ACF chemoprevention in rodents colon. To see table, go to: http://corpet.net/min Data ranked by potency Corpet D.E. & Tache 2002, Nutrition and Cancer. Updated 2008 Line # Treatment //carcinogen (if not AOM), and /mice (if not rats) Category Author, year (click name to get abstract)-> Potency/ACF = times-fold reduction Percent inhibi- tion Potency on large ACF Potency on ACF SIZE Potency on Ab. Crypts Pro- tocol Blinded scoring Ro- dent Carcinogen N x dose Weeks of treatmt ACF No. contrl ACF No. treatd Large ACF contrl Large ACF treatd Crypt /ACF contrl Crypt /ACF treatd Agent (3 lett.) or comment A001 PEG-like pluronic F68 5% PEG Parnaud 01->11139319 75.7 99 85 1.5 114 post blind Rf'' aom 1x20 +1+4 53 1 17.0 0.2 peg A002 PEG 8000 5% //MNU PEG Corpet 00->10866305 56.0 98 58 2.0 112 post blind Rf' mnu 1x40 +1+4 56 1 5.8 0.0 peg A003 PEG 8000 5% * MDF * PEG+ Femia 07->17294441 52.0 98 post blind Rf' dmh 2x150 +1+14 5 0 10.80 peg A004 Bif.animalis fermtd.milk 30% //IQ fibact+ Tavan 02->11895863 29.2 97 both blind Rf' iq 250mg -0+15 7 0 IQ+meIQ+PhIP used A005 celecoxib 0.1% //dmabp NSAI+ Feng Neale 08->18156308 28.2 96 0.8 22 both blind Rf' dmabp 2x100 -2+10 11 0 2.55 3.25 cel A006 PEG 8000 5% PEG+ Tache 06->16716974 27.7 96 9.5 0.9 24.5 post blind Rf aom 1x20 +1+5 62 2 6.0 0.6 2.24 2.53 peg M4 st. A007 PEG 8000 5% PEG+ Tache 06->16716974 19.2 95 41 1.2 23.6 post blind Rf aom 1x20 +1+5 96 5 9.3 0.2 2.09 1.70 peg K5 st. A008 PEG 8000 5% PEG Corpet 99->10334212 17.8 94 104 2.3 41 post blind Rf'' aom 1x20 +2+16 107 6 58.0 0.4 2.90 1.30 peg A009 PEG 8000 5% PEG Parnaud 01->11139319 14.0 93 14 1.1 15 post blind Rf'' aom 1x20 +1+4 peg A010 etoricoxib 0.6mg/kg/d * MPL * NSAI+ Kanwar 07->17934920 12.3 92 both blind Rs' dmh 6x30 0+6? 37 3 eto mucosal plaque lesions ? A011 perilla oil 12%+ B-carotene combi Komaki 96->8824511 11.4 91 1.2 14 both no Rf' aom 3x15 -0+10 217 19 1.76 1.44 per A012 indole3carbinol 0.1% //PhIP ! phyto Guo 95->8603466 11.0 91 2.0 22 init no Rf' phip 7x50 -2+1 3 0 3.40 1.70 ind A013 PEG 8000 5% PEG+ Femia 07->17294441 10.9 91 1.3 14.8 post blind Rf' dmh 2x150 +1+14 166 15 3.48 2.58 peg A014 resveratrol Alfafa +B-gluc 30ppm phyto+ Kineman 07->17571969 10.3 90 post blind Mf'' aom 1x5 +1+6 22 2 res A015 PEG 8000 5% PEG Parnaud 99->10537289 7.94 87 30 1.3 10 post blind Rf'' aom 1x20 +1+4 127 16 6.0 0.2 2.30 1.80 peg A016 thymoquinone 5mg/kg.ip (Nigella) phyto+ Gali-Muhta. 08->18366456 7.58 87 70 init no Mb'' dmh 10x20 0+10 36 5 19.9 0.3 thy ?? A017 NO-aspirin NCX4016 //TNBS /N Bak 98->9627095 7.00 86 both blind Rw' aom 4x15 -0+4 NO- A018 sulindac sulfide 0.3, then 0.1% NSAI Wargovich 00->10837003 6.89 85 10 post blind Rf' aom 2x15 +4+8 193 28 70.0 7.0 sul A019 pioglitazone 200ppm Ppar-G Ppar+ Osawa 03->12557142 5.92 83 1.0 6.2 both blind Mb'' aom 2x10 -1+3 15 3 1.37 1.32 pio A020 sulindac 80ppm+ olive oil 15vs4% combi+ Schwartz 04->15309441 5.60 82 both no Rs' dmh 5x40 +9+11 91 16 sul A021 caffeate PEMC 500ppm phyto Rao Des. 93->8364913 5.59 82 21 1.0 5.6 both blind Rf' aom 2x15 -2+9 123 22 46.5 2.2 2.69 2.59 caf A022 rosiglitazone 200ppm Ppar-G Ppar+ Osawa 03->12557142 5.48 82 1.0 5.6 both blind Mb'' aom 2x10 -1+3 15 3 1.37 1.33 Toxic A023 PEG 8000 5% PEG Naigamw. 00->11156379 5.46 82 36 1.4 7.6 post blind Rf' aom 1x20 +1+14 38 7 22.5 0.6 3.11 2.31 peg A024 vit. D5 1a(OH)24-D5 0.4ppm vitAD+ Murillo 05->16051482 5.33 81 2.5 both no Rf' aom 2x10 -2+7 10 2 1.0 0.4 vitD A025 FOS fructooligosac. 9% fibact+ Sung 08->18361741 5.11 80 post no Rs' dmh 4x20 +0+12 225 44 fos A026 sulindac+ECGC 4mg/kg+0.01% combi Ohishi 02->11809530 4.62 78 3.9 init Rf' aom 3x15 -0+4 46 10 8.6 2.2 sul A027 tea white 2% drink water //PhIP ! phyto+ Santana 01->12094635 4.31 77 both Rf' phip 5x150 -2+6 6 1 tea A028 proanthocyanidins 1% (grape) phyto Singletary 01->11759289 4.27 77 4.6 both Rs'' aom 2x15 -3+23 gra A029 xylooligosaccharides XOS 6% fibact+ Hsu 04->15173423 4.18 76 9.3 post Rs' dmh 2x15 +1+5 16 4 2.8 0.3 xos > fos A030 troglitazone 30mg/kg Ppar Kohno 01->11346461 4.15 76 5.4 1.4 5.8 init blind Rf' aom 2x20 -1+1 tro A031 quercetin 3% =80% MTD phyto+ Volate 05->15831530 4.00 75 2.8 both Rf' aom 2x15 -1+4 184 46 28.0 10.0 que A032 CLA conjug.linoleic ac. 0.5% //IQ fat Liew 95->8603482 3.91 74 0.9 3.5 init Rf' iq 07x100 -1d+1d cla A033 cooking salt 4.4% miner Masaoka 00->10965523 3.89 74 1.0 3.9 init Rf' aom 3x15 -1+4 136 35 1.63 1.70 coo A034 perilla oil 12% vs olive oil fat Onogi 96->8681445 3.88 74 1.1 4.3 init Rf' aom 3x15 -1+5 155 40 1.68 1.54 per A035 PEG 8000 5% PEG+ Roy 06->16928827 3.85 74 2.8 post blind Rf' aom 2x15 +2+30 100 26 10.0 3.6 peg A036 Bifidobacter.1.7%+ inuline 5% fibact Rowland 98->9498277 3.71 73 2.3 post Rs aom 2x12 +1+12 130 35 37.0 16.0 Bif A037 piroxicam 0.02% * MDF * NSAI+ Femia 04->14604897 3.71 73 4.3 1.3 4.9 post blind Rf' aom 2x15 +1+15 8 2 1.7 0.4 11.00 8.40 pir A038 azadeoxycytidine 14mg/kg no-Se other+ Davis 02->11823593 3.70 73 1.1 3.9 both Rf' dmh 02x25 -3+9 91 25 2.68 2.52 aza A039 EGCG 0.5mg/ml //PhIP phyto+ Carter 07->17571968 3.65 73 0.9 post blind Rf' phip 7x100 +1+16 29 8 0.9 1.0 egcg A040 oltipraz 200ppm //MNU phyto+ Begleiter 03->12815004 3.62 72 3.3 init Rs' mnu 6x6.5 -1+0 47 13 5.8 1.8 olt A041 garlic+tomato paste 20+20mg/d ? phyto+ Sengupta 04->15142670 3.52 72 3.2 both Rs' aom 3x15 -0+12 30 8 13.6 4.2 gar A042 resveratrol 8mg/kgBW/d phyto+ Sengottuv. 06->16338953 3.52 72 3.6 both no Rw' dmh 15x20 0+30 100 29 22.3 6.2 res A043 butylhydroxyanisole 0.56% other Wargovich 92->1469905 3.50 71 init blind Rf' aom 2x15 -1+5 140 40 but A044 DFMO 0.4% /N Wargovich 92->1469905 3.50 71 init blind Rf' aom 2x15 -1+5 140 40 dfm A045 DFMO 0.4% /N Wargovich 96->9162301 3.45 71 init blind Rf' aom 2x15 -1+5 dfm A046 piroxicam 0.02% NSAI+ Femia 04->14604897 3.39 70 4.8 1.2 4.0 post blind Rf' aom 2x15 +1+10 210 62 61.5 12.8 2.96 2.50 pir A047 piroxicam 400ppm NSAI Wargovich 00->10837003 3.35 70 post blind Rf' aom 2x15 +4+8 124 37 pir A048 Aloe arboresc. leaf 5% phyto+ Shimpo 01->11746864 3.34 70 11 1.3 4.3 init Rf' aom 3x15 -1+4 204 61 7.9 0.7 1.75 1.37 Alo A049 sphingomyelin diOH 0.1%/mice fat Schmelz 97->9200154 3.33 70 1.2 4.0 post Mf'' dmh 30x6 +1+5 18 6 1.70 1.50 sph A050 sanshishi 2% phyto Fukutake 00->10893436 3.30 70 1.5 4.8 init Rf' aom 2x15 -0+4 150 45 1.77 1.21 san A051 celecoxib 0.15% * BCAC NSAI+ Yamada 01->11429049 3.29 70 1.6 5.1 both Rf' aom 3x15 -1+7 5 1 4.57 2.92 cel A052 sphingomyelin 0.1% /mice fat Schmelz 96->8895747 3.25 69 1.5 4.9 post Mf'' dmh 06x40 +1+5 sph A053 rutin 3% phyto Wargovich 00->10837003 3.24 69 post blind Rf' aom 2x15 +4+8 133 41 rut A054 TGF-B1 2ng/d other Mikhail. 98->9808532 3.20 69 1.2 3.8 both Rr' dmh 05x18 -1+7 tgf A055 inulin HP 7% + FOS 3% fibact+ Verghese 05 3.19 69 2.9 both no Rf' aom 2x16 -3+9 559 175 30.8 10.6 inu A056 herbal SKTK mix extr. 0.5% phyto+ Yoo BH 01->11411551 3.13 68 1.5 4.5 post Mi' dmh 10x? +0+5 22 7 2.90 2.00 her A057 auraptene 250ppm /mice *BCAC* phyto+ Hayashi 07->17571970 3.10 68 both no Ml'' aom 3x10 0+10 20 6 aur BCAC A058 piroxicam 400ppm NSAI Wargovich 00->10837003 3.06 67 init blind Rf' aom 2x15 -1+5 98 32 pir A059 starch vs sucrose-dextrin diet other Poulsen 01->11369133 3.05 67 12 both Rf' aom 2x15 -4+17 sta A060 zapotin 10mg/kg BW/d phyto+ Murillo 07->17516860 3.04 67 3.0 both no Mf'' aom 2x10 -2+8 14 5 2.4 0.8 zap A061 retinoic acid allTrans 190ppm vitAD Wargovich 00->10837003 3.02 67 3.4 post blind Rf' aom 2x15 +4+8 139 46 57.0 17.0 ret A062 wheat bran 20% vs no fibre fibact Ishizuka 96->8988644 3.01 67 0.6 1.9 init Rw' dmh 01x20 -1+4 24 8 1.73 2.75 whe A063 glucose vs sucrose bolus /mice other Stamp 93->8472347 3.00 67 init Mf'' aom 1x5 -14h glu A064 indomethacin 16ppm * BCAC * NSAI+ Morioka 05 2.97 66 post Rf' dmh 2x40 +0+6 11 4 ind A065 indomethacin 16ppm * BCAC * NSAI+ Yoshimi 04->15504245 2.97 66 3.4 post Rf' dmh 2x40 +1+8 11 4 ind A066 bean (garbanzo) flour 10% /mice ! phyto+ Murillo 04->15517915 2.93 66 11 both no Mc'' aom 2x10 -2+7 16 5 2.2 0.2 bea A067 piroxicam 125ppm 12to24wks NSAI Morishita 97->9369928 2.89 65 3.0 post Rf' aom 3x15 +10+22 pir A068 docosahexaenoic 0.5ml/d fat Takahashi 93->8504420 2.88 65 1.2 3.5 init Rf' dmh 03x20 -1d+4 doc A069 obacunone 200ppm phyto Tanaka 01->11159759 2.86 65 1.1 3.1 init blind Rf' aom 2x15 -1+2 oba A070 DFMO 0.4% /N Paulsen 97->9363993 2.85 65 6.2 both Rf' aom 2x7 -0+7 194 68 28.0 4.8 dfm A071 aspirin 10ppm NSAI Mereto 94->8124666 2.84 65 3.0 1.2 3.4 init Rs' dmh 02x25 145 51 70.0 23.0 2.65 2.14 asp A072 piroxicam 200ppm NSAI+ Nozawa 05->15968705 2.83 65 4.3 1.1 3.0 both Rf' aom 2x15 -1+4 77 27 8.1 1.9 2.27 2.13 pir A073 citrus unshiu 0.5% *BCAC* phyto+ Suzuki 06->17066427 2.83 65 post no Mc' aom 5x15 +1+8 24 9 cus BCAC A074 balsalazide 250mg/kg NSAI+ MacGregor 00->10853036 2.83 65 3.2 post Rf' aom 2x20 +0+8 181 64 73.0 23.0 bal A075 vit. D3 fluorin. F6-D3 2.5nM/kg vitAD+ Wali 02->12496057 2.83 65 3.7 init Rf' aom 2x20 -2+2 65 23 26.0 7.0 f6d A076 starch resistant 25% fibact Cassand 97->8970182 2.82 65 post Rs' dmh 02x25 +1+13 sta A077 silymarin 0.1% phyto+ Kohno 02->12216075 2.80 64 7.6 init Rf' aom 2x20 -1+3 140 50 16.8 2.2 sil A078 tetracycline 1.25% fibact Wargovich 00->10837003 2.78 64 init blind Rf' aom 2x15 -1+5 103 37 tet A079 piroxicam 200ppm NSAI Wargovich 95->7829266 2.78 64 8.0 post blind Rf' aom 2x15 +4+8 125 45 40.0 5.0 pir A080 docosahexaenoic 0.7ml/d //PhiP fat Takahashi 97->9364003 2.75 64 3.7 1.1 3.0 init Rf' phip 10x75 -4h 22 8 5.8 1.5 2.69 2.39 doc A081 taurine 1.2ppm other Wargovich 00->10837003 2.74 64 init blind Rf' aom 2x15 -1+5 tau A082 beet fiber 10% //Gamma Ray ! fibact Nagai 00->10867036 2.74 64 0.7 1.9 init Rw' gam.ray3x -1+5 0 0 1.30 1.80 bee A083 CLN conjugated linolenic acid 1% fat+ Kohno 02->11856476 2.70 63 6.0 1.1 3.0 init no Rf' aom 2x20 -1+3 108 40 9.4 1.6 1.95 1.76 cln A084 glycyrrhetinic acid 0.5% phyto Wargovich 96->9162301 2.70 63 init blind Rf' aom 2x15 -1+5 gly A085 ginseng red 1% phyto Li Wanib. 00->10798218 2.70 63 2.1 init Rf' dmh 04x20 -1+3 170 63 13.6 6.6 gin A086 citrus unshiu CUSM 0.5% phyto+ Suzuki 06->17066427 2.65 62 4.3 1.3 3.3 post no Mc' aom 5x15 +1+8 69 26 23.2 5.4 3.28 2.61 cus A087 vit.A 200UI in HighFatDiet vitAD+ Delage 04->15203375 2.65 62 2.6 1.0 2.7 both Rf' dmh 1x15 -4+17 114 43 4.5 1.8 3.46 3.41 vitA A088 tannin (red alder) 10mg/kg /mice phyto GaliMuht. 01->11588891 2.64 62 init Mb dmh 24x20 -1+1 tan A089 auraptene 250ppm /mice db-/- phyto+ Hayashi 07->17571970 2.63 62 5.1 1.3 3.5 both no Ml'' aom 3x10 0+10 80 31 37.5 7.3 3.66 2.75 aur A090 celecoxib+curcumin 0.16+0.6% combi+ Shpitz 06->17228149 2.62 62 2.6 post blind Rf' dmh 2x30 0+6 64 25 11.1 4.2 cel A091 hesperidin 0.1% phyto Tanaka 97->9163681 2.62 62 1.3 3.4 post blind Rf' aom 3x15 +4+32 89 34 2.77 2.22 hes A092 indomethacin 16ppm * MDF * NSAI+ Morioka 05 2.60 62 post Rf' dmh 2x40 +0+6 20 8 ind A093 indomethacin 16ppm * MDF * NSAI+ Yoshimi 04->15504245 2.60 62 3.4 post Rf' dmh 2x40 +1+8 20 8 7.5 2.2 ind A094 beet fiber in 20% lard diet fibact Kristians. 95->7644384 2.60 61 1.7 both Rw' dmh 10x20 -0+10 bee A095 FOS 6% + celecoxib .15% combi+ Buecher 03->14971826 2.59 61 2.7 1.2 3.0 both Rf' aom 2x15 -3+11 44 17 8.6 3.1 2.51 2.15 fos A096 PAF-recept.antag. 1mg/kg //TNB other+ Furihata 02->11891526 2.58 61 post Rf' dmh 04x20 +1+7 85 33 paf A097 Bifidobacterium 2E8/g fibact Abdelali 95->8584448 2.57 61 5.7 init Rs' dmh 02x25 -4+4 Bif A098 inulin 10% fibact+ Verghese 02->12221250 2.56 61 5.1 both no Rf' aom 2x16 -2+9 154 60 26.3 5.2 inu A099 selenium BSeSG 3.4ppm other Kawamori 98->9625800 2.56 61 6.0 init no Rf' aom 2x15 -1+4 133 52 18.0 3.0 sel A100 Butyrivibrio fibrisolvens 10E9x3/wk fibact+ Ohkawara 05->16317136 2.55 61 3.3 1.1 2.7 both Mi' dmh 2x30 -1+3 24 9 1.3 0.4 1.29 1.22 B.fi A101 CLA 9t,11t-conjug.linoleic.ac. 0.1% fat+ Yasui 07->17927506 2.53 60 28 2.0 5.0 both Rf' aom 2x20 -1+3 101 40 33.6 1.2 3.02 1.52 CLA dubious large ACF data A102 calcium .75vs.25%+vit.D3 20ng/kg combi+ Molck 02->12183071 2.52 60 4.0 both Rf' aom 2x15 -3+17 88 35 5.6 1.4 cal+vitD A103 cannabinoid.r.agon. HU210 0.1mg/kg other+ Izzo Aviel. 08->17823781 2.51 60 11 both Mc'' aom 6x3 0+26? 13 5 0.6 0.1 can A104 lactosylCeramide 250ppm/mice other Schmelz 00->10702579 2.50 60 post Mf'' dmh 30x6 +1+5 25 10 lac A105 onion (dried) 5% /IQ phyto+ Tache 07->17188859 2.49 60 11 1.5 3.7 init blind Rf'' iq 2x200 -2+0 2 1 0.1 0.0 1.97 1.33 oni A106 rotenone 500ppm phyto+ Yoshitani 01->11604990 2.49 60 1.5 1.2 2.9 init Rf' aom 2x20 -1+3 120 48 15.0 10.0 2.55 2.17 rot A107 indole3carbinol 0.1% //IQ phyto Xu 96->968706244 2.46 59 1.1 2.7 init Rf' iq 07x50 -2+4 ind A108 tea 1.25% + milk 1.85% phyto Weisburg. 97->9103322 2.45 59 1.6 init Rf' aom 2x15 -1+1 41 17 7.0 4.3 tea A109 rutin 4% phyto+ Wijnands 04->15304309 2.42 59 2.6 1.1 2.6 post Rf' aom 3x15 -1+7 46 19 21.0 8.0 3.40 3.16 no effect at 15 & 26wks A110 citrus unshiu 0.5% /mice db-/- phyto+ Suzuki 06->17066427 2.41 59 4.6 1.5 3.6 post no Ml'' aom 5x15 +1+8 147 61 76.6 16.8 4.44 2.95 cus A111 WR151327 0.5% other Wargovich 00->10837003 2.40 58 init blind Rf' aom 2x15 -1+5 wr1 A112 wheat germ extr. ferment. 3g/kg phyto+ Zalatnai 01->11577004 2.39 58 both Rf' aom 3x15 -2+30 5 2 whe A113 oltipraz 200ppm phyto+ Sivananthan 05 2.38 58 1.0 post Rs aom 2x15 +1+11 100 42 1.00 1.00 olt A114 retinoid acyclic vitAD+ Suzui 05 2.38 58 both Rf' dmh 2x40 -1+4 100 42 acr A115 quercetin 2% phyto Matsuka. 97->9075782 2.38 58 3.4 init Rf'' aom 3x8 -0+5? 67 28 16.5 4.8 que A116 methionine restr. 0.17% vs.0.86% other+ Komninou 06->16898864 2.38 58 26 both no Rf' aom 2x15 -1+11 373 157 13.0 0.5 met A117 CAI imidazole 200ppm other Wargovich 00->10837003 2.37 58 init blind Rf' aom 2x15 -1+5 cai A118 aceglatone 2% phyto Yoshimi 01 2.36 58 5.0 init Rf aom 2x15 -1+5? ace A119 retinamide 2-CPR 1mol/g vitAD Zheng 97->9395211 2.35 57 1.5 init Rf' aom 2x15 -1+5 54 23 5.9 4.0 ret A120 pterostilbene 40ppm (blueberry) phyto+ Suh Paul 07->17200374 2.33 57 1.4 post Rf' aom 2x15 +1+9 273 117 35.6 25.1 pte A121 diallyl sulfide 0.2% phyto Wargovich 96->9162301 2.33 57 init blind Rf' aom 2x15 -1+5 dia A122 rice-germ 2.5% phyto Kawabata 99->10545413 2.33 57 1.1 2.6 init Rf' aom 3x15 -1+4 93 40 2.10 1.85 ric A123 curcumin 0.2% phyto Rao Simi 93->8242846 2.32 57 4.4 1.0 2.3 both blind Rf' aom 2x15 -2+9 123 53 46.5 10.5 2.69 2.69 cur A124 NOS inhibit. PBIT 50ppm /N Rao Kaw. 99->10223193 2.30 57 4.6 both blind Rf' aom 2x15 -2+10 113 49 23.0 5.0 nos A125 indole3carbinol 100ppm phyto+ Kim DH 03->12628507 2.28 56 1.3 2.9 post Mc' aom 4x5 +3+36 23 10 2.30 1.80 i3c A126 auraptene 500ppm phyto Tanaka 97->9395216 2.28 56 1.3 3.0 post blind Rf' aom 3x15 +4+32 157 69 2.91 2.19 aur A127 sulindac sulfoxide 160ppm NSAI Wargovich 00->10837003 2.27 56 2.0 post blind Rf' aom 2x15 +4+8 sul A128 ursodeoxycholic acid 0.4% other Seraj 97->9097984 2.24 55 4.2 1.3 2.9 both Rf' aom 2x15 -1+8 130 58 34.0 8.0 2.80 2.10 urs A129 ketyoprofen 200ppm NSAI Wargovich 00->10837003 2.24 55 post blind Rf' aom 2x15 +4+8 ket A130 ursodeoxycholic acid 0.4% other+ Wali 02->12433708 2.24 55 4.7 init Rf' aom 2x20 -1+1 32 63 28 14.0 3.0 urs A131 D609 150ppm NSAI Wargovich 00->10837003 2.23 55 init blind Rf' aom 2x15 -1+5 d60 A132 selenite 2mg/kg //DMABP ! other Feng 99->10329505 2.22 55 1.0 2.2 both Rf' dmabp2x99 -4+8 5 2 1.95 2.05 sel A133 piroxicam 75ppm NSAI Wargovich 96->9162301 2.22 55 init blind Rf' aom 2x15 -1+5 pir A134 tocopherol mix Gamma 0.1% vitAD+ Newmark 06->17176221 2.22 55 1.0 post Rf' aom 2x15 +0+8 273 123 10.0 10.0 toc A135 curcumin 0.6% phyto+ Kwon 02 2.21 55 2.2 both Rs' aom 2x15 -1+14 77 35 76.7 34.7 cur A136 nobiletin 500ppm phyto Kohno 01->11488403 2.21 55 1.9 1.2 2.6 init no Rf' aom 3x15 -1+2 nob A137 indole-3-carbinol 1.4mm * MDF * phyto+ Plate 06->16113056 2.20 54 both Rw' aom 2x15 -2+8 3 1 I3C A138 selenium broccoli 1ppm //DMABP ! phyto Finley 00->10958840 2.19 54 1.0 2.3 both Rf' dmabp2x99 -3+8 5 2 2.06 2.00 sel A139 diclofenac 130ppm NSAI Wargovich 00->10837003 2.18 54 post blind Rf' aom 2x15 +4+8 dic A140 s-allylcysteine 80%MTD phyto Hatono 96->8640910 2.17 54 init R aom all A141 sphingomyelin 500ppm other Dillehay 94->8169652 2.17 54 ? Mf'' dmh 30x6 +1+5 13 6 sph A142 beer (Munich) 100% drink phyto+ Nozawa 04->14648707 2.17 54 3.8 1.1 2.4 both Rf' aom 2x15 -1+5 146 67 18.0 4.8 2.30 2.10 bee A143 pleuran B-glucan 10% vs 0 fibre fibact+ Bobek 01->11575739 2.16 54 1.1 post Rs' dmh 03x20 +0+8 42 20 0.3 0.3 ple A144 lycopene 75ppm phyto Wargovich 00->10837003 2.16 54 init blind Rf' aom 2x15 -1+5 lyc A145 protocatechuic ac. 0.1% phyto Kawamori 94->8071110 2.16 54 1.2 0.8 1.7 init no Rf' aom 3x15 -1+4 149 69 13.0 11.0 1.40 1.66 pro A146 synbiotics FosLacBif 10% * MDF fibact+ Caderni 03->12750256 2.16 54 1.9 4.1 both blind Rf' aom 2x15 -1+15 8 4 12.20 6.40 syn A147 beer freeze-dried 1% phyto+ Nozawa 04->15066585 2.15 54 1.5 3.2 both Rf' phip 10x75 -1+4 8 4 2.10 1.40 bee A148 vaccination PSK other Matsunag 00->11142416 2.15 53 1.0 2.2 init Rf' aom 3x15 -7 176 82 1.92 1.80 vac A149 s-allylcysteine 250ppm phyto Wargovich 00->10837003 2.15 53 1.1 2.4 init blind Rf' aom 2x15 -1+5 s-a A150 retinamide 4-HPR 782ppm vitAD Zheng 99->10069462 2.15 53 init Rf' aom 2x15 -1+2 ret A151 Bifidobacterium longum lyoph 3% fibact Kulkarni 94->7800683 2.15 53 1.7 0.9 1.9 init Rf' aom 2x20 -5+6 101 47 19.0 11.0 2.46 2.76 Bif A152 fat low- 5% vs 20% corn oil fat+ Liu 01->11605002 2.14 53 1.1 2.3 post Rs' dmh 02x20 +0+4 79 37 1.94 1.76 fat A153 arginine 0.5% /N Wargovich 96->9162301 2.13 53 init blind Rf' aom 2x15 -1+5 arg A154 pectin citrus 15% fibact AviviG 00->11132927 2.12 53 1.0 2.1 both Rr' dmh 05x40 -0+10 pec A155 calcium 1.5 vs 0.5% high-Fe diet miner+ Liu 01->11410805 2.12 53 1.1 2.4 init Rw' dmh 01x20 -1+4 55 26 1.85 1.62 cal A156 sulindac 320ppm NSAI Rao New. 98->9498278 2.11 53 1.8 both blind Rf' aom 2x15 -2+9 114 54 29.0 16.0 sul A157 retinoic 13cisRet 390ppm vitAD Wargovich 00->10837003 2.11 53 post blind Rf' aom 2x15 +4+8 ret A158 cress (garden) 5%/water //IQ ! phyto+ Kassie 02->12117773 2.09 52 2.3 0.8 1.7 init Rf' iq 10x100 -4+16 8 4 2.3 1.0 2.39 2.88 cre A159 glucarate calcium 5% phyto Wargovich 00->10837003 2.09 52 post blind Rf' aom 2x15 +4+8 glu A160 oleanolic acid 1500ppm phyto+ Janakiram 08->18408893 2.08 52 2.3 both blind Rf' aom 2x15 -1+7 90 43 16.1 7.0 ole A161 Miso 20% phyto Masaoka 98->9824853 2.08 52 0.9 1.9 init Rf' aom 3x15 -1+2 Mis A162 curcumin 0.8% =40% MTD phyto+ Volate 05->15831530 2.07 52 1.8 both Rf' aom 2x15 -1+4 184 89 28.0 16.0 cur A163 Brussels sprouts juice 5% //IQ phyto+ Kassie 03->12584175 2.06 51 1.1 2.2 init Rf' iq 10x100 -1+1 10 5 1.45 1.38 bru A164 copper 5 vs 0.8ægCu/g //DMABP miner Davis 99->10222400 2.05 51 both Rf' dmabp2x99 -3+8 cop A165 arctiin 200ppm //PhIP phyto Hirose 00->10814883 2.05 51 2.5 1.0 2.1 init Rf' phip 8x99 -1+40 arc A166 glucosylceramide soy 0.1% /mice fat+ Symolon 04->15113963 2.05 51 1.0 2.0 post Mf'' dmh 6x30 +1+5 30 14 1.20 1.20 cer A167 ibuprofen 400ppm NSAI Wargovich 96->9162301 2.04 51 init blind Rf' aom 2x15 -1+5 ibu A168 retinoic 9cisRet 390ppm vitAD Wargovich 00->10837003 2.03 51 init blind Rf' aom 2x15 -1+5 ret A169 apple procyanidins 0.01% water phyto+ Gosse 05->15790589 2.02 51 post Rw' aom 2x15 +1+6 91 45 app A170 lycopene 0.12 mg/d //MNU phyto Narisawa 96->8913278 2.02 50 2.2 post Rs'' mnu 3x40 +2+5 lyc A171 selenium broccoli 2ppm phyto Finley 01->11368655 2.01 50 both Rf' dmh 02x25 -3+8 137 68 sel A172 Mg(OH)2 1% PEG+ Tache 06->16716974 2.01 50 4.7 1.2 2.3 post blind Rf aom 1x20 +1+5 96 48 9.3 2.0 2.09 1.80 mgo K5 st. A173 Bacillus polyfermenticus 3.10E8/d fibact+ Park Jeon 07->17329858 2.01 50 0.90 1.0 both no Rf' dmh 6x30 -1+9 138 68 27.0 31.0 2.06 2.04 bac AC(not ACF) A174 apigenin 0.1% phyto+ Au Li 06->16898869 2.00 50 1.1 2.2 post blind Mf'' aom 1x5 +1+7 7 3 1.20 1.10 api A175 fish oil 8% vs corn oil fat Latham 99->10223194 2.00 50 2.2 init Rw' dmh 03x20 +1d 26 13 5.5 2.5 fis A176 calcium .5%+aspirin 200ppm/mice combi+ Liu-Ju 06 2.00 50 4.8 post Mf'' aom 2x10 +0+8 100 50 20.0 4.2 asp+ca A177 probiotic SCM-III LactBif 2ml/d !! fibact+ Marotta 03->14696432 2.00 50 1.2 2.5 init Rs' aom 10x15 ?+3 116 58 2.20 1.60 strange A178 EGF-recept.relat.prot. .5mg/mice other+ Schmelz 06 2.00 50 1.7 3.3 post Mf dmh 6x30 +0+1.5 100 50 2.00 1.20 errp A179 retinoic 13cis 780ppm vitAD Wargovich 95->7829266 2.00 50 1.9 post blind Rf' aom 2x15 +4+8 140 70 57.0 30.0 ret A180 B-escin 500ppm phyto+ Patlolla 06->16818504 2.00 50 2.8 both blind Rf' aom 2x15 -1+9 160 80 29.6 10.4 esc A181 ursodeoxycholic ac. 1mg/d colost. other+ Lin 01->11431100 1.99 50 2.7 1.0 2.0 post Rf' aom 2x15 +0+4 174 87 2.7 1.0 1.10 1.10 urs A182 Brussels sprouts juice 5% //IQ phyto+ Uhl 04->15036015 1.98 49 1.1 2.1 post Rf' iq 10x100 +0+3 10 5 1.45 1.38 bru A183 curcumin 0.2% phyto Rao Cooma 01 1.97 49 post blind Rf' aom 2x15 +3d+8 cur A184 fish oil 17% vs 20% lipid mix fat Rao Hirose 01->11280748 1.96 49 2.8 post blind Rf' aom 2x15 -2+8 fis A185 retinamide 4-MPR 1mol/g vitAD Zheng 97->9395211 1.96 49 init Rf' aom 2x15 -1+5 ret A186 folate deficiency vs 2ppm vitB+ Geter 05->15921841 1.94 49 2.1 1.1 2.1 both Rf' aom 1x15 +0+26 70 36 37.7 17.8 5.54 5.16 fol A187 garlic, aged extract AGE 4% phyto+ Katsuki 06->16484578 1.94 48 2.1 both no Rs' dmh 20x20 -1+25 273 141 29.0 13.7 age A188 vit. A 27 UI/g vs.7.5 UI/g fat+ Delage 05->15856452 1.94 48 2.7 both blind Rw' dmh 1x15 -4+4 192 99 17.3 6.5 vitA HF diet A189 Bifidobacter. + lactulose fibact Challa 97->9067551 1.93 48 1.1 2.1 both Rf' aom 2x16 -1+9 187 97 2.10 2.01 Bif A190 calcium 0.5% vs 0.1% miner Thiagaraj. 98->9848506 1.93 48 1.9 post Rf' aom 2x15 +1+13 133 69 93.0 48.0 cal A191 ethoxyquin 0.16% other+ Patlolla6 06 1.92 48 2.2 both Rf' aom 2x15 -1+7 100 52 20.0 9.0 eth A192 inulin 5% fibact+ Bolognani 01->11876494 1.92 48 1.3 post no Rs' aom 2x12 +1+5 173 90 53.0 40.0 inu HF diet A193 olive oil 5% vs safflower oil fat+ Bartoli 00->10644312 1.91 48 2.7 1.0 2.0 init Rs' aom 11x7.4 +12 21 11 7.1 2.6 2.07 2.00 oli A194 resveratrol 20ppm phyto+ Kineman 07->17571969 1.91 48 1.2 2.2 post blind Mf'' aom 1x5 +1+6 8 4 1.50 1.30 res A195 ONO-1714 100ppm /N+ Takahashi->16122953 1.90 47 2.8 1.1 2.1 both Rf' aom 2x15 -0+3 237 125 25.2 8.9 2.15 1.99 clear dose-effect A196 Ginkgo biloba extract 500ppm phyto+ Suzuki 04->15183531 1.89 47 12 1.2 2.3 both Rf' aom 2x20 -1+2 106 56 9.8 0.8 2.07 1.67 gin A197 polyamine low- diet /N Duranton 97->9044827 1.89 47 post Rw' dmh 12x20 low A198 dehydroepiandrosterone 0.5% other Pereira 91->1837244 1.88 47 1.1 2.1 init no Rs' aom 2x15 -1+4 228 121 0.1 0.1 2.59 2.44 deh A199 oxothiazolidine carboxylate ?% other Pereira 91->1837244 1.88 47 1.1 2.1 init no Rs' aom 2x15 -1+4 228 121 0.1 0.1 2.59 2.38 oxo A200 Coptidis rhizoma extr 2% phyto Fukutake 98->9743248 1.88 47 1.0 1.9 init Rf' aom 2x15 -0+4 137 73 1.69 1.48 Cop A201 lactoferrin (bovine) 2% other+ Sekine 97->9570361 1.87 47 3.3 1.0 1.9 both Rf' aom 2x15 -0+4 222 119 18.0 5.5 2.02 1.94 lfb A202 S-adenosyl-L-methionine 800ppm other+ Guruswamy 08->17724725 1.87 46 2.4 both blind Rf' aom 2x15 -1+7 98 53 19.0 8.0 sam A203 zerumbone 500ppm phyto Tanaka 01->11693274 1.87 46 16 1.3 2.4 init blind Rf' aom 3x15 -1+2 zer A204 B-carotene 90ppm phyto Shivapu. 95->7834797 1.85 46 1.6 post Rf aom 2x15 +6+18 107 58 54.0 34.0 B-c A205 nitroflavone 4'-OH-3- 125ppm other+ Steele 02->12438244 1.84 46 init Rf aom 2x15 -1+4 94 51 3NF A206 starch resist.III 20% vs normal fibact Perrin 01->11115823 1.84 46 1.1 2.0 init Rb'' aom 2x15 -6+4 sta A207 squalene 1% fat Rao New. 98->9498278 1.84 46 1.7 both blind Rf' aom 2x15 -2+9 114 62 29.0 17.0 squ A208 xanthine.oxid.Y-700 20ppm /mice other+ Hashimoto 05->15665488 1.84 46 both Md' dmh 3x10 +0+10 10 6 xan A209 ceramide (monoglucosyl) 200ppm fat+ Inamine 05->16367907 1.84 46 1.9 both Rf' dmh 2x40 -1+3 197 107 10.4 5.4 no dose-effect A210 ceramide 200ppm * BCAC * fat+ Inamine 05->16367907 1.84 46 1.9 both Rf' dmh 2x40 -1+3 1 0 no dose-effect A211 lupulone 50ppm phyto+ Lamy 07->17434926 1.83 45 2.4 post no Rw' aom 2x15 +1+28 73 40 43.6 17.9 lup A212 chrysin 100ppm phyto+ Miyamoto 06->16596181 1.83 45 5.0 1.1 2.1 both no Rf' aom 2x20 -1+3 73 40 9.9 2.0 1.98 1.73 chr A213 saline infusion in colon 2x.5ml/d fibact+ Wong 05->15711862 1.83 45 both Rs' aom 2x15 -2+3 9 5 wat A214 tryptanthrin 50mg/Kg phyto+ KoyaMiyata 01->11848486 1.82 45 0.9 1.7 init Rf'' aom 3x15 -0+4 9 5 3.27 3.55 try A215 vit. D 24R.25-diOH 10ppm vitAD Taniyama 00->10657954 1.81 45 1.7 post Rf' dmh 04x20 +5+12 372 206 94.4 55.5 vit A216 starch resistant High RS 30%vs.0 fibact+ Liu Xu 08->18571825 1.81 45 1.9 0.9 1.7 post Rw' aom 2x15 0+3? 65 36 15.0 8.0 2.28 2.43 RS promot before aom A217 Bifidobacter. + Neosugar 5% fibact Koo 91->1775387 1.80 45 1.0 1.8 both Mf'' dmh 06x20 -2+38 Bif A218 auraptene 500ppm phyto Tanaka 98->9635577 1.80 44 1.4 2.5 post blind Rf' aom 3x15 +4+38 90 50 2.94 2.06 aur A219 calcium carbonate 1.6% miner Pereira 94->8200067 1.79 44 1.1 init no Rf' aom 2x15 -1+4 cal A220 inulin 10% fibact+ Buddington 02->11880573 1.78 44 both M6'' dmh 06x20 -6+10 8 5 inu A221 PGE KO mice EP4-/- NSAI+ Mutoh 02->11782353 1.78 44 1.0 1.8 both Mc' aom 3x10 15 8 1.50 1.50 pge A222 capsanthin 0.2mg/d phyto Narisawa 00->10806419 1.78 44 1.8 post Rf'' mnu +2+6 48 28 7.3 4.0 cap A223 indomethacin 2mg/kg NSAI Charal. 96->8672749 1.77 44 1.0 1.8 both Rs dmh 02x25 -0+3 197 111 ind A224 indole-3-carbinol 1.4mmol/kg phyto+ Plate 06->16113056 1.76 43 1.3 0.9 1.6 both Rw' aom 2x15 -2+8 10 6 1.2 0.9 2.08 2.32 I3C A225 chlorogenic acid 250ppm * BCAC phyto+ Morioka 04->15036645 1.76 43 both Rf' aom 2x20 -1+3 2 1 chl A226 chlorogenic acid 250ppm phyto+ Morioka 04->15036645 1.76 43 11 both Rf' aom 2x20 -1+3 94 53 10.8 1.0 chl A227 selenium 2ppm other+ Irons 06 ->16614422 1.75 43 1.0 1.8 both blind Mv aom 4x10 -3+12 23 13 2.19 2.10 sel A228 butyrate infusion 80mM 5x1ml/d fibact+ Wong 05->15711862 1.75 43 both Rs' aom 2x15 -2+3 5 3 but A229 aspirin 200ppm NSAI Wargovich 95->7829266 1.75 43 2.7 post blind Rf' aom 2x15 +4+8 175 100 55.0 20.0 asp A230 starch amylose+Clostr.butyr.20% fibact+ Nakanishi 03->14695445 1.74 43 0.9 1.6 both no Rf' aom 2x15 -1+6 94 54 2.00 2.20 sta A231 lemon grass extract 5g/kg phyto Suaeyun 97->9163680 1.74 42 1.7 1.0 1.7 post Rf' aom 2x15 +2+12 193 111 99.0 58.0 3.90 3.80 lem A232 onion (dried) 5% phyto+ Tache 07->17188859 1.74 42 2.5 1.1 2.0 post blind Rf'' aom 1x20 +1+15 59 34 15.0 6.0 2.70 2.40 oni A233 vaccination K-ras peptides other+ Paulsen 02->12017282 1.73 42 1.1 1.9 both Rf' aom 2x15 -3+13 166 96 2.59 2.30 vac A234 genistein 150ppm phyto Thiagaraj. 98->9848506 1.73 42 2.3 post Rf' aom 2x15 +1+13 133 77 93.0 41.0 gen A235 PEG 8000 5% PEG+ Karlsson 05->15896454 1.72 42 2.0 post Rf' aom 2x15 +1+9 234 136 12.1 6.1 peg A236 almond 19% phyto+ Davis 01->11248415 1.72 42 both Rf' aom 2x15 -5+21 86 50 alm A237 lutein 0.12mg/d //MNU phyto Narisawa 96->8913278 1.72 42 1.4 post Rs'' mnu 3x40 +2+5 lut A238 diosgenin 0.1% phyto+ Raju 04 1.72 42 1.6 both blind Rf' aom 2x15 -1+8 fenugreek A239 diogesmin 0.1% phyto+ Raju 04->15298963 1.72 42 1.5 both blind Rf' aom 2x15 -1+8 176 102 24.0 15.6 dio A240 soy isoflavones 0.1% phyto+ Sung 08->18361741 1.72 42 post no Rs' dmh 4x20 +0+12 225 131 iso A241 limonin 200ppm (grapefruit) phyto+ Vanamala 06->16387741 1.71 42 30 both no Rs' aom 2x15 -3+7 185 108 13.9 0.5 lim A242 curcumin 0.2% phyto Rao Kaw. 99->10223193 99 1.71 42 1.6 both blind Rf' aom 2x15 -2+10 113 66 23.0 14.0 cur A243 geranyl EGMP 0,2% other Han 01->11346462 1.71 41 2.1 1.0 1.7 post Rf' aom 2x15 +1+4 ger A244 sulindac 320ppm NSAI Pereira 94->8200067 1.70 41 1.1 1.9 init no Rf' aom 2x15 -1+4 26 15 0.0 0.1 2.04 1.82 sul A245 glucarate calcium 5% phyto Pereira 94->8200067 1.69 41 0.9 init no Rf' aom 2x15 -1+4 glu A246 celecoxib 0.15% NSAI Reddy 96->8840961 1.69 41 1.9 both blind Rf' aom 2x15 -2+9 120 71 35.0 18.0 cel A247 reovirus 5x10E9/wk other+ Alain 07->17627293 1.69 41 3.6 post blind Rs'' aom 4x15 +20+24 490 290 9.1 2.5 reo A248 sinigrin 400ppm phyto Smith 98->9498275 1.69 41 0.9 1.5 post Rw' dmh 02x30 +0+6 25 15 2.10 2.33 sin A249 tea green (2% as drink) phyto Jia 01->11759287 1.69 41 2.0 both Rw' dmh 10x20 -0+16 250 148 24.6 12.5 tea A250 acetoxychavicol acet. 100ppm phyto Tanaka 97->9163704 1.69 41 3.2 1.1 1.9 post blind Rf' aom 3x15 +4+32 118 70 32.0 10.0 2.54 2.24 ace A251 butylhydroxyanisole 0.4% other Lam 91->1747933 1.68 40 1.1 1.8 init Mf'' dmh 02x4 -1h but A252 fat low- 5% vs 20% lipid mix fat Rao Hirose 01->11280748 1.68 40 2.3 post blind Rf' aom 2x15 -2+8 low A253 indole3carbinol 0.2% phyto+ Stoner 02->11872631 1.68 40 1.5 post Rs'' aom 2x15 +4+28 285 170 167.0 113.0 ind A254 mangiferin 0,1% phyto Yoshimi 01->11165750 1.68 40 2.1 1.1 1.8 init Rf' aom 3x15 -1+3 man A255 fish oil+cell.10+10% vs sunfl.+RS fat+ Coleman 02->12163681 1.67 40 1.6 both R aom 2x15 -4+9 226 135 64.0 40.0 fis A256 garcinol 500ppm phyto Tanaka 00->10837008 1.67 40 2.8 1.1 1.8 init blind Rf' aom 3x15 -0+5 97 58 6.3 2.2 2.25 2.07 gar A257 calcium 0.3g/d in whole bread miner Wargovich 01 1.67 40 2.0 post blind Rf aom 2x15 +4+8? cal A258 hop extr. (isomerized) 500ppm phyto+ Nozawa 05->15968705 1.67 40 2.7 1.1 1.8 both Rf' aom 2x15 -1+4 77 46 8.1 3.0 2.27 2.15 ihe A259 starch resistant Low RS 0%vs.30 fibact+ Liu Xu 08->18571825 1.66 40 1.5 1.1 1.8 init Rw' aom 2x15 -3-0? 108 65 22.0 15.0 2.45 2.28 RS protect after aom A260 mofezolac COX1 0.12% NSAI+ Kitamura 02->12189188 1.65 40 1.0 1.6 init Rf' aom 2x15 -0+4 182 110 2.00 2.10 mof A261 mofezolac cox1 1200ppm NSAI+ Kitamura 03->12189188 1.65 40 1.0 both Rf' aom 2x15 -0+3 182 110 2.00 2.10 mof A262 5ASA aminosalicylic ac. 20mg/kg NSAI+ Brown 00->11007109 1.65 39 post Rs' dmh 02x25 +0+3 218 132 5-a A263 chlorophyllin 0.1% //PhIP phyto Guo 95->8603466 1.65 39 4.7 1.6 2.6 both Rf' phip 7x50 -2+16 chl A264 adlay (Coix lachryma-jobi) 10% phyto+ Shih 04->15207385 1.65 39 1.6 1.0 1.7 both Rf' aom 2x20 -1+4 66 40 11.0 7.0 1.77 1.73 no dose-effect A265 nitroflavone 4'-OH-3- 125ppm other+ Steele 02->12438244 1.65 39 post Rf aom 2x15 +3+7 132 80 3NF A266 quercetin 0.1% phyto+ Gee 02->12599752 1.63 38 1.8 1.1 1.7 post Rw' dmh 02x? +0+6 91 56 20.4 11.6 2.55 2.39 que A267 piroxicam 125ppm NSAI Pereira 94->8200067 1.63 38 1.1 1.8 init no Rf' aom 2x15 -1+4 26 16 0.0 0.1 2.04 1.84 pir A268 pectin 10% fibact Rao Chou 98->9806164 1.62 38 2.7 1.1 1.8 both blind Rf' aom 2x15 -2+8 pec A269 wheat bran 10 vs 20%res.starch fibact Young 96->8566598 1.62 38 init Rs dmh 10x20 -1+6 whe A270 polydextrose 3% fibact+ Ishizuka 03 1.62 38 1.2 1.9 both Rw' dmh 01x30 -1+5 42 26 1.59 1.38 pol A271 B-ionone 0.1% (carotenoid) phyto+ Janakiram 08->18202021 1.61 38 2.3 both blind Rf' aom 2x15 -1+9 99 61 17.6 7.6 ion A272 docosahexaenoic 0.7ml/d fat Takahashi 97->9230276 1.61 38 2.0 1.1 1.8 init Rf' aom 2x15 -0h 308 191 114.0 56.0 3.20 2.95 doc A273 lactoferrin (bovine) 2% other+ Fujita 04->15312680 1.61 38 post Rf' aom 3x15 +1+10 436 271 lfb A274 wheat diet unrefined //IQ fibact Yu 01->11397513 1.61 38 1.2 1.1 1.8 post Rf' iq 07x133 +1+12 whe A275 butyltiophene 100ppm other Wargovich 00->10837003 1.60 38 0.9 1.4 init blind Rf' aom 2x15 -1+5 but A276 Centella asiatica extr. 100mg/kg phyto+ Bunpo 04->15500935 1.60 37 1.8 1.0 1.7 post Rf' aom 2x15 +2+14 364 228 131.0 74.7 3.15 3.03 cen A277 isoliquiritigenin 15ppm /mice phyto+ Baba 02->11853176 1.59 37 1.0 1.5 both My' aom 2x10 +0+4 72 45 1.47 1.54 licorice A278 troglitazone 1000ppm Ppar-G Ppar+ Osawa 03->12557142 1.59 37 1.2 1.9 both Mb'' aom 2x10 -1+3 15 9 1.37 1.15 Toxic+ A279 propolis extr. 30mg/kg other+ Bazo 02->11948629 1.59 37 2.1 1.1 1.7 post Rw' dmh 02x40 +0+2 45 28 1.7 0.8 1.34 1.23 pro A280 nabumetone 0.15% NSAI+ Roy 01->11304699 1.59 37 1.8 both blind Rf' aom 2x15 -2+16 293 185 8.0 4.5 nab A281 folate 2mg/kg vs 0 in Se+ diet phyto+ Davies 03->12949386 1.58 37 1.1 1.7 both Rf' dmh 02x25 -3+8 80 51 2.95 2.75 fol A282 isoloquiritigenin (from licorice) phyto+ Takahashi 04->15132774 1.58 37 1.9 1.0 1.6 both Rf' aom 3x15 -0+3 172 109 27.2 14.3 2.44 2.45 iso A283 whey protein hydrol. 20% other+ Xiao 06->16504496 1.58 37 2.1 1.1 1.7 both blind Rs' aom 2x15 -7+7 125 79 9.4 4.4 2.05 1.94 whe A284 geranyl EGMP 0.2% other Tsuda 99->10625958 1.58 37 2.0 1.1 1.7 post Rf' aom 2x15 +2+5 253 160 51.0 25.0 2.58 2.44 ger A285 B-carotene 200ppm phyto+ Raju 05->15499611 1.58 37 2.3 both blind Rf' aom 2x15 -2+7 98 62 16.0 7.0 prom./ high dose A286 Beef tallow 14% vs 14% soy oil fat+ Khil 04->15572298 1.58 37 0.9 1.4 post Rs' dmh 2x15 +1+9 3 2 3.08 3.56 fat A287 sulindac 10mg/kg NSAI Charal. 96->8672749 1.58 37 1.6 0.9 1.4 both Rs dmh 02x25 0+3 sul A288 PEG 8000 5% PEG+ Roy 04->15374630 1.58 37 2.8 post blind Rf' aom 2x20 +2+36 63 40 14.0 5.0 full data: Wali02 A289 folate 2ppm vs no folate diet vitB+ Geter 05->15921841 1.57 36 7.0 1.1 1.7 both Rf' tbm .5g/l +0+26 3 2 1.2 0.2 2.51 2.32 fol A290 starch vs sucrose bolus other Luceri 96->8710688 1.57 36 init blind Rf'' aom 1x20 -1d sta A291 allylthiopyrazine 50mg/kg phyto Kim 01->11311484 1.57 36 1.6 1.0 1.6 post Rf' aom 3x15 +1+5 all A292 bezafibrate 500ppm other Tanaka 01->11289109 1.57 36 1.1 1.7 init blind Rf' aom 2x20 -1+2 bez A293 ceramide-Bglucur. 0.1% /mice other Schmelz 99->10582697 1.56 36 1.2 1.9 post Mf'' dmh 30x6 +1+5 30 19 1.80 1.50 cer A294 raloxifene 1.25ppm other+ Rao-Janak. 06 1.56 36 1.8 both blind Rf' aom 2x15 -1+7 100 64 20.0 11.0 no dose-effect A295 docosahexaenoic+EPA 0.3% fat Paulsen 98->9527643 1.56 36 1.8 init Rf aom 2x15 -0+6 217 139 26.0 14.0 doc A296 sulindac 320ppm NSAI Reddy 96->8840961 1.56 36 1.7 both blind Rf' aom 2x15 -2+9 120 77 35.0 21.0 sul A297 PgEP1 recept. KO mice NSAI+ Watanabe 99->10537280 1.55 36 1.1 1.6 both Mc' aom 3x10 12 8 1.70 1.60 peg A298 oleanolic 200ppm phyto Kawamori 95->7882322 1.55 36 0.9 1.3 init no Rf' aom 3x15 -1+4 152 98 1.48 1.74 ole A299 PPITC 0.4% phyto Lam 91->1747933 1.54 35 1.0 1.5 init Mf'' dmh 02x4 -1h 17 11 1.14 1.06 ppi A300 nimesulide 200ppm NSAI Takahashi 96->8601574 1.54 35 1.0 1.5 init Rf' aom 2x15 -1d+4 nim A301 inulin 10% fibact Reddy 97->9230282 1.54 35 1.4 both blind Rf' aom 2x15 -2+9 120 78 56.0 39.0 inu A302 PgEP1 ant. Ono8711 0.1% NSAI+ Watanabe 99->10537280 1.54 35 1.1 1.7 init Mc' aom 3x10 -0+5 16 11 1.40 1.30 peg A303 fish oil 20% vs corn oil fat+ Dommels 03->14563399 1.54 35 0.5 0.9 1.4 both Rf' aom 2x15 -2+5 108 70 3.1 6.0 2.20 2.50 fis A304 resveratrol 200æg/kg phyto+ Tessitore 00->10910967 1.53 35 1.8 2.8 both blind Rf' aom 2x15 -1+13 39 26 4.90 2.70 res A305 thiocyanate PEITC 2æmol/d phyto Chung 00->11133820 1.53 35 1.9 post Rf' aom 2x15 +1+8 153 100 52.0 27.0 thi A306 tea extract EGCG 0.12% phyto Steele B. 99->10202390 1.53 35 init Rf' aom 2x15 -1+1? tea A307 procyanidin B2 0.05% phyto+ Nomoto 04->15456639 1.52 34 1.6 both Rf' aom 3x15 +0+5 164 108 20.2 12.9 pb2 A308 genistein 150ppm phyto Pereira 94->8200067 1.52 34 1.0 1.5 init no Rf' aom 2x15 -1+4 85 56 1.67 1.64 gen A309 genistein 150ppm phyto+ Steele P. 95->7884556 1.52 34 1.0 1.5 both Rf' aom 2x15 -1+3 85 56 1.67 1.64 gen A310 cork 5% //IQ fibact Ferguson 98->9839631 1.52 34 5.6 1.5 2.3 both Rf' iq 03x50 -5+10 50 33 14.0 2.5 cor A311 nimesulide 400ppm //dmh+dss NSAI+ Onose 06->15876482 1.51 34 4.4 post Rf' dmh 3x40 +2+19 21 14 2.2 0.5 nim A312 lactoferrin Bacteroides uniformis fibact+ Chewonarin 01 1.51 34 1.6 1.0 1.5 init Rf' aom 2x15 -1+3 290 192 36.0 23.0 2.30 2.30 lac A313 raspberries 2.5% phyto Harris 01->11962247 1.51 34 1.3 post Rf' aom 2x15 +0+9 128 85 19.1 14.9 ras A314 N-acetylcysteine 0.2% other Pereira 91->1837244 1.51 34 1.1 1.7 init no Rs' aom 2x15 -1+4 228 151 0.1 0.1 2.59 2.35 N-a A315 celecoxib 0.15% NSAI+ Yamada 01->11429049 1.50 34 1.1 1.7 both Rf' aom 3x15 -1+7 9 6 2.96 2.59 cel A316 vit. A 200UI vitAD Maziere 98->9795968 1.50 33 post Rs' dmh +1+4 368 245 vit A317 phytic acid 2%+ green tea phyto Challa 97->9364016 1.50 33 1.1 1.7 both Rf' aom 2x16 -3+10 180 120 phy A318 curcumin 0.6% inOldRats phyto+ Kwon 04->15203376 1.50 33 both Rf' aom 2x15 -1+12 78 52 mature rats no protec A319 whey protein 32% vs kang.meat other+ Belobrajdic 03->12893429 1.50 33 both Rw aom 2x15 -4+8 142 95 whe A320 canthaxantin 500ppm phyto Tanaka 95->8603470 1.50 33 1.0 1.5 post blind Rf' aom 3x15 +4+37 193 129 3.62 3.64 can A321 chlorophyll 0.1% phyto+ Guo 95->8603466 1.49 33 1.3 post R aom 2x15 +1+11 157 105 29.5 22.3 chl A322 CLA from safflower oil 1% fat+ Cheng 03->12860274 1.49 33 1.1 1.7 post Rs'' dmh 05x40 +0+34 80 54 6.20 5.50 cla A323 roselle 0.1% phyto Chewon. 99->10478827 1.49 33 1.1 1.6 both Rf' aom 2x15 -1+8 137 92 2.08 2.04 ros A324 sulforaphane 2æmol/d phyto Chung 00->11133820 1.49 33 1.7 post Rf' aom 2x15 +1+8 153 103 52.0 30.0 sul A325 limonene 0.5% in water phyto Kawamori 96->8625465 1.47 32 2.3 1.1 1.6 init no Rf' aom 3x15 -1+4 131 89 37.0 16.0 1.94 1.77 lim A326 PgEP1 ant. Ono8713 160ppm NSAI Watanabe 00->10840160 1.47 32 1.2 1.8 post Mc' aom 3x10 +2d+5 pge A327 proanthocyanidin 0.002% phyto+ Nomoto 04->15456639 1.47 32 2.0 both Rf' aom 3x15 +0+5 164 112 20.2 10.2 no effect 0.05%! A328 starch potato 67% vs mix fibact Thorup 95->8572609 1.47 32 5.2 post Rw' aom 2x15 +1+18 sta A329 lutein 500ppm phyto Kim 98->9472697 1.47 32 1.0 1.5 post M6 dmh 06x20 +5+12 63 43 1.82 1.87 lut A330 NOS inhibit. L-NAME 100ppm /N Kawamori 00->10680590 1.46 32 1.6 both no Rf' aom 2x15 0-10 282 193 82.0 50.0 nos A331 Clostridium perfr. cult 1E9/ml fibact Arimochi 97->9325162 1.46 31 1.0 1.5 init Rs' aom 2x15 -1+5 214 147 2.05 1.99 Clo A332 Ganoderma lucid. extr. 5% phyto+ Lu 02->11786919 1.45 31 0.9 1.3 post Md' dmh 10x10 +10+20 27 18 1.64 1.77 Gan A333 chafuroside (from ool.tea) 20ppm phyto+ Niho 06->16630115 1.45 31 1.0 1.4 both Rf' aom 2x15 -0+3 278 192 2.25 2.29 cha A334 COX2 inhibitor NS-398 10ppm NSAI Yoshimi 97->9439679 1.45 31 2.3 post Rf' aom 3x15 +1+5 123 85 16.0 7.0 cox A335 PGE recept.EP1 antag. 800ppm NSAI+ Kawamori 01->11911260 1.44 31 2.2 init no Rf' aom 2x15 -0+5 182 126 11.0 5.0 pge A336 phytic acid 1% phyto Jenab 98->9667748 1.44 31 post Rf' aom 1x15 +1+14 65 45 phy A337 calcium 1% vs 0.5% miner Li Kram. 98->9500189 1.44 31 2.0 init Rf' aom 2x15 -1+3 173 120 24.0 12.0 cal A338 ferulic acid 500ppm phyto+ Kawabata 00->10893437 1.44 31 init Rf' aom 3x15 -1+4 95 66 fer A339 PEG-like pluronic F68 1% PEG+ Tache 07->17188859 1.44 31 3.8 1.2 1.8 post blind Rf'' aom 1x20 +1+15 59 41 15.0 4.0 2.70 2.20 plu A340 JTE-522 COX2-inhib. 7mg/kg NSAI+ Wei 03->14643021 1.44 30 1.3 both Rf' dmh 4x20 -1+11 409 285 55.0 44.0 jte A341 Bifidobacter. + FOS 2% fibact Gallaher 99->10395626 1.43 30 1.0 1.4 post Rw' dmh 02x15 +1+3 6 4 1.61 1.68 Bif A342 olive oil 15% vs soil oil 15% fat+ Schwartz 04->15309441 1.43 30 both Rs' dmh 5x40 +9+11 80 56 sul A343 celecoxib+SC51 500+100ppm NSAI+ Rao Indran. 02->11782374 1.42 30 2.3 both blind Rf' aom 2x15 -2+9 120 84 28.9 12.6 cel A344 indomethacin 16ppm NSAI+ Morioka 05 1.42 29 post Rf' dmh 2x40 +0+6 150 106 ind A345 indomethacin 16ppm in water NSAI+ Yoshimi 04->15504245 1.42 29 1.30 post Rf' dmh 2x40 +1+8 150 106 28.3 21.7 also MDF & BCAC A346 bilberry anthocyanin-rich extr. 0.4% phyto+ Lala Malik 06->16800776 1.40 29 3.8 both no Rf' aom 1x20 -1+13 94 67 15.0 4.0 bil A347 lovastatin 50+ sulindac 80ppm combi Agarwal 99->10500066 1.39 28 1.4 both Rf' aom 2x15 -2+10 lov A348 tuna oil vs. corn oil 23.5% fat+ Kohno 00->10948340 1.39 28 1.9 1.1 1.6 both Rf' aom 3x15 -1+4 47 34 17.4 9.0 1.68 1.50 DHA+vit.D A349 folate deficiency vs 0.8% other LeLeu 00->11106096 1.38 28 1.2 both Rs' aom 3x15 -4+6 fol A350 curcuma extract phyto+ Kirana 07->12881017 1.38 27 1.4 both no Rs' aom 2x15 -2+11 266 194 108.0 78.5 cur A351 white ginseng 1% phyto Li Wanib. 00->10798218 1.37 27 1.5 post Rf' dmh 04x20 +4+12 305 223 37.0 25.0 whi A352 curcumin tetraHydro 0.5% phyto Kim Araki 98->9472697 1.36 26 1.0 1.4 post M6 dmh 06x20 +5+12 cur A353 cumin oil 0.2g/kg phyto+ Salim Fuku. 03->12881014 1.35 26 1.6 post Rf' dmh 03x20 +0+8 401 296 33.0 21.0 cum A354 PEG 3350 5% PEG+ Do Barnard 05->16047477 1.35 26 1.6 post Rf aom 3x20 +1+18 190 141 95.0 58.0 peg A355 PEG 3350 5% PEG+ Do-Barnard 03 1.35 26 1.6 ? Rf aom 3-4x20 ?+18 190 141 95.0 58.0 peg A356 olive oil 10% vs. Chow fat+ Fujise 07->17194898 1.34 25 1.6 both no Rs' aom 2x15 +0+12 131 98 67.0 41.0 oli ?? A357 Bifidobacterium longum 3% fibact+ Sekine 97->9570361 1.34 25 1.3 0.9 1.3 both Rf' aom 2x15 -0+4 222 166 18.0 14.3 2.02 2.15 bif A358 aminoguanidine iNOS inhib. 0.2% /N+ Rao Indran. 02->11782374 1.34 25 2.0 both blind Rf' aom 2x15 -2+9 120 90 28.9 14.6 ami A359 vit. D3 10ppm vitAD Salim 97->9439680 1.31 24 2.8 post Rf' dmh 04x20 +1+8 352 269 48.0 17.0 vit A360 leptin 1mg/kg/d other+ Aparicio 04->14762787 1.30 23 1.3 both Rf' aom 2x15 +0+3 167 128 0.3 0.2 lep A361 ursodeoxycholic acid 0.4% other Ikegami 98->10025872 1.30 23 1.0 1.3 both Rf' aom 2x15 -2+12 162 125 3.08 3.19 urs A362 tea green, extract 0.6% drink phyto+ Ju J 03->14690793 1.30 23 1.6 1.0 1.3 post Mf'' aom 2x9 +2+12 24 18 3.9 2.4 2.20 2.17 tea A363 Lactobac. casei 2.10E10/d fibact+ Yamazaki 00->10948325 1.28 22 1.9 both no Rs' aom 5x15 0+8 83 65 15.0 8.0 lac A364 Zingiber arom. extr. 4% phyto+ Kirana 03->12881017 1.28 22 1.7 both Rs' aom 2x15 -2+10 268 210 23.7 14.0 zin A365 wheat bran 25% vs 5% cell. fibact Jenab 98->9667748 1.27 22 1.0 1.3 post Rf' aom 1x15 +1+14 65 51 whe A366 apple juice (cloudy, as drink) phyto+ Barth 05->15802299 1.23 19 2.0 1.1 1.4 both Rf' dmh 4x20 -1+6 227 185 37.4 18.8 2.31 2.04 app A367 lean Fa/Fa vs obese fa/fa Zucker other+ Raju 03->14583451 1.23 19 3.7 both blind Rz'' aom 2x10 -8+8 93 76 30.8 8.4 lea A368 resveratrol 0.2% phyto+ Steele 98 1.23 18 1.4 post Rf aom 2x15 +3+7 201 164 59.0 42.0 res A369 fat low- 7% vs 22% fat Moroto. 97->8970188 1.22 18 2.3 1.1 1.3 init Rf' aom 2x15 -1+5 low A370 AIN93G diet vs AIN76A other+ Woods 02 1.22 18 init Rf' aom 2x15 -?+4 100 82 AIN A371 vegetab.juice (lycopene) =drink phyto Arimochi 99->10462473 1.22 18 1.9 1.1 1.3 init Rf' aom 2x15 -1+5 212 174 23.0 12.0 2.22 2.11 veg A372 carrots (falcarinol) 10% freez.drd phyto+ Kobaek 05->15740080 1.21 17 1.6 both Rb' aom 4x15 -1+17 186 154 21.0 13.0 car A373 flaxseed 5% phyto Jenab 96->8681453 1.20 16 1.9 1.1 1.3 both Rs' aom 1x15 -1+14 103 86 32.5 17.5 3.03 2.86 fla A374 phytate 2% phyto Pretlow 92->1394832 1.19 16 1.8 post Rf' aom 1x30 +1+12 50 42 phy A375 sphingomyelin 35mg/kg/d fat+ Exon 03->12615120 1.18 15 1.4 post Rs' aom 1x10 +6+12 168 143 34.9 24.1 sph A376 butyrate pellets 150mg/d fibact Caderni 98->9631487 1.17 15 1.6 1.0 1.2 post blind Rf' aom 2x15 +1+11 but A377 vit.E 0.2% aToco.Suc.inOldRats vitAD+ Exon 04->15456638 1.17 14 3.2 both Rs'' aom 2x10 -1+6 84 72 7.3 2.3 protects old rats only A378 selenomethionine 2ppm other Baines 00->11053649 1.17 14 2.2 post Rf' aom 2x15 +0+16 sel A379 galacto-oligosaccharides 20% fibact Wijnands 01->11159750 1.12 11 1.3 1.1 1.2 init Rf' aom 2x15 -2+4 gos A380 starch(corn) vs sucrose 34% //IQ other+ Lindecrona 04->15145517 1.09 8 2.9 both Rf' iq 200ppm -1+25 8 7 2.5 0.9 sta A381 lycopene 10ppm phyto Jain-Agarw. 99 1.07 7 1.0 1.1 both Rf' aom 1x15 -1+14 260 242 50.0 45.0 2.36 2.43 lyc A382 peas 10% phyto Rijken 99->10590218 1.03 3 2.1 1.2 1.2 both Rs' aom 2x15 -12+14 152 148 35.0 17.0 2.60 2.10 pea A383 rye bran 30% vs 9% cellulose phyto+ Davies 99->10357769 0.88 -14 1.2 both Rf' aom 2x15 -1+12 125 142 19.0 15.6 rye A bilberry 3.5ppm anthocyanin phyto+ Lala 06->16800776 1.40 29 3.7 no Rf' aom 1x20 -0+14 94 67 15.0 4.0 bilb A caloric restr.-30% pair-fed Zucker other+ Koch 08->18480976 2.54 61 both no Rz" dmh 4x15 -2+9 206 81 17 5.0 2.1 1.7 A caloric restr.-30% pair-fed Zucker other+ Koch 08->18480976 2.54 61 3.4 1.24 both no Rz" dmh 4x15 -2+9 206 81 17 5.0 2.1 1.7 res A selenium in milk prot. 1ppm other+ Hu McIntosh 08->18559541 2.19 54 2.3 both blind Mc' aom 4x15 -2+10 12 5 3.5 1.5 sel A EGCG 0.1% drink.water /mice phyto+ Shimizu 08->19138973 1.48 33 2.5 post no Ml' aom 4x15 +1+8 83 56 33.5 13.5 egcg A EGCG 0.1% drnk.w /mice *BCAC* phyto+ Shimizu 08->19138973 2.32 57 post no Ml' aom 4x15 +1+8 13 6 egcg A thiazolidinedione PPARgam 10mg/kg Ppar+ Su Nesela 08->18546290 4.00 75 both ,o Mc" aom 4x10 -1+15 8 2 thia A nobiletin 0.05% //PhIP phyto+ Tang Ogawa 11->21298591 1.57 36 1.9 post no Rf' phip 20x100 50 14 9 4.6 2.4 nob A caraway seed ess.oil 0.1% ! phyto+ Dadkhah 11->21108126 5.40 81 0.7 3.6 both no Rw' dmh 5x20 -0+16 6.7 1.2 1.19 1.76 car A apple 5g/d phyto+ Poulsen 11->21432724 1.77 43 2.0 both no Rf' dmh 4x20 po -3+11 53 30 8.1 4.0 apl 10g/d no protect A Lychnophora eric.extr.0.4%/water phyto+ Fernandes 11->21526453 2.21 55 both no Rw' dmh 02x40 -2+4 18 8 Lyc A aspirin + folic + calcium High combi+ Chaudary 11->21914855 11.3 91 both blind Rs' aom 2x15 +1+15 30 3 400+32+650 mg/kg A aspirin + folic + calcium Low combi+ Chaudary 11->21914855 1.38 27 post blind Rs' aom 2x15 +1+15 44 32 40+3.2+65 mg/kg A (aspirin+folic) nanopart.+ calcium combi+ Chaudary 11->21914855 1.97 49 post blind Rs' aom 2x15 +1+15 19 10 40+3.2+65 mg/kg A (aspirin+folic+calcium) nanopart. combi+ Chaudary 11->21914855 2.15 53 post blind Rs' aom 2x15 +1+15 44 20 40+3.2+65 mg/kg A naproxen 400ppm NSAI+ Steele 09->19892664 2.34 57 3.6 post no Rf' aom 2x15 +1+8 145 62 36 10 nap A cocoa 12% phyto Rodriguez 11->21953728 2.09 52 2.6 both blind Rw' aom 2x20 -2+5 19 9 3.9 1.5 cho