 81 to 325 Both Adeno. rec. 0.83 Asp H EPA eicosapentaenoic FFA !SS West-Clark 10->20348368 0.88 0.88 polyp/patient 28FAP 6 2 g B Polyp no. EPA H green tea extracts ! SS Shimizu 08->18990744 0.49 0.49 (0.24-0.99) 71 12 1.5 g B Adeno. rec. GTE H Aspirin [! SS] Bum Bishop 11->21543343 0.77 0.77 (0.54-1.10) 62FAP 17 600 mg B polyps no. polyps no. asp H Resistant starch [! SS] Bum Bishop 11->21543343 1.05 1.05 (0.73-1.49) 61 17 30 g B polyps no. polyps no. M curcumin [! SS] Carroll 11->21372035 0.62 11 ACF vs. 18 ACF 19 1 4 g B ACF no. PGE2/ACF